Genes News and Research

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AMT, NIH enter exclusive license agreement for use of AAV5-based gene therapy vectors

Amsterdam Molecular Therapeutics, a leader in the field of human gene therapy, today announced that it has entered into an exclusive license agreement with the US National Institutes of Health (NIH) for use of adeno-associated virus serotype 5 (AAV5)-based gene therapy vectors for liver and brain indications.

6 Sep 2011

Study: No big shift toward higher fatal heart attack rates after menopause in women

Contradicting the long-held medical belief that the risk of cardiovascular death for women spikes sharply after menopause, new research from Johns Hopkins suggests instead that heart disease mortality rates in women progress at a constant rate as they age.

6 Sep 2011

Researchers discover novel way to increase amounts of antibiotics

A novel way of increasing the amounts of antibiotics produced by bacteria has been discovered that could markedly improve the yields of these important compounds in commercial production. It could also be valuable in helping to discover new compounds. With the ever-growing threat from antibiotic resistance, these tools will be very useful in ensuring that we have enough of these useful compounds in the future.

5 Sep 2011

Cancer cells with specific genetic defect extra susceptible to therapy that damages DNA

Using a strategy based on treating cancer cells that carry a specific genetic signature - hyper-expression of the protein Myc - with therapy that affects the stability of the cell's DNA, more effective results can be achieved.

5 Sep 2011

Researchers discover gene mutation linked with lymphoedema, leukaemia

Researchers have discovered a gene that when mutated can cause lymphoedema (swollen limbs due to a failure of the lymph system), immune abnormalities, deafness and leukaemia.

5 Sep 2011

Scientists purify PARP protein that shows promise against breast, ovarian cancers

CANCER RESEARCH UK scientists have succeeded in purifying a protein found in bacteria that could reveal new drug targets for inherited breast and ovarian cancers - and other cancers linked to DNA repair faults.

5 Sep 2011

IKEPLUS immunization completely eliminates TB bacteria from infected tissues

A potential vaccine against tuberculosis has been found to completely eliminate tuberculosis bacteria from infected tissues in some mice. The vaccine was created with a strain of bacteria that, due to the absence of a few genes, are unable to avoid its host's first-line immune response.

5 Sep 2011

Researchers discover group of mutations involved in T-cell acute lymphoblastic leukemia

An international team of researchers has found a group of mutations involved in T-cell acute lymphoblastic leukemia (T-ALL), and showed that a group of certain drugs, already in clinical use to treat other diseases, can eliminate the cells carrying these mutations.

5 Sep 2011

Researchers discover new genetic defect that predisposes people to leukemia, myelodysplasia

A new genetic defect that predisposes people to acute myeloid leukemia and myelodysplasia has been discovered. The mutations were found in the GATA2 gene. Among its several regulatory roles, the gene acts as a master control during the transition of primitive blood-forming cells into white blood cells.

5 Sep 2011

Einstein researchers develop tuberculosis vaccine candidate

Researchers at Albert Einstein College of Medicine of Yeshiva University report in the September 4 online edition of Nature Medicine that they have developed a tuberculosis (TB) vaccine candidate that proved both potent and safe in animal studies.

5 Sep 2011

Study describes new class of anti-diabetic compound that targets unique molecular switch

In a joint study, scientists from The Scripps Research Institute and Harvard University's Dana-Farber Cancer Institute have established a new class of anti-diabetic compound that targets a unique molecular switch.

5 Sep 2011

Scientists sequence ten variants of E. coli O104:H4 outbreak strain across the world

Ten variants of the deadly Escherichia coli strain that hit Germany in May 2011 have been sequenced across the world. The unprecedented level of collaboration across the scientific community should give insight into how the outbreak arose, says a scientist at the Society for General Microbiology's Autumn Conference 2011.

5 Sep 2011

Scientists discover highly conserved mechanism governing brain development

If you think today's political rhetoric is overheated, imagine what goes on inside a vertebrate embryo. There, two armies whose agendas are poles apart, engage in a battle with consequences much more dire than whether the economy will recover---- they are battling for whether you (or frogs or chickens) will have a forebrain.

3 Sep 2011

Scientists uncover one of the benefits of non-monogamous relationships

It's all about the grandkids! That's what a team led by an Indiana University biologist has learned about promiscuous female birds and why they mate outside their social pair.

3 Sep 2011

Study: Growth hormone helps regenerate damaged hair cells in zebrafish ear

Loud noise, especially repeated loud noise, is known to cause irreversible damage to the hair cells inside the cochlea and eventually lead to deafness. In mammals this is irreversible, however both birds and fish are able to re-grow the damaged hair cells and restore hearing.

3 Sep 2011

Discovery in rare disease may shed light on common causes of blindness

In a rare eye disease, the retina degenerates because light-receiving cells fail to regenerate, research led by a student at Case Western Reserve University School of Medicine shows.

2 Sep 2011

Chromatin might have another life as direct signaling molecule

Chromatin - the intertwined histone proteins and DNA that make up chromosomes - constantly receives messages that pour in from a cell's intricate signaling networks: Turn that gene on. Stifle that one. But chromatin also talks back, scientists at The University of Texas MD Anderson Cancer Center report today in the journal Cell, issuing orders affecting a protein that has nothing to do with chromatin's central role in gene transcription - the first step in protein formation.

2 Sep 2011

Genes News and Research

AMT, NIH enter exclusive license agreement for use of AAV5-based gene therapy vectors

Study: No big shift toward higher fatal heart attack rates after menopause in women

Researchers discover novel way to increase amounts of antibiotics

Cancer cells with specific genetic defect extra susceptible to therapy that damages DNA

Researchers discover gene mutation linked with lymphoedema, leukaemia

Scientists purify PARP protein that shows promise against breast, ovarian cancers

IKEPLUS immunization completely eliminates TB bacteria from infected tissues

Researchers discover group of mutations involved in T-cell acute lymphoblastic leukemia

Researchers discover new genetic defect that predisposes people to leukemia, myelodysplasia

Einstein researchers develop tuberculosis vaccine candidate

Study describes new class of anti-diabetic compound that targets unique molecular switch

Scientists sequence ten variants of E. coli O104:H4 outbreak strain across the world

Scientists discover highly conserved mechanism governing brain development

Scientists uncover one of the benefits of non-monogamous relationships

Study: Growth hormone helps regenerate damaged hair cells in zebrafish ear

Discovery in rare disease may shed light on common causes of blindness

Chromatin might have another life as direct signaling molecule

New genetic screening program for families at high risk of colorectal cancer

UVA researchers develop 3-D model to visualize early growth of human breast tissue

Walnut-containing diet could reduce risk of breast cancer

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