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Review highlights the interplay of TGF-β and HIPPO pathways in liver regeneration and disease

The liver's ability to communicate with other organs is crucial for maintaining homeostasis, particularly through signaling pathways.

30 Jul 2024

Deciphering miRNA-mediated regulation of liver regeneration: New insights

The liver, a vital organ involved in numerous essential physiological processes such as bile production, plasma protein synthesis, nutrient absorption, detoxification, vitamin storage, macronutrient metabolism, and immune support, has a remarkable regenerative capacity.

29 Jul 2024

Study identifies non-statin cholesterol drugs with potential to lower liver cancer risk

Past studies have suggested that taking cholesterol-lowering statin drugs may lower individuals' risk of developing liver cancer.

29 Jul 2024

Innovative dual-drug strategy for colorectal cancer treatment

A combination of two drugs was capable of suppressing tumors in a non-conventional manner. Instead of inhibiting tumor cell division, as the most widely used medications do, the strategy consisted of hyperactivating oncogenic signaling by these cells to the point where they became stressed.

27 Jul 2024

Archaea: Unseen players in human microbiome and infectious diseases

Archaea, key players in the human microbiome, are linked to various diseases but their pathogenic potential remains speculative. This study highlights their role in conditions like periodontitis and gastrointestinal infections.

16 Jul 2024

Existing drug shows promise for treating common liver disease

The University of Barcelona has led a study that suggests using the drug known as pemafibrate to treat liver disease associated with metabolic disorders, the most common liver pathology in the world, which affects one in four people. The drug has long been marketed in Japan for another use: improving blood lipid levels in patients with hyperlipidaemia, a common condition in diabetics. Now, however, it could help address this serious liver disease, which still has no specific treatment.

11 Jul 2024

Repurposing pemafibrate to treat liver disease associated with metabolic disorders

10 Jul 2024

Innovative study on gut bacteria and T cells wins NOSTER & Science Microbiome Prize

In the gut, dozens of strains of bacteria exert different effects on the immune system that in turn impact our health – fending off pathogens, helping digest food and maybe even influencing behavior. But pinpointing which bacteria exert which effects has been challenging.

4 Jul 2024

Study suggests gastric bypass can reduce cardiovascular disease risk, irrespective of weight loss

Researchers investigated whether Roux-en-Y gastric bypass reduces cardiovascular risk factors independent of calorie restriction and weight loss.

4 Jul 2024

Decoding the significance of subnormal liver enzyme activity

Liver diseases are commonly diagnosed using serum enzyme assays, particularly for aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (ALP), gamma-glutamyl transpeptidase (GGT), and 5'-nucleotidase (5'-NT).

3 Jul 2024

New study reveals ketogenic diet's role in combating obesity

Researchers showed that ketogenic diet (KD)-induced bile acids (BAs) are protective against obesity.

1 Jul 2024

Higher intake of ultra-processed foods found to increase cancer mortality risk

The association between ultra-processed food (UPF) consumption and gastrointestinal (GI) cancers.

26 Jun 2024

Using real-world data to assess medication-related liver toxicity

The current method for assessing medication-related liver injury is not providing an accurate picture of some medications' toxicity - or lack thereof - to the liver, according to a new study led by researchers from the Perelman School of Medicine at the University of Pennsylvania.

25 Jun 2024

Targeting the gut microbiome: A new approach to treating diabetes

Researchers review the role of gut microbiota in the pathogenesis and management of diabetes mellitus.

24 Jun 2024

Challenges in treatment of cholangiocarcinoma in patients with primary sclerosing cholangitis

Primary sclerosing cholangitis (PSC) is a rare progressive liver disease that damages bile ducts and significantly increases the risk of bile duct cancer, particularly a type called cholangiocarcinoma (CCA).

20 Jun 2024

Bile acids: Balancing digestive health and liver toxicity

Bile acids are essential molecules the liver produces that play a critical role in digestion. They help us absorb fat-soluble vitamins and cholesterol from our food.

6 Jun 2024

Elevated TMAO levels linked to higher diabetes risk, study finds

A recent Nutrients study links elevated trimethylamine N-oxide (TMAO) levels with an increased risk of type 2 diabetes, highlighting the role of diet in diabetes prevention.

4 Jun 2024

Do ultra-processed foods alter the gut microbiome?

A review in the journal Nutrients highlights the negative impact of ultra-processed foods on the gut microbiome and the challenges in using the NOVA food classification system in research.

3 Jun 2024

Taurine supplementation shows promise in reducing metabolic syndrome risk factors, study finds

A study in Nutrition & Diabetes meta-analyzed randomized clinical trials and found that taurine supplementation significantly reduces key risk factors for metabolic syndrome, such as high blood pressure, fasting blood glucose, and triglycerides, with no notable adverse effects.

20 May 2024

Metabolomics study finds biomarkers predicting autism in newborns

A study in Communications Biology utilized metabolomics in newborns to identify markers that might predict autism spectrum disorder (ASD), finding distinct metabolic profiles in children with ASD compared to typically developing children.

14 May 2024