OCT News and Research

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Breakthrough study maps impact of thousands of variants in heart disease gene

An international research consortium co-led by scientists from Vanderbilt University Medical Center, the University of Toronto and University of Pittsburgh has mapped the functional impact of more than 17,000 variants in a major gene associated with the development of premature atherosclerotic heart disease.

31 Oct 2025

Mathematical models explain food movement and churning in the digestive tract

Synchronization abounds in nature: from the flashing lights of fireflies to the movement of fish wriggling through the ocean, biological systems are often in rhythmic movement with each other.

31 Oct 2025

How nerve cells in the gut adapt to microbial and immune challenges

Ramnik Xavier, MD, PhD, of the Department of Molecular Biology at Massachusetts General Hospital, is the senior author of a paper published in Science, "Regional encoding of enteric nervous system responses to microbiota and type 2 inflammation."

31 Oct 2025

Exploring the link between underweight status and gut microbiota composition in Japanese women

Low body weight in young women has been linked to a range of health concerns, including disrupted menstrual cycles, infertility, weakened immune function, and a long-term decline in bone density.

31 Oct 2025

Studies identify complementary approaches to overcome drug resistance in KRAS G12C–mutant lung cancer

Two companion studies published in Cancer Research from scientists at Moffitt Cancer Center identify distinct but complementary approaches to overcoming drug resistance in KRAS G12C–mutant non-small cell lung cancer.

31 Oct 2025

Evidence of previously unrecognized hub in the brain's lymphatic drainage system revealed

How does the brain take out its trash? That is the job of the brain's lymphatic drainage system, and efforts to understand how it works have pushed the boundaries of brain-imaging technologies.

31 Oct 2025

Study reveals how TDP-43 causes neuronal overactivity in ALS and FTD

A new Northwestern University study using patient nervous tissue and lab-grown human neurons has uncovered how a key disease protein, TDP-43, drives overactive nerve cells in the neurodegenerative diseases amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

31 Oct 2025

Global study suggests potential for universal vaccine against Haemophilus influenzae

A vaccine that tackles the bacteria that cause up to 200 million childhood infections every year could be possible, experts say.

31 Oct 2025

Novel nanoparticles can deliver an immune-stimulating molecule directly to ovarian tumors

Cancer immunotherapy, which uses drugs that stimulate the body's immune cells to attack tumors, is a promising approach to treating many types of cancer. However, it doesn't work well for some tumors, including ovarian cancer.

31 Oct 2025

COVID-19 in pregnancy may raise autism and neurodevelopmental disorder risk

Children born to mothers who contracted COVID-19 during pregnancy face a 29% higher likelihood of developmental disorders by age three, including speech, motor, and autism-spectrum delays. The risk was greatest for male offspring and infections occurring in the third trimester.

30 Oct 2025

Researchers uncover mechanism by which BRCA2-deficient tumors develop chemoresistance

One of the biggest challenges in cancer treatment is chemoresistance: tumors that initially respond well to chemotherapy become resistant over time. When that happens, treatment options are often limited.

30 Oct 2025

Study uncovers neural mechanisms behind memory stabilization

Newly decoded brain circuits make memories more stable as part of learning, according to a new study led by NYU Langone Health researchers.

30 Oct 2025

Study finds more commonalities between CTE and Alzheimer's disease at the genetic level

Chronic traumatic encephalopathy (CTE) – most often found in athletes playing contact sports – is known to share similarities with Alzheimer's disease (AD), namely the buildup of a protein called tau in the brain.

30 Oct 2025

First-of-its-kind resource created to identify people with genetic risk for elevated 'bad' cholesterol

An international team led by a University of Pittsburgh School of Medicine scientist has created a first-of-its-kind resource to identify those with a genetic risk for elevated 'bad' cholesterol -- a major contributor to heart disease.

30 Oct 2025

19 NCAA women's college basketball coaches join hands to support women’s heart health

Both on the court and off, cardiovascular disease is the leading killer of women in the United States, taking the lives of more than 440,000 women each year, according to the American Heart Association, a relentless force changing the future of health for everyone everywhere.

30 Oct 2025

Oligodendrocyte progenitor cells promote blood vessel growth after stroke

Stroke is a leading cause of death and disability, affecting 1 in 4 people during their lifetime. Stroke happens when blood vessels in the brain get clogged or damaged, impairing blood flow and oxygen supply to the brain, which leads to death of neurons and other brain cells.

30 Oct 2025

New method yields up to twice as many therapeutic myogenic cells as previous protocols

If cancer is a disease of overabundance, where cells divide without restraint and tumors grow despite the body's best interests, then degenerative diseases are disorders of deprivation.

30 Oct 2025

Minimal fibers enable communication between brain hemispheres

Just a few fibers are enough for the two hemispheres of the brain to communicate with each other. This was shown by a new international study led by Professor Dr Michael Miller (University of California, Santa Barbara) and Professor Dr Lukas J. Volz (Department of Neurology at University Hospital Cologne and the University of Cologne's Faculty of Medicine) in close collaboration with Professor Dr Christian Bien's team at the Bethel Epilepsy Centre (University Hospital OWL at Bielefeld University).

30 Oct 2025

Unusual presentation of vulvar mucinous cyst with multiple bartholin cysts in a reproductive-age woman

A new case report was published in Volume 12 of Oncoscience on October 9, 2025, titled "Vulvar mucinous cyst mimicking common lesions with concurrent multiple bartholin cysts in a reproductive-age woman: A rare case report and review of literature."

30 Oct 2025

TROP2 identified as a promising therapeutic target for renal medullary carcinoma

Researchers at The University of Texas MD Anderson Cancer Center, in collaboration with BostonGene, conducted the largest and most comprehensive molecular analysis of renal medullary carcinoma (RMC), a rare and aggressive form of kidney cancer, leading to the identification of TROP2 as a promising therapeutic target.

30 Oct 2025

OCT News and Research

Breakthrough study maps impact of thousands of variants in heart disease gene

Mathematical models explain food movement and churning in the digestive tract

How nerve cells in the gut adapt to microbial and immune challenges

Exploring the link between underweight status and gut microbiota composition in Japanese women

Studies identify complementary approaches to overcome drug resistance in KRAS G12C–mutant lung cancer

Evidence of previously unrecognized hub in the brain's lymphatic drainage system revealed

Study reveals how TDP-43 causes neuronal overactivity in ALS and FTD

Global study suggests potential for universal vaccine against Haemophilus influenzae

Novel nanoparticles can deliver an immune-stimulating molecule directly to ovarian tumors

COVID-19 in pregnancy may raise autism and neurodevelopmental disorder risk

Researchers uncover mechanism by which BRCA2-deficient tumors develop chemoresistance

Study uncovers neural mechanisms behind memory stabilization

Study finds more commonalities between CTE and Alzheimer's disease at the genetic level

First-of-its-kind resource created to identify people with genetic risk for elevated 'bad' cholesterol

19 NCAA women's college basketball coaches join hands to support women’s heart health

Oligodendrocyte progenitor cells promote blood vessel growth after stroke

New method yields up to twice as many therapeutic myogenic cells as previous protocols

Minimal fibers enable communication between brain hemispheres

Unusual presentation of vulvar mucinous cyst with multiple bartholin cysts in a reproductive-age woman

TROP2 identified as a promising therapeutic target for renal medullary carcinoma

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