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Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

A new study aimed to clarify whether extensive RBD mutations could affect the magnitude and immunodominance hierarchy of the host antibody response.

18 Feb 2022

COVID-19 vaccine-induced immunity in heart and kidney solid organ transplant recipients

The present study entailed assessments of both infected and uninfected SOTRs against the D614G-CoV2 baseline virus and eight other variants.

17 Feb 2022

Memory B cell repertoire in a longitudinal cohort of individuals receiving 3 COVID-19 mRNA vaccine doses

Researchers examined the memory B cell repertoire of individuals immunized with three doses of mRNA-based COVID-19 vaccine.

17 Feb 2022

Study analyzes antigenic properties of SARS-CoV-2 Omicron sublineages

A new study elucidated the antigenic properties of the sublineages of the severe acute respiratory syndrome coronavirus-2 Omicron variant.

14 Feb 2022

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

In a study posted to the bioRxiv* preprint server, a team of researchers from the United States evaluated the protective effect of the preclinical version of the current Moderna Omicron-targeted mRNA-1273.529 vaccine against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) B.1.1.529 Omicron infection in mice.

14 Feb 2022

Study provides evidence for spike protein-independent attenuation of SARS-CoV-2 Omicron variant

A new study provided the structural basis for a robust interaction between the receptor-binding domain of the SARS-CoV-2 Omicron spike protein and mouse ACE2.

13 Feb 2022

Rapid generation and evaluation of an mRNA vaccine candidate specific to Omicron

A recent study demonstrated the development of a potential SARS-CoV-2 Omicron variant-specific mRNA vaccine candidate.

10 Feb 2022

Protective efficacy of BNT162b2 and Ad26.COV2.S against SARS-CoV-2 Omicron challenge in nonhuman primates

The study highlights the significance of mix-and-match vaccine regimens to diversify the immune responses against highly mutated variants of SARS-CoV-2 such as Omicron.

10 Feb 2022

Study compares the neutralizing potential of antibodies against two Omicron variants

A new study investigates if the two SARS-CoV-2 Omicron variants BA.1 and BA.2 are comparable with respect to their ability to evade the host immunity induced by vaccination or prior infection.

9 Feb 2022

Induction and stability of vaccine-specific antibodies in multiple sclerosis patients on different disease-modifying therapies

Researchers have investigated the lack of response to treatment in certain multiple sclerosis patients.

9 Feb 2022

Memory B cells induced by mRNA vaccine may help generate antibodies against Omicron

In a recent research article published in the journal of Science Immunology, a team of researchers from Japan performed longitudinal analysis on the cellular composition of receptor-binding domain (RBD) memory B cell subsets and its antibody binding and neutralizing activity against the Beta, Delta, and Omicron variants following the second dose of a messenger ribonucleic acid (mRNA) vaccine.

8 Feb 2022

Novel, rapid and efficient assay for SARS-CoV-2 neutralizing antibodies

Researchers validate a quick, highly efficient, and automated assay to detect neutralizing antibodies against SARS-CoV-2.

7 Feb 2022

Booster dose of Pfizer-BioNTech COVID vaccine protects elderly against Omicron

Researchers discuss the impact of mRNA booster immunization on the neutralizing activity against the SARS-CoV-2 Omicron variant in the elderly.

6 Feb 2022

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Researchers evaluate how the D614G and P681H mutations alter the attributes of SARS-CoV-2 VOCs.

3 Feb 2022

Nanoparticle vaccine effective against eight SARS-CoV-2 variants in non-human primates

Researchers demonstrate that SARS-CoV-2 RBD-based nanoparticle vaccine induces neutralizing antibodies against SARS-CoV-2 variants.

2 Feb 2022

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

A large multinational group of researchers has shown how the Omicron variant of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has gained exceptional immune evasion properties but also a much lower propensity to enter cells such as those in lung alveoli, resulting in its reduced pathogenicity. Their paper is currently released as an unedited version of the manuscript prior to publication in the journal Nature.

1 Feb 2022

Pseudovirus News and Research

Study finds antigenic profile of Omicron RBD is distinct from the prior SARS-CoV-2 variants of concern

COVID-19 vaccine-induced immunity in heart and kidney solid organ transplant recipients

Memory B cell repertoire in a longitudinal cohort of individuals receiving 3 COVID-19 mRNA vaccine doses

Study analyzes antigenic properties of SARS-CoV-2 Omicron sublineages

mRNA-1273 and mRNA-1273.529 Omicron-specific boosters highly effective in mouse model

Study provides evidence for spike protein-independent attenuation of SARS-CoV-2 Omicron variant

Rapid generation and evaluation of an mRNA vaccine candidate specific to Omicron

Protective efficacy of BNT162b2 and Ad26.COV2.S against SARS-CoV-2 Omicron challenge in nonhuman primates

Study compares the neutralizing potential of antibodies against two Omicron variants

Induction and stability of vaccine-specific antibodies in multiple sclerosis patients on different disease-modifying therapies

Memory B cells induced by mRNA vaccine may help generate antibodies against Omicron

Novel, rapid and efficient assay for SARS-CoV-2 neutralizing antibodies

Booster dose of Pfizer-BioNTech COVID vaccine protects elderly against Omicron

Evaluating effects of D614G and P681R/H mutations on SARS-CoV-2 VOCs

Nanoparticle vaccine effective against eight SARS-CoV-2 variants in non-human primates

Study confirms SARS-CoV-2 Omicron variant has a decreased ability to enter lung cells

Exploring beta-coronavirus neutralization by vaccine-induced murine antibody WS6

Preliminary study assesses durability of NAb titers against Omicron after mRNA-1273 booster

Children and adolescents respond as well or better than adults to mRNA-1273 COVID vaccination

Scientists evaluate zoonotic potential of NeoCoV, a coronavirus related to MERS-CoV

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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