Microscopy News and Research

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Study links SARS-CoV-2 seasonality to increased spread at lower temperatures

In a recent paper available on the bioRxiv preprint server, US researchers show that individual particles of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) undergo structural destabilization at relatively mild but elevated temperatures – strengthening the case for coronavirus disease (COVID-19) resurgence in the winter.

15 Oct 2020

ACE2 binding causes dissociation of trimeric SARS-CoV-2 spike, may be used to inhibit further infection

A recent study published on the preprint server bioRxiv in October 2020 shows that severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) binding to the human host receptor could cause the typical trimeric spike protein to come apart, forming a stable monomer instead with the receptor.

14 Oct 2020

Scientists produce biodegradable nanocoating with antimicrobial and anti-reflective properties

Scientists from Russia and Switzerland have probed into nanostructures covering the corneas of the eyes of small fruit flies. Investigating them the team learned how to produce the safe biodegradable nanocoating with antimicrobial, anti-reflective, and self-cleaning properties in a cost-effective and eco-friendly way.

14 Oct 2020

3D structural model of BAF complex modifies DNA architecture, provides clues on cancer

Scientists have created an unprecedented 3-dimensional structural model of a key molecular "machine" known as the BAF complex, which modifies DNA architecture and is frequently mutated in cancer and some other diseases.

14 Oct 2020

Researchers discuss methods to produce core-sheath polymer fibers

Wound dressing, tissue scaffolding, controlled and sustained drug delivery, and cardiac patching are all biomedical processes requiring a material that combines strength with functionality.

14 Oct 2020

D614G mutation in SARS-CoV-2 increases viral fitness and infectivity

Researchers from the Duke Human Vaccine Institute and Duke University, Durham NC, USA, recently analyzed the D614G mutation in SARS-CoV-2 in the context of a soluble S ectodomain construct. Their study has been published in the preprint server bioRxiv.

14 Oct 2020

Scientists examine a novel approach to analyzing dendritic spine shapes

Dendritic spines are small protrusions from a neuron's dendrite membrane, where contact with neighboring axons is formed to receive synaptic input.

13 Oct 2020

NYU scientists develop a method using holographic imaging to detect viruses, antibodies

A team of New York University scientists has developed a method using holographic imaging to detect both viruses and antibodies. The breakthrough has the potential to aid in medical diagnoses and, specifically, those related to the COVID-19 pandemic.

13 Oct 2020

Penn State researcher leads $3.8 million project to create an atlas of developing mice brains

A grant from the National Institutes of Health will allow a Penn State College of Medicine researcher to lead a three-year, multi-institution project to create an atlas of developing mice brains.

13 Oct 2020

Axol Bioscience introduces multi-electrode array screening services for human iPSC-derived cells

Axol Bioscience today announced the expansion of its services, with the introduction of array screening for human induced pluripotent stem cells.

From Axol Bioscience Ltd 13 Oct 2020

Genoscience Pharma's GNS561 shows potential against SARS-CoV-2 in vitro

A new study published on the preprint server bioRxiv in October 2020 shows that a combination of a new compound GNS561 and remdesivir act synergistically against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This suggests that autophagy inhibitors could be an alternative strategy for SARS-CoV-2 infection.

12 Oct 2020

Study shows unique cardioprotective properties of an old drug

A drug costing less than 2 euros per dose could reduce the long term consequences of a heart attack, benefitting millions of patients. Metoprolol, a member of the beta-blocker class of drugs that has been in use for more than 40 years, has been found to have unique cardioprotective properties.

9 Oct 2020

Researchers receive €2.35 million to examine disease pathways of viruses

Two University College Dublin (UCD) researchers and SiriusXT, a UCD spin-out company, have been awarded a total of €2.35 million in funding for a disruptive photonics technology project, through Horizon 2020, the EU's research and innovation programme, to examine the disease pathways of viruses.

9 Oct 2020

New drug delivery systems can improve treatment for diseases that affect connective tissues

University of Delaware Professor Kristi Kiick is leading collaborative research to create new drug delivery systems with the potential to improve treatment for diseases that affect connective tissues, such as osteoarthritis or rheumatoid arthritis, which is an autoimmune disease.

9 Oct 2020

Scientists recreate initial steps of HIV infection in a test tube

Accomplishing a feat that had been a pipe dream for decades, scientists have recreated in a test tube the first steps of infection by HIV (human immunodeficiency virus), the virus that causes AIDS (acquired immunodeficiency syndrome).

9 Oct 2020

Researchers study a new method for creating semisolid colloidal systems

Researchers in the Institute of Industrial Science at The University of Tokyo studied a new method for creating semisolid colloidal systems with less internal mechanical stress by delaying network formation. This work may help scientists better understand biological processes involving cytoplasm.

9 Oct 2020

Scientists refine SARS-CoV-2 protein structures

An international team of scientists has developed computational models to re-analyze and validate experimentally-derived publicly available macromolecular structures of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

8 Oct 2020

Intracellular ATP levels in the cortical neurons vary with sleep–wake states, animal study shows

It is assumed that the brain has homeostatic mechanisms to prevent the depletion of cellular energy, required for all cellular activities.

7 Oct 2020

SARS-CoV-2 infection analysis could help fight against COVID-19

Researchers in the United States has provided a detailed catalog of the interactions that occur between host cell proteins and RNA and the RNA of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) during the course of infection.

7 Oct 2020

Using virus-like particles to study SARS-CoV-2 assembly, budding, and entry

In a recent preprint paper published on the bioRxiv server, researchers from the Purdue Institute of Inflammation, Immunology, and Infectious Disease, Purdue University, West Lafayette, IN, discuss their efforts to assess the 4 SARS-CoV-2 structural proteins for their ability to produce VLPs from human cells to create a competent system for BSL-2 studies of SARS-CoV-2.

6 Oct 2020

Microscopy News and Research

Study links SARS-CoV-2 seasonality to increased spread at lower temperatures

ACE2 binding causes dissociation of trimeric SARS-CoV-2 spike, may be used to inhibit further infection

Scientists produce biodegradable nanocoating with antimicrobial and anti-reflective properties

3D structural model of BAF complex modifies DNA architecture, provides clues on cancer

Researchers discuss methods to produce core-sheath polymer fibers

D614G mutation in SARS-CoV-2 increases viral fitness and infectivity

Scientists examine a novel approach to analyzing dendritic spine shapes

NYU scientists develop a method using holographic imaging to detect viruses, antibodies

Penn State researcher leads $3.8 million project to create an atlas of developing mice brains

Axol Bioscience introduces multi-electrode array screening services for human iPSC-derived cells

Genoscience Pharma's GNS561 shows potential against SARS-CoV-2 in vitro

Study shows unique cardioprotective properties of an old drug

Researchers receive €2.35 million to examine disease pathways of viruses

New drug delivery systems can improve treatment for diseases that affect connective tissues

Scientists recreate initial steps of HIV infection in a test tube

Researchers study a new method for creating semisolid colloidal systems

Scientists refine SARS-CoV-2 protein structures

Intracellular ATP levels in the cortical neurons vary with sleep–wake states, animal study shows

SARS-CoV-2 infection analysis could help fight against COVID-19

Using virus-like particles to study SARS-CoV-2 assembly, budding, and entry

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