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Research shows how stress changes structure of the brain

Research led by Si-Qiong June Liu, MD, Ph.D., Professor of Cell Biology and Anatomy at LSU Health New Orleans School of Medicine, has shown how stress changes the structure of the brain and reveals a potential therapeutic target to the prevent or reverse it

14 Apr 2020

Toxic cell atlas can guide discovery of new drugs for neurodegeneration

A common thread in many inflammatory and neurodegenerative diseases, including multiple sclerosis (MS), is damage caused by oxidative stress. Oxidative stress occurs when cells produce toxic substances known as reactive oxygen species, which are damaging nerve cells and other cells in the body.

13 Apr 2020

Molecular pathway responsible for TNBC's progression and spread identified

Immunotherapies have revolutionized treatment for people with a variety of cancers. But when given to those with triple-negative breast cancer, a particularly aggressive form of the disease, less than 20% respond.

13 Apr 2020

Inhibition of sphingolipid metabolism and neurodegenerative diseases

Disrupting production of sphingolipids in neurons improved neurodegeneration symptoms and increased survival in a mouse model.

13 Apr 2020

New Vietnamese enterovirus C4 strains possibly more virulent than B5 strains

A new study published in January 2020 in the journal Scientific Reports reports the presence of a new lineage of enterovirus responsible for the hand-foot-and-mouth disease (HFMD). They think this could be more virulent than the earlier B5 subtype.

12 Apr 2020

PIV5-based MERS vaccine shows promise for COVID-19

The coronavirus disease (COVID-19) has spread to 184 countries and territories. Currently, there is no vaccine available for COVID-19 disease, or SARS-CoV-2 infection. However, scientists around the world are racing to find ways to block the virus.

8 Apr 2020

Common protein in skin can directly activate itch-associated neurons

A commonly expressed protein in skin - periostin - can directly activate itch-associated neurons in the skin, according to new research from North Carolina State University.

7 Apr 2020

Compound in fruit peels can reduce and reverse neuronal damage in multiple sclerosis

Multiple sclerosis, characterized by increasing muscle weakness and paralysis, has a number of treatments that help stall progression of the disease when used early on in the disease.

6 Apr 2020

Research suggests an avenue to treat, prevent genetic disorders in the womb

New research led by hearing scientists at Oregon Health & Science University suggests an avenue to treat and prevent intractable genetic disorders before birth.

6 Apr 2020

Novel immunotherapy eradicates solid tumors in mice without adverse side effects

Scientists have developed a new immunotherapy that eradicates solid tumors in mice without adverse side effects, according to a new study published today in eLife.

31 Mar 2020

UDCA treatment affects C. diff life cycle, reduces inflammatory response in mice

Researchers from North Carolina State University have found that a commonly used drug made from secondary bile acids can affect the life cycle of Clostridioides difficile (C. diff) in vitro and reduce the inflammatory response to C. diff in mice.

30 Mar 2020

Paternal alcohol consumption before conception could affect child development

Scientists at the University of California, Riverside, have explored the relationship between parental alcohol consumption -- before conception in the case of fathers and during pregnancy in the case of mothers -- and offspring development.

30 Mar 2020

New drug shows promise to reverse treatment resistance in advanced multiple myeloma

Researchers at the VU University Medical Center in the Netherlands have tested a new drug in patient samples and mice with multiple myeloma and discovered that it was effective even in advanced disease - a point when many patients currently run out of options.

27 Mar 2020

Study contradicts theory that daily aspirin prevents dementia symptoms

Scientists have disproven the theory that taking a low dose of daily aspirin reduces cognitive symptoms of dementia.

25 Mar 2020

Cancer could potentially be treated with new immunotherapy approach, say researchers

Researchers have made a discovery about EGR4 that could instigate a new immunotherapy approach to treating cancer.

25 Mar 2020

Study identifies brake on immune activity raising new possibilities for anticancer therapy

The immune system is like a carefully regulated machine, complete with its own built-in "brakes" that prevent it from overreacting and causing excess inflammation in otherwise healthy tissues.

25 Mar 2020

YAP signal pathway plays a vital role in the onset of head-and-neck cancer

Joint research between Kobe University and National Hospital Organization Kyushu Cancer Center has revealed that mice with mutations in the YAP signal pathway develop head-and-neck cancer over an extremely short period of time (world's fastest cancer onset mouse model), indicating that this pathway plays a crucial role in the onset of these cancers.

25 Mar 2020