Signaling Pathway News and Research

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Immune cells play surprising role in cystic fibrosis lung damage

Immune cells once thought to be innocent bystanders in cystic fibrosis may hold the key to stopping patients' fatal lung disease.

16 Mar 2009

Potential pathway for drug intervention

A newly identified molecular pathway that directs stem cells to produce glial cells yields insights into the neurobiology of Down's syndrome and a number of central nervous system disorders characterized by too many glial cells, according to a recent study by researchers at the Salk Institute for Biological Studies.

15 Mar 2009

New investigational therapy for the treatment of bladder cancer

A team of researchers, led by Columbia University Medical Center faculty, has identified a new investigational therapy for the treatment of bladder cancer.

12 Mar 2009

Immune reaction to metals in joint replacement devices leads to early failure

Researchers at Rush University Medical Center have identified a key immunological defense reaction to the metals in joint replacement devices, leading to loosening of the components and early failure.

4 Mar 2009

Take 2: What protein and where it is located are important for drug design

Drugs that target a single signaling pathway that drives tumor development and/or progression have been developed successfully to treat a few forms of cancer.

23 Feb 2009

Tumor suppressor may weaken fibrotic disease

New research reveals a critical cellular signaling pathway that is responsible for generating excess connective tissue in multiple organs, similar to what is seen in human patients with scleroderma.

18 Feb 2009

Targeting the protein AEG1 impairs human liver cancer growth in mice

Hepatocellular carcinoma (HCC) is a highly aggressive form of liver cancer and one of the 5 most common cancers worldwide.

17 Feb 2009

New understanding of how leukemia develops

In a collaborative study published Feb. 9, 2009, in the Proceedings of the National Academy of Sciences (PNAS), scientists performed a genome-wide expression analysis comparing highly enriched normal blood stem cells and leukemic stem cells, and identified several new pathways that have a key role in cancer development.

9 Feb 2009

Lack of specific gene plays role in autism

It is estimated that three to six out of every 1,000 children in the United States have autism - and the number of diagnosed cases is rising.

9 Feb 2009

Missing gene plays role in autism

It is estimated that three to six out of every 1,000 children in the United States have autism - and the number of diagnosed cases is rising.

8 Feb 2009

What your mother did when she was a child may have an effect on your memory

A new study by researchers from Rush University Medical Center and Tufts University School of Medicine using mice indicate that a child's memory and the severity of learning disorders may be affected by what his or her mother did when she was a child.

3 Feb 2009

New clues to pancreatic cells' destruction in diabetes

Researchers have found what appears to be a major culprit behind the loss of insulin-producing beta cells from the pancreases of people with diabetes, a critical event in the progression of the disease.

3 Feb 2009

Century old drug clofazimine shows potential for multiple sclerosis

A century-old drug that failed in its original intent to treat tuberculosis but has worked well as an antileprosy medicine now holds new promise as a potential therapy for multiple sclerosis and other autoimmune diseases.

2 Feb 2009

Scientists develop sophisticated model to help researchers apply physics and mathematics concepts to cancer

Biology exists in a physical world. That's a fact cancer researchers are beginning to recognize as they look to include concepts of physics and mathematics in their efforts to understand how cancer develops -- and how to stop it.

2 Feb 2009

Discovery of mechanism for dental pain

Researchers at Oregon Health & Science University's School of Dentistry have discovered a novel function of the peptide known as Nerve Growth Factor (NGF) in the development of the trigeminal nerve.

8 Jan 2009

Onyx Pharmaceuticals acquires license option on novel JAK2 inhibitors from S*BIO

Onyx Pharmaceuticals, Inc. has announced that it has acquired an option to license rights to SB1518, an orally available, potent, and selective inhibitor of Janus Kinase 2 (JAK2), and SB1578, also a JAK2 inhibitor, from S*BIO Pte Ltd based in Singapore.

6 Jan 2009

Extract from grapes kills lab leukemia cells, proving value of natural compounds

An extract from grape seeds forces laboratory leukemia cells to commit cell suicide, according to researchers from the University of Kentucky.

1 Jan 2009

High-fat diet can disrupt our biological clock

Indulgence in a high-fat diet can not only lead to overweight because of excessive calorie intake, but also can affect the balance of circadian rhythms - everyone's 24-hour biological clock, Hebrew University of Jerusalem researchers have shown.

29 Dec 2008

Scientists find gene that is a powerful predictor of colon cancer metastasis

Cancer researchers have identified a gene which enables them to predict for the first time with high probability if colon cancer is going to metastasize.

22 Dec 2008

Possible new therapeutic target for pancreatic cancer

A possible new therapeutic target for pancreatic cancer, the most lethal form of human cancer, has been identified in the proteins whose DNA recipe comes from gene, "Seven-In-Absentia," according to researchers at the American Society for Cell Biology (ASCB) 48th Annual Meeting, Dec. 13-17, 2008 in San Francisco.

14 Dec 2008