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A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Recently, scientists have developed a bacterial two-hybrid (B2H) system to study the PPIs of SARS-CoV-2 in a heterologous non-eukaryotic system. This study is available on the bioRxiv* preprint server. Put simply, the B2H system could be used to analyze the SARS-CoV-2 proteome.

11 Oct 2021

Plasmonic sensing of isothermally amplified nucleic acids and single-molecule detection of SARS-CoV-2

A new study finds that plasmonic sensing of LAMP amplicons through DNA hybridization enables highly specific detection of SARS-CoV-2 RNA.

11 Oct 2021

Study identifies cells that may play a pivotal role in fibrotic scarring after lung transplant

A lung transplant can mean the difference between life and death for people with diseases such as pulmonary fibrosis, chronic obstructive pulmonary disease (COPD) and even severe COVID-19.

8 Oct 2021

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

In this review, researchers summarized the therapeutic and pathogenic role of IL-7 in patients with COVID-19 and examined the promising role of IL-7 as a vaccine adjuvant.

7 Oct 2021

Mouse brain atlas may help understand the complex circuits of the human brain

The circuits of the human brain contain more than 100 billion neurons, each linked to many other neurons via thousands of synaptic connections, resulting in a three-pound organ that is profoundly more complex than the sum of its innumerable parts.

7 Oct 2021

Enisamium shows potential as antiviral therapy for COVID-19

Researchers studied the effect of enisamium on the growth and proliferation of Caco-2 and normal human bronchial epithelial cells.

6 Oct 2021

Rapid molecular assay to detect SARS-CoV-2-specific RNA sequences

The study reported rapid detection of SARS-CoV-2 with high sensitivity and specificity in clinical samples.

6 Oct 2021

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

In a recent study published in CANCER RESEARCH , a team led by researchers at Tokyo Medical and Dental University (TMDU) identified a specific small RNA molecule, called a microRNA (miRNA or miR), that has the potential to be used as an anti-cancer therapeutic.

5 Oct 2021

Three U of U Health researchers win the 2021 NIH Director’s New Innovator Award

The National Institutes of Health has awarded grants to three University of Utah Health scientists through its competitive High-Risk, High-Reward Research (HRHR) program that funds highly innovative and unusually impactful biomedical or behavioral research proposed by extraordinarily creative scientists.

5 Oct 2021

What makes SARS-CoV-2 variants more virulent?

Researchers in the Republic of Korea have conducted a study of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – that could help to inform further studies investigating the increased virulence of variants of concern and interest.

4 Oct 2021

Advanced technique offers new insights about the dynamics of gliomas

A team led by researchers at Weill Cornell Medicine, the New York Genome Center, Harvard Medical School, Massachusetts General Hospital and the Broad Institute of MIT and Harvard has profiled in unprecedented detail thousands of individual cells sampled from patients' brain tumors.

2 Oct 2021

Non-severe COVID-19 may elicit more durable memory B cell response than severe COVID-19

A recent study conducted by researchers from the US aimed to measure the impact of severity of COVID-19 on memory B cell response and characterize changes in the memory B cell compartment during the period between recovery and five months after symptom onset. This study is available on the bioRxiv* preprint server.

30 Sep 2021

The applications of nanomaterials against viral disease

The application of nanomaterials in the diagnosis, prevention, and treatment of viral diseases is reviewed in detail, highlighting areas of significant progress or stagnation from the past few decades.

30 Sep 2021

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Oncotarget published "Pan-drug and drug-specific mechanisms of 5-FU, irinotecan (CPT-11), oxaliplatin, and cisplatin identified by comparison of transcriptomic and cytokine responses of colorectal cancer cells" which reported that there was an increase in IL-8 by oxaliplatin and increase in ferritin by cisplatin which may contribute to cancer cell survival.

29 Sep 2021

Study shows Delta variant is main variant causing vaccine breakthrough COVID-19 infections, irrespective of manufacturer

In a recent study, researchers from Texas assessed the incidence of new SARS-CoV-2 variants of concern in the communities in Dallas-Fort Worth (DFW).

28 Sep 2021

Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows

When people think of DNA, they visualize a string-like double helix structure. In reality, the DNA double helix in cells is supercoiled and constrained into loops. This supercoiling and looping are known to influence every aspect of DNA activity, but how this happens has not been clear.

28 Sep 2021

COVID-19 vaccination reduces risk and duration of SARS-CoV-2 infection

In a study conducted at the European Institute of Oncology, scientists have found that the risk and duration of SARS-CoV-2 infection reduced significantly after COVID-19 vaccination.

28 Sep 2021

Research reveals nucleolar RNA interference based on C. elegans as a model organism

A research group led by Prof. GUANG Shouhong from the University of Science and Technology of China (USTC) of the Chinese Academy of Sciences, collaborating with Prof. FENG Xuezhu from the First Affiliated Hospital of USTC, revealed the nucleolar RNA interference based on Caenorhabditis elegans (C. elegans) as a model organism. The study was published in Nuclear Acids Research.

28 Sep 2021

Researchers discover protein previously unknown to be involved in SARS-CoV-2 infection

Researchers in the UK and Germany have provided evidence for a novel mechanism by which severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) – the agent that causes coronavirus disease 2019 (COVID-19) – binds to human host cells.

27 Sep 2021

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

A new review article investigates the clinical and viral characteristics, pathogenesis, as well as human genetic basis associated with COVID-19.

27 Sep 2021

Transcription News and Research

A new bacterial two-hybrid assay to study SARS-CoV-2 interactome

Plasmonic sensing of isothermally amplified nucleic acids and single-molecule detection of SARS-CoV-2

Study identifies cells that may play a pivotal role in fibrotic scarring after lung transplant

Critical function of IL-7 in diagnosis, prognosis, and treatment of COVID-19 patients

Mouse brain atlas may help understand the complex circuits of the human brain

Enisamium shows potential as antiviral therapy for COVID-19

Rapid molecular assay to detect SARS-CoV-2-specific RNA sequences

Study identifies specific small RNA molecule that can reduce levels of cancer-promoting gene

Three U of U Health researchers win the 2021 NIH Director’s New Innovator Award

What makes SARS-CoV-2 variants more virulent?

Advanced technique offers new insights about the dynamics of gliomas

Non-severe COVID-19 may elicit more durable memory B cell response than severe COVID-19

The applications of nanomaterials against viral disease

Researchers compare transcriptomic and cytokine responses of colorectal cancer cells

Study shows Delta variant is main variant causing vaccine breakthrough COVID-19 infections, irrespective of manufacturer

Supercoiling and looping can transmit mechanical stress along the DNA backbone, research shows

COVID-19 vaccination reduces risk and duration of SARS-CoV-2 infection

Research reveals nucleolar RNA interference based on C. elegans as a model organism

Researchers discover protein previously unknown to be involved in SARS-CoV-2 infection

Review of COVID-19 clinical and viral characteristics, pathogenesis, and genetics

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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