Genetic News and Research

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Genetic basis for height and body mass differences found between European populations

University of Queensland scientists have found a genetic basis for height and body mass differences between European populations.

15 Sep 2015

African-American men at increased risk of dying of prostate cancer than Caucasian men

African-American men are more than twice as likely to die of prostate cancer compared to Caucasian men. World renowned robotic prostate surgeon, Dr. David Samadi, encourages them to have a complete family history of prostate cancer as part of their prevention plan.

15 Sep 2015

Experts provide insights on role of genetic testing in diagnosis and care of pediatric epilepsy

The steps involved in evaluating and diagnosing patients with epilepsy are complicated. In a new and extensive literature review of available information, experts provide insights on the valuable role of genetic testing in the diagnosis and care of pediatric epilepsy.

15 Sep 2015

Cardiovascular disease morbidity is significantly reduced through intensive management of blood pressure

According to initial results of a multi-site landmark study, led by Dominic Raj, M.D., at the George Washington University (GW) site, cardiovascular disease morbidity is significantly reduced through intensive management of high blood pressure.

15 Sep 2015

Study shows link between impaired mitochondria, energy failure, and neuronal dysfunction

A new study from the Gladstone Institutes shows for the first time that impairments in mitochondria--the brain's cellular power plants--can deplete cellular energy levels and cause neuronal dysfunction in a model of neurodegenerative disease.

15 Sep 2015

Study reveals how leukemia cells evade deadly effects of BRD4 inhibitors

BRD4 inhibitors are among the most promising new agents in cancer therapy that are currently evaluated in clinical trials.

15 Sep 2015

$Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture$

Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture

Using extensive genetic data compiled by the UK10K project, an international team of researchers led by Dr. Brent Richards of the Lady Davis Institute at the Jewish General Hospital has identified a genetic variant near the gene EN1 as having the strongest effect on bone mineral density (BMD) and fracture identified to date.

15 Sep 2015

Molecular biology research holds promise in understanding cancer growth, aging

Researchers at the Johns Hopkins University have found molecular evidence of how a biochemical process controls the lengths of protective chromosome tips, a potentially significant step in ultimately understanding cancer growth and aging.

15 Sep 2015

BfArM approves Greenovation’s moss-aGal phase I clinical trial for Fabry disease

Greenovation Biotech GmbH announced today that it has received approval to begin a phase I clinical trial in Europe for its first drug candidate moss-aGal (agalsidase) from Germany's regulatory authority, the Federal Institute for Drugs and Medical Devices (BfArM).

15 Sep 2015

Combining epigenetic drugs with immunotherapies may provide additional clinical benefit to cancer patients

Recent data suggest that epigenetic therapies are likely to provide additional clinical benefit to cancer patients when rationally combined with immunotherapeutic drugs, according to a review published in Clinical Cancer Research, a journal of the American Association for Cancer Research.

15 Sep 2015

Location-dependent pattern in cilia length in mouse nasal cavity affects sensitivity to odors

Like the hairs they resemble, cilia come in all lengths, from short to long. But unlike the hair on our heads, the length of sensory cilia on nerve cells in our noses is of far more than merely cosmetic significance. A team of researchers from the Perelman School of Medicine at the University of Pennsylvania found a location-dependent pattern in cilia length in the mouse nasal cavity that affects sensitivity to odors.

14 Sep 2015

Communicating risk status to at-risk Alzheimer's patients

How would you feel, as a cognitively healthy person, if a doctor said you had high odds of developing Alzheimer's disease within two to five years?

14 Sep 2015

Genetics and race influence patients' response to anticancer drug treatments

A new study published in Pharmacogenomics suggests that a person's response to anticancer drug treatments is strongly related to their genetic ancestry. Pharmacogenomics is published by Future Science Group.

14 Sep 2015

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Genetics researchers from Case Western Reserve School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer.

14 Sep 2015

Two St. Louis institutions collaborate to create Center for Clinical Pharmacology

St. Louis College of Pharmacy and Washington University School of Medicine in St. Louis are joining forces to find better, safer and more effective ways to use prescription medications to improve health. Researchers from the two institutions are collaborating to create the Center for Clinical Pharmacology.

14 Sep 2015

Interpregnancy intervals may increase autism risk, shows Kaiser Permanente study

Second-born children who are conceived sooner than two years or later than six years after the arrival of their older sibling have a substantially increased risk of autism spectrum disorders, according to a new Kaiser Permanente study published in the journal Pediatrics.

14 Sep 2015

Caltech researchers find antibody that can detect, neutralize HIV viruses in infected patients

Proteins called broadly neutralizing antibodies (bNAbs) are a promising key to the prevention of infection by HIV, the virus that causes AIDS. bNAbs have been found in blood samples from some HIV patients whose immune systems can naturally control the infection.

14 Sep 2015

Genetic mutations in deadly Ebola virus appear to block antibody-based treatments

Genetic mutations called "escape variants" in the deadly Ebola virus appear to block the ability of antibody-based treatments to ward off infection, according to a team of U.S. Army scientists and collaborators. Their findings, published online this week in the journal Cell Reports, have implications for the continued development of therapeutics to treat Ebola virus disease, which has claimed the lives of over 11,000 people in West Africa since last year.

14 Sep 2015

Mirati to present data on tyrosine kinase inhibitor at ESMO 2015 European Cancer Congress

Mirati Therapeutics, Inc., an oncology company focusing on genetic and epigenetic drivers of cancer, today announced it will present data on its tyrosine kinase inhibitor, MGCD516, at the ESMO 2015 European Cancer Congress being held in Vienna, Austria from September 25-29, 2015.

11 Sep 2015

Penn Medicine researchers show that DNA editing errors can lead to cancer

Sometimes when the immune system makes small mistakes, the body amplifies its response in a big way: Editing errors in the DNA of developing T and B cells can cause blood cancers. Now, researchers from the Perelman School of Medicine, University of Pennsylvania have shown that when the enzyme key to cutting and pasting segments of DNA hits so-called "off-target" spots on a chromosome, the development of immune cells can lead to cancer in animal models.

11 Sep 2015

Genetic News and Research

Genetic basis for height and body mass differences found between European populations

African-American men at increased risk of dying of prostate cancer than Caucasian men

Experts provide insights on role of genetic testing in diagnosis and care of pediatric epilepsy

Cardiovascular disease morbidity is significantly reduced through intensive management of blood pressure

Study shows link between impaired mitochondria, energy failure, and neuronal dysfunction

Study reveals how leukemia cells evade deadly effects of BRD4 inhibitors

Whole-genome sequencing identifies EN1 gene as determinant of bone mineral density, fracture

Molecular biology research holds promise in understanding cancer growth, aging

BfArM approves Greenovation’s moss-aGal phase I clinical trial for Fabry disease

Combining epigenetic drugs with immunotherapies may provide additional clinical benefit to cancer patients

Location-dependent pattern in cilia length in mouse nasal cavity affects sensitivity to odors

Communicating risk status to at-risk Alzheimer's patients

Genetics and race influence patients' response to anticancer drug treatments

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Two St. Louis institutions collaborate to create Center for Clinical Pharmacology

Interpregnancy intervals may increase autism risk, shows Kaiser Permanente study

Caltech researchers find antibody that can detect, neutralize HIV viruses in infected patients

Genetic mutations in deadly Ebola virus appear to block antibody-based treatments

Mirati to present data on tyrosine kinase inhibitor at ESMO 2015 European Cancer Congress

Penn Medicine researchers show that DNA editing errors can lead to cancer

eBook: Using iPSCs models for human disease research and drug discovery eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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