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Study identifies a protein and signaling pathway that may contribute to sudden cardiac death

By studying the sick hearts removed from four patients undergoing heart transplants, researchers have identified a protein and a signaling pathway that may contribute to sudden death in an inherited form of heart disease.

3 Mar 2020

Scientists find link between immune system and high blood pressure in patients with CKD

Detecting threats, sending out response molecules, and altering gene expression--our immune system works tirelessly day and night to protect us from invading pathogens and maintain general health and wellbeing.

3 Mar 2020

Study shows how cellular filament helps neural stem cells clear damaged, clumped proteins

New research by University of Wisconsin-Madison scientists reveals how a cellular filament helps neural stem cells clear damaged and clumped proteins, an important step in eventually producing new neurons.

28 Feb 2020

Bifunctional nanobodies with antitoxin potencies could protect against botulinum neurotoxins

New study reveals potential for developing novel antibody-based antitoxins against botulinum neurotoxins (BoNTs), including the most commonly used, yet most toxic one, Botox.

27 Feb 2020

Boosting immune cells to treat eczema

A new drug regimen is reported to have marked benefits in treating the troublesome and distressing skin condition called eczema. The study, published in February 2020 in the journal Science Translational Medicine, shows that boosting the levels of a type of immune cell called natural killer cells can be a more effective way to treat eczema in a mouse study.

27 Feb 2020

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Neurodegenerative diseases, like Huntington's disease and myotonic dystrophy, are often referred to as DNA repeat diseases, named because of long repeated sequences in the DNA of patients. Increasing repeat expansion length in the affected tissues contribute to earlier age of disease onset and worsen the progression and severity of the disease over time.

27 Feb 2020

Cellular metabolism plays key role in dictating the fate decision between pathogenic and regulatory T cells

Patients with autoimmune diseases like multiple sclerosis, inflammatory bowel disease and rheumatoid arthritis have an imbalance between two types of immune system T cells.

26 Feb 2020

Prolonged exposure to a pair of antioxidant proteins may fuel liver enlargement

All life is challenged by oxidants -- reactive molecules or compounds that remove electrons from other molecules -- often with adverse effect, commonly referred to as oxidative stress.

25 Feb 2020

A promising new oral therapy to speed up healing of broken bones

People with diabetes are at a higher risk of fracturing a bone than the general population. And if they do break one it also takes longer than normal to heal.

24 Feb 2020

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

Researchers identified a group of small molecules that may open the door to developing new therapies for Duchenne muscular dystrophy, an as-yet-uncured disease that results in devastating muscle weakening and loss.

24 Feb 2020

A highly conserved protein contributes to sensing mechanical pain, study shows

Researchers at McGill University have discovered that a protein found in the membrane of our sensory neurons are involved in our capacity to feel mechanical pain, laying the foundation for the development of powerful new analgesic drugs.

24 Feb 2020

Breast cancer cells hibernate in the lung before forming secondary tumors

Healthy lung cells support the survival of breast cancer cells, allowing them to hibernate in the lung before forming secondary tumors, according to new research from the Crick.

24 Feb 2020

Researchers map the cellular diversity of entire salivary gland tumors

What goes on inside and between individual cells during the very earliest stages of tumor development? Single cell sequencing technologies and a mouse model have enabled researchers to comprehensively map the cellular diversity of whole salivary gland tumors and trace the path of cancer stem cells.

20 Feb 2020

New breakthrough offers hope for potential treatment of rare childhood epilepsy

Seizure disorders in babies are frightening and heartbreaking. A new basic science breakthrough offers hope for a potential treatment for rare developmental and epileptic encephalopathies resulting from a single genetic mutation.

20 Feb 2020

Scientists discover novel molecular pathway involved in immunotherapy response

Scientists at The Wistar Institute discovered a novel pathway that enables detection of DNA in the cytoplasm and triggers inflammation and cellular senescence.

20 Feb 2020

Single gene cluster loss promotes initiation and progression of multiple myeloma in mice

The loss of one copy of the miR15a/miR16-1 gene cluster promoted initiation and progression of multiple myeloma in mice.

20 Feb 2020

Researchers identify possible new therapy for concussion-related headaches

As she jumped to head a soccer ball during her junior year of college, Kelly Farrell collided skulls with a teammate. She later was diagnosed with a concussion, which proved to be severely debilitating.

19 Feb 2020

BPA-free plastic products aren't safe for people to use, scientists warn

Using "BPA-free" plastic products could be as harmful to human health -- including a developing brain -- as those products that contain the controversial chemical, suggest scientists in a new study led by the University of Missouri and published in the Proceedings of the National Academy of Sciences.

19 Feb 2020

Pancreatic cancer 'time machine' reveals tumor development and invasion

Pancreatic cancer has one of the worst survival rates among cancers. Patients can expect as low as a 9% chance to live for at least five years after being diagnosed.

18 Feb 2020

Potential method for better treatment of premature babies

A new study published in the journal Immunology in February 2020 reports the discovery of a process that occurs in the body naturally, but which enhances the production of type 3 innate lymphoid cells (ILCs) in the lung alveoli of premature babies. These are sentinel cells that keep the mucosal surfaces clean and healthy. They are crucial to building resistance to infection within the human body.

18 Feb 2020

Mouse Model News and Research

Study identifies a protein and signaling pathway that may contribute to sudden cardiac death

Scientists find link between immune system and high blood pressure in patients with CKD

Study shows how cellular filament helps neural stem cells clear damaged, clumped proteins

Bifunctional nanobodies with antitoxin potencies could protect against botulinum neurotoxins

Boosting immune cells to treat eczema

Scientists reveal ability to reverse Huntington's disease-causing DNA repeat mutations in the lab

Cellular metabolism plays key role in dictating the fate decision between pathogenic and regulatory T cells

Prolonged exposure to a pair of antioxidant proteins may fuel liver enlargement

A promising new oral therapy to speed up healing of broken bones

Small molecules may open the door to new therapies for Duchenne muscular dystrophy

A highly conserved protein contributes to sensing mechanical pain, study shows

Breast cancer cells hibernate in the lung before forming secondary tumors

Researchers map the cellular diversity of entire salivary gland tumors

New breakthrough offers hope for potential treatment of rare childhood epilepsy

Scientists discover novel molecular pathway involved in immunotherapy response

Single gene cluster loss promotes initiation and progression of multiple myeloma in mice

Researchers identify possible new therapy for concussion-related headaches

BPA-free plastic products aren't safe for people to use, scientists warn

Pancreatic cancer 'time machine' reveals tumor development and invasion

Potential method for better treatment of premature babies

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