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Buck study uncovers how astrocyte senescence promotes neurodegeneration

Although a link has been established between chronic inflammation and neurodegenerative diseases, there have been many open questions regarding how cellular senescence, a process whereby cells that stop dividing under stress spew out a mix of inflammatory proteins, affects these pathologies.

29 Jan 2020

Research uncovers disease-aggravating mutation in mouse model of GRACILE syndrome

The new mitochondrial DNA (mtDNA) variant drastically speeds up the disease progression in a mouse model of GRACILE syndrome. This discovery provides a new tool for studies of mitochondrial diseases.

29 Jan 2020

New way to treat stroke using an already FDA-approved drug shows promise

Stroke is the third leading cause of death and disability in the United States. More than 87 percent are ischemic strokes, caused by obstruction of one or more cerebral arteries. With limited progress in developing treatments, there is a critical need for neuroprotective agents to effectively treat stroke.

29 Jan 2020

Specific gut microbes have the capacity to affect normal skeletal growth and maturation

Microbes are often seen as pathogens that cause disease, but the picture is actually more complex than that limited view.

28 Jan 2020

Non-invasive electrostimulation of the vagus nerve improves memory in mice

Researchers at UPF are testing a new non-invasive method of stimulating the vagus nerve in mice that improves their memory.

28 Jan 2020

A microdose lithium formulation could halt signs of Alzheimer's pathology

There remains a controversy in scientific circles today regarding the value of lithium therapy in treating Alzheimer's disease.

24 Jan 2020

Study sheds light on how norepinephrine release influences the fear-memory formation

Researchers at RIKEN Center for Brain Science have visualized the dynamic processes involving norepinephrine that influence different types of fear-memory formation in a living mouse model.

24 Jan 2020

Iron overload, variant gene and malaria resistance linked in African study

A new study shows that a rare genetic mutation giving rise to a variant of the TP53 gene called P47S causes several linked biological processes.

24 Jan 2020

Study reveals new "crosstalk" between intestinal microbes and developing thymic cells

Newborns face unique immunological challenges immediately after birth. As they depart a relatively sterile fetal environment, they are abruptly exposed to a multitude of foreign antigens, the major burden of which is in the form of the microbiota newly colonizing the gastrointestinal tract.

24 Jan 2020

Scientists reverse HIV latency, take major scientific step toward curative therapies

Approximately 38 million people are infected with HIV worldwide, about 1.1 million people in the United States. Currently, people with HIV take antiretroviral therapy (ART), which can suppress HIV to undetectable levels in blood, but the virus persists throughout the body in latently infected resting CD4+ T cells.

22 Jan 2020

Discovery of mechanism by which Zika virus enters brain cells

Two independent studies published by Cell Press on January 16, 2020, report that the mechanism by which Zika virus enters brain cells has been identified and even more, exploited to prevent Zika infection and to kill cancer cells instead.

16 Jan 2020

New sensitive marker may enable early diagnosis, treatment of spotted fever rickettsioses

Rickettsiae are bacteria that cause severe, potentially lethal human infections, including Mediterranean spotted fever and Rocky Mountain spotted fever.

16 Jan 2020

Researchers find potential new target for treating drug addiction

New University of Minnesota Medical School research discovers a novel potential target for treating drug addiction through "the hidden stars of the brain."

16 Jan 2020

Alcohol dependence results in remodeling of functional architecture in rodent’s brain

Employing advanced technologies that allow whole brain imaging at single-cell resolution, researchers at University of California San Diego School of Medicine report that in an alcohol-dependent mouse model, the rodent brain's functional architecture is substantially remodeled.

14 Jan 2020

The International Consortium Claims Medical Breakthrough in Malaria Research

An international consortium led by researchers in Sweden and Switzerland has conducted a genome-wide study that the team is calling a “medical breakthrough” in malaria research.

13 Jan 2020

Poor diet among infants' mothers linked to rise in Congenital Zika Syndrome cases

Congenital Zika Syndrome (CZS) refers to a collection of developmental malformations associated with Zika virus (ZIKV) congenital infection.

12 Jan 2020

Flash Radiotherapy could Deliver all the Radiation Needed in One Rapid Treatment

Researchers at the University of Pennsylvania have demonstrated that a new approach to delivering radiation could one day mean that cancer patients will be able to receive their entire course of radiotherapy within less than a second as opposed to several weeks.

10 Jan 2020

Siah2 Gene Control could Help Treat Melanomas More Effectively

To develop improved cancer immunotherapies, it is essential to understand how cancers shut down the natural immune response to foreign antigens. This current study demonstrates how mice lacking the Siah2 gene, fail to develop BRAF-mutation carrying melanoma from the corresponding cells, completely rejecting them. This could help in boosting the anticancer effect of existing specific immune checkpoint inhibitors, such as anti-PD-1 drugs.

10 Jan 2020

Sodium chloride nanoparticles offer potential for cancer therapies with fewer side effects

A new study at the University of Georgia has found a way to attack cancer cells that is potentially less harmful to the patient. Sodium chloride nanoparticles – more commonly known as salt – are toxic to cancer cells and offer the potential for therapies that have fewer negative side effects than current treatments.

9 Jan 2020

Researchers identify new prevention strategy for type 1 diabetes

A protein newly identified as important in type 1 diabetes can delay onset of the disease in diabetic mice, providing a new target for prevention and treatment in people, according to research led by scientists at the U.S. Department of Energy's Pacific Northwest National Laboratory and Indiana University School of Medicine.

9 Jan 2020

Mouse Model News and Research

Buck study uncovers how astrocyte senescence promotes neurodegeneration

Research uncovers disease-aggravating mutation in mouse model of GRACILE syndrome

New way to treat stroke using an already FDA-approved drug shows promise

Specific gut microbes have the capacity to affect normal skeletal growth and maturation

Non-invasive electrostimulation of the vagus nerve improves memory in mice

A microdose lithium formulation could halt signs of Alzheimer's pathology

Study sheds light on how norepinephrine release influences the fear-memory formation

Iron overload, variant gene and malaria resistance linked in African study

Study reveals new "crosstalk" between intestinal microbes and developing thymic cells

Scientists reverse HIV latency, take major scientific step toward curative therapies

Discovery of mechanism by which Zika virus enters brain cells

New sensitive marker may enable early diagnosis, treatment of spotted fever rickettsioses

Researchers find potential new target for treating drug addiction

Alcohol dependence results in remodeling of functional architecture in rodent’s brain

The International Consortium Claims Medical Breakthrough in Malaria Research

Poor diet among infants' mothers linked to rise in Congenital Zika Syndrome cases

Flash Radiotherapy could Deliver all the Radiation Needed in One Rapid Treatment

Siah2 Gene Control could Help Treat Melanomas More Effectively

Sodium chloride nanoparticles offer potential for cancer therapies with fewer side effects

Researchers identify new prevention strategy for type 1 diabetes

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