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March of Dimes honors Whitehead Institute Director for Developmental Biology work

Whitehead Institute Director David Page has been named a recipient of the 2011 March of Dimes Prize in Developmental Biology. The prize honors Page's groundbreaking body of research on the human Y chromosome.

22 Apr 2011

Nature solves complex topological puzzles in DNA substrate recognition with elegant simplicity

A major discovery about an enzyme's structure has opened a window on understanding DNA repair. Scientists at Duke University Medical Center have determined the structure of a nuclease that will help scientists to understand several DNA repair pathways, a welcome development for cancer research.

21 Apr 2011

US-LACRN selects Agilent gene expression microarrays for major breast cancer study

Agilent Technologies Inc. today announced that the United States-Latin American Cancer Research Network has selected Agilent Gene Expression microarrays and associated instruments for a major study of breast cancer in five Latin American nations.

21 Apr 2011

Scientists explore the role of microRNA that influences obesity-related traits

Eating more n-3 polyunsaturated fatty acids, commonly known as omega-3 fatty acids, may help carriers of a genetic variant on the perilipin 4 (PLIN4) gene locus lose weight more efficiently.

21 Apr 2011

Humans have three different gut types, finds study

In the future, when you walk into a doctor's surgery or hospital, you could be asked not just about your allergies and blood group, but also about your gut type. Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, and collaborators in the international MetaHIT consortium, have found that humans have 3 different gut types.

21 Apr 2011

Ketogenic diet may reverse impaired kidney function in diabetics

Researchers from Mount Sinai School of Medicine have for the first time determined that the ketogenic diet, a specialized high-fat, low carbohydrate diet, may reverse impaired kidney function in people with Type 1 and Type 2 diabetes. They also identified a previously unreported panel of genes associated with diabetes-related kidney failure, whose expression was reversed by the diet. The findings were published in the current issue of PLoS ONE.

21 Apr 2011

Exposure to air pollution may alter women's DNA and cause premenopausal breast cancer

Exposure to air pollution early in life and when a woman gives birth to her first child may alter her DNA and may be associated with premenopausal breast cancer later in life, researchers at the University at Buffalo have shown.

21 Apr 2011

Genes linked to obesity may also cause poor weight loss outcomes after gastric bypass surgery

Researchers at Geisinger Health System are studying how genes may affect a patient's ability to lose weight following bariatric surgery. Highlighted in the journal Obesity, the study found that several genes that promote obesity may also result in inferior weight loss outcomes after gastric bypass surgery.

21 Apr 2011

Genetically modified mosquitoes tested to prevent spread of malaria: Study

According to the latest study in the journal Nature, researchers from Imperial College London and the University of Washington, Seattle found that after making specific genetic changes to a few mosquitoes and then allowing them to breed could eventually dramatically reduce the spread of the deadly disease malaria.

20 Apr 2011

Sequencing the genomes of cancer patients help doctors decide the best course of treatment

Two new studies highlight the power of sequencing cancer patients' genomes as a diagnostic tool, helping doctors decide the best course of treatment and researchers identify new cancer susceptibility mutations that can be passed from parent to child.

20 Apr 2011

Blocking abnormal movement of mutated human FUS gene also blocks ALS process

In the first animal model of Amyotrophic Lateral Sclerosis (ALS), developed by Dr. Udai Pandey, Assistant Professor of Genetics at LSU Health Sciences Center New Orleans, Dr. Pandey's lab has found in fruit flies that blocking the abnormal movement of a protein made by a mutated gene called FUS also blocks the disease process.

20 Apr 2011

LMP1 viral protein needs TRAF6 cellular protein to promote B cell activation signaling pathways: Study

By identifying a surprising association of two intracellular proteins, University of Iowa researchers have laid the groundwork for the development of new therapies to treat B cell lymphomas and autoimmune disease.

20 Apr 2011

Consumers decide to use mail-in genetic tests based on rational and emotional reasons

Consumers decide whether to use mail-in genetic tests based on both rational and emotional reasons, a finding that adds to a growing body of health-care behavior research on information seeking and avoidance, according to researchers at the University of California, Riverside.

20 Apr 2011

Whole-genome sequencing could soon improve cancer survival rates

Cancer survival rates could improve soon with whole-genome sequencing, according to two studies published in the April 20, 2011, issue of the Journal of the American Medical Association that describe the first clinical applications of the high-tech process in patients with cancer.

20 Apr 2011

Researchers discover new way to force cancer cells to self-destruct

Researchers at The Wistar Institute have found a new way to force cancer cells to self-destruct. Low doses of one anti-cancer drug currently in development, called Gamitrinib, sensitize tumor cells to a second drug, called TRAIL, also currently in clinical development as part of an anticancer regimen.

20 Apr 2011

New method allows single microchip to screen tens of thousands of genes simultaneously

RNA interference technology, which is used in cell biology, has revolutionised functional research of the gene products in the last ten years. VTT Technical Research Centre of Finland has developed a method which allows a single microchip to be used to screen the functions of tens of thousands of genes simultaneously by means of RNA interference.

20 Apr 2011

Squamous cell cancers can originate from hair follicle stem cells, finds study

Squamous cell cancers, which can occur in multiple organs in the body, can originate from hair follicle stem cells, a finding that could result in new strategies to treat and potentially prevent the disease, according to a study by researchers with UCLA's Jonsson Comprehensive Cancer Center and the Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research at UCLA.

20 Apr 2011

Chronic inflammation due to infection may lead to cancer

A new study shows how inflammation can help cause cancer. Chronic inflammation due to infection or to conditions such as chronic inflammatory bowel disease is associated with up to 25 percent of all cancers.

20 Apr 2011

Plant hormone auxin acts as a signalling molecule in embryo development

During the development of organisms, a particular event repeatedly occurs: a signal appears temporarily, but the processes it triggers must be maintained - for example, when the fate of cells in the embryo is established.

20 Apr 2011

Parents open to genetic tests for children

Genetic testing techniques have not been perfected yet but parents are willing to take the risk to know if their children are at risk for diseases in adulthood. Some parents would like the ability to predict the future, in terms of their child's risk for certain chronic health conditions. This comes in a new study published online in the journal Pediatrics. Experts, however, say the tests are of little value at this time.

19 Apr 2011

Genes News and Research

March of Dimes honors Whitehead Institute Director for Developmental Biology work

Nature solves complex topological puzzles in DNA substrate recognition with elegant simplicity

US-LACRN selects Agilent gene expression microarrays for major breast cancer study

Scientists explore the role of microRNA that influences obesity-related traits

Humans have three different gut types, finds study

Ketogenic diet may reverse impaired kidney function in diabetics

Exposure to air pollution may alter women's DNA and cause premenopausal breast cancer

Genes linked to obesity may also cause poor weight loss outcomes after gastric bypass surgery

Genetically modified mosquitoes tested to prevent spread of malaria: Study

Sequencing the genomes of cancer patients help doctors decide the best course of treatment

Blocking abnormal movement of mutated human FUS gene also blocks ALS process

LMP1 viral protein needs TRAF6 cellular protein to promote B cell activation signaling pathways: Study

Consumers decide to use mail-in genetic tests based on rational and emotional reasons

Whole-genome sequencing could soon improve cancer survival rates

Researchers discover new way to force cancer cells to self-destruct

New method allows single microchip to screen tens of thousands of genes simultaneously

Squamous cell cancers can originate from hair follicle stem cells, finds study

Chronic inflammation due to infection may lead to cancer

Plant hormone auxin acts as a signalling molecule in embryo development

Parents open to genetic tests for children

eBook: Using iPSCs models for human disease research and drug discovery eBook

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