Chromatin Immunoprecipitation (ChIP) News and Research

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Scientists map molecular "master regulator" of fat-cell biology

A research team led by Mitchell Lazar, MD, PhD, Director of the Institute for Diabetes, Obesity, and Metabolism at the University of Pennsylvania School of Medicine, has used state-of-the-art genetic technology to map thousands of positions where a molecular "master regulator" of fat-cell biology is nestled in DNA to control genes in these cells.

5 Nov 2008

Good genes behaving badly behind type 1 diabetes

Investigators combing the genome in the hope of finding genetic variants responsible for triggering early-onset diabetes may be looking in the wrong place, new research at the Stanford University School of Medicine suggests.

31 Oct 2008

Vaccinating new mothers and other family members against influenza offers important flu protection to newborns

Vaccinating new mothers and other family members against influenza before their newborns leave the hospital creates a "cocooning effect" that may shelter unprotected children from the flu, a virus that can be life-threatening to infants, according to researchers at Duke Children's Hospital.

26 Oct 2008

Human rhinovirus found to manipulate genes

Sneezing, runny nose and chills? You might blame the human rhinovirus (HRV), which causes 30 to 50 percent of common colds. But in reality, it's not the virus itself but HRV's ability to manipulate your genes that is the true cause of some of the most annoying cold symptoms.

26 Oct 2008

$2 egg-beater - low-cost centrifuge replacement - could save lives in developing countries

Plastic tubing taped to a handheld egg-beater could save lives in developing countries, the Royal Society of Chemistry's journal Lab on a Chip reports.

16 Oct 2008

GE announces battery-free RFID sensor

GE Global Research has announced a battery-free, multi-detection radio-frequency identification (RFID) sensing platform that could enable a wide range of low cost wireless sensing products in healthcare, security, food packaging, water treatment and pollution prevention. GE's unique RFID sensors are built on traditional RFID tags.

14 Oct 2008

Statin-induced muscle disorders are focus of $2.5 million in grants from NIH

Approximately 200,000 of the 38 million people in the U.S. who take statins to treat high cholesterol may develop life-threatening muscle disease.

2 Oct 2008

Democratic Vice Presidential Nominee Biden discusses health care proposal of GOP Presidential Nominee McCain

Democratic vice presidential nominee Sen. Joseph Biden (Del.) on Tuesday during a campaign event in Mehlville, Mo., said that Republican presidential nominee Sen. John McCain (Ariz.) as president would place employer-sponsored health insurance at risk, the St. Louis Post-Dispatch reports.

11 Sep 2008

Personal DNA scanning service 23andMe drops price to $399

Personal DNA scanning service 23andMe on Tuesday is scheduled to announce that it is lowering the price of its gene-mapping service from $999 to $399 in order to attract more customers and expand its database of individual genetic profiles to bolster medical research, the San Francisco Chronicle reports.

10 Sep 2008

Discovery of novel candidate gene for inflammatory bowel diseases

A study of Crohn's disease and ulcerative colitis in children has identified a gene that influences whether children get these diseases early in life, and points to a potential new target for treatment.

2 Sep 2008

Anti-itching drug clemizole shows promise against hepatitis C

The fight against the liver disease hepatitis C has been at something of an impasse for years, with more than 150 million people currently infected, and traditional antiviral treatments causing nasty side effects and often falling short of a cure. Using a novel technique, medical and engineering researchers at Stanford University have discovered a vulnerable step in the virus' reproduction process that in lab testing could be effectively targeted with an obsolete antihistamine.

31 Aug 2008

Early trigger for type-1 diabetes found in mice

Scientists at the Stanford University School of Medicine are shedding light on how type-1 diabetes begins.

26 Aug 2008

BioNanomatrix awarded NIH grant for nanoscale platform for single-molecule DNA mapping

BioNanomatrix, Inc. has announced receipt of a grant from the National Human Genome Research Institute of the U.S. National Institutes of Health (NIH). Under the direction of BioNanomatrix principal investigator Dr. Ming Xiao, the two-year $399,020 project will develop a nanoscale platform for single-molecule haplotyping imaging and analysis of long strands of DNA at ultra-high resolution in a massively parallel format.

6 Aug 2008

Potato chip companies forced to reduce levels of cancer causing chemical in their products

Four American food manufacturers, who were taken to court because their products contained high levels of a cancer causing chemical, have reached a settlement with the state of California.

4 Aug 2008

Scientists develop ultra-sensitive optical protein sensor, a first for a salivary diagnostic test

For people who dislike needles, medical tests that require a drop of saliva instead of a vial of blood will one day make a trip to a doctor or dentist much easier. But as scientists now construct the first of these saliva tests for early signs of cancer and other diseases, they continue to push the technological envelope in interesting ways.

3 Aug 2008

Genetic mechanisms at play in blood cells important in Parkinson’s disease

What does the genetics of blood cells have to do with brain cells related to Parkinson's disease? From an unusual collaboration of neurologists and a pharmacologist comes the surprising answer: Genetic mechanisms at play in blood cells also control a gene and protein that cause Parkinson's disease.

21 Jul 2008

Discover of key patterns in gene packaging

Although every cell of our bodies contains the same genetic instructions, specific genes typically act only in specific cells at particular times. Other genes are "silenced" in a variety of ways. One mode of gene silencing depends upon the way DNA, the genetic material, is packed in the nucleus of cells.

13 Jul 2008

A micro-sized sewing machine for DNA

Japanese scientists have made a micro-sized sewing machine to sew long threads of DNA into shape. The work published in the Royal Society of Chemistry journal Lab on a Chip demonstrates a unique way to manipulate delicate DNA chains without breaking them.

10 Jul 2008

Circulating tumor cells can reveal genetic signature of dangerous lung cancers

Using a miniature laboratory-on-a-chip device, a team of investigators at the Massachusetts General Hospital, led by Daniel Haber, M.D., Ph.D., and Mehmet Toner, Ph.D., both members of the MIT-Harvard Center for Cancer Nanotechnology Excellence (CCNE), has developed a method that detects and analyzes the genetic signature of rare tumor cells in the bloodstream.

9 Jul 2008

Microchip-based device determines the genetic signature of lung tumors

Massachusetts General Hospital (MGH) investigators have shown that an MGH-developed, microchip-based device that detects and analyzes tumor cells in the bloodstream can be used to determine the genetic signature of lung tumors, allowing identification of those appropriate for targeted treatment and monitoring genetic changes that occur during therapy. A pilot study of the device called the CTC-chip will appear in the July 24 New England Journal of Medicine and is receiving early online release.

3 Jul 2008