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Study finds links between human genetic variation, gut mycobiome, and chronic disease risk

Clinicians' ability to diagnose and treat chronic diseases is limited by scientific uncertainty around factors contributing to disease risk. A study published September 2nd in the open-access journal PLOS Biology by Drs. Emily Van Syoc, Emily Davenport, and Seth Bordenstein at The Pennsylvania State University, United States, uncovers evidence of the first ternary relationships between human genetic variation, variation in gut mycobiome, and risk of developing chronic disease.

2 Sep 2025

Single-cell transcriptomics reveals new players in liver regeneration

The liver is remarkable for its ability to regenerate after injury, yet when this process fails, acute liver failure (ALF) carries devastating outcomes.

2 Sep 2025

Study reveals how dormant E. coli bacteria survive antibiotics

A groundbreaking study by researchers from Wuhan University, York University (UK), and Peking University has uncovered how Escherichia coli (E. coli) persister bacteria survive antibiotics by protecting their genetic instructions.

2 Sep 2025

Exosomes carry key indicators of biological aging

A new research paper featured on the cover of Volume 17, Issue 8 of Aging (Aging-US) was published on July 30, 2025, titled "Exosomes released from senescent cells and circulatory exosomes isolated from human plasma reveal aging-associated proteomic and lipid signatures."

2 Sep 2025

Heparanase 2 emerges as key protector of blood vessel integrity

An international research team led by MDI Biological Laboratory President Hermann Haller, M.D. and postdoctoral researcher Yannic Becker, Ph.D. has discovered that a little-known molecule, heparanase 2 (Hpa2), plays a critical role in maintaining blood vessels' integrity.

2 Sep 2025

$Walking faster may protect your bones and prevent fractures$

Walking faster may protect your bones and prevent fractures

A UK Biobank study links walking pace to osteoporosis risk, revealing brisk walking may protect bones and reduce fracture likelihood, regardless of genetics.

2 Sep 2025

Can saliva and tears replace blood tests for vitamin D and glucose?

Tears and saliva may offer new ways to monitor blood glucose and vitamin D levels, suggesting less invasive methods for managing chronic health conditions.

2 Sep 2025

Research reveals molecular details of ME/CFS and long COVID

Patients with chronic fatigue syndrome/myalgic encephalomyelitis (ME/CFS) have heightened innate immune responses to bacteria, viruses, and fungi. While these responses are essential to fight infection, they can cause damage when unchecked.

1 Sep 2025

Brain pulsations driving glymphatic function differ in narcolepsy patients and healthy individuals

A hormone produced by the brain, orexin, may play a central role in the functioning of the brain’s glymphatic system, which clears waste, according to a new study from the University of Oulu.

1 Sep 2025

Can honey protect your brain? Study reviews its potential against Alzheimer's

This review examined 27 preclinical studies on honey and Alzheimer’s disease, showing honey’s bioactive compounds counter oxidative stress, inflammation, and amyloid buildup. Despite promising lab results, no human trials exist, underscoring the need for clinical research.

1 Sep 2025

How a Mediterranean diet helps women manage menopausal symptoms

A cross-sectional study of 149 postmenopausal women found that greater adherence to a modified Mediterranean diet was linked to lower odds of moderate to severe hot flashes and sexual symptoms. While psychological and physical domains showed no significant association, the results support further evaluation of diet as a non-hormonal strategy for menopausal care.

1 Sep 2025

Cancer-related nerve injury triggers inflammation and immunotherapy resistance

Cancer cells can break down the protective covers around nerves, causing nerve injury that triggers chronic inflammation leading to immune exhaustion and eventual resistance to immunotherapy, according to new research from The University of Texas MD Anderson Cancer Center.

1 Sep 2025

Drug-coated devices not associated with improved outcomes in patients with peripheral artery disease

Drug-coated stents and balloons were not associated with reduced risk of amputation or improved quality of life compared with uncoated devices in two trials in peripheral artery disease (PAD), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025.

1 Sep 2025

Adding aspirin raises cardiovascular events in high-risk CCS patients on anticoagulants

Adding aspirin increased the risk of cardiovascular events, death and major bleeding in high-risk patients with chronic coronary syndrome (CCS) who had prior stenting and were receiving long-term chronic oral anticoagulation (OAC), according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

Extended apixaban therapy lowers recurrent VTE in patients with provoked events and enduring risk factors

Apixaban 2.5 mg twice daily significantly reduced symptomatic venous thromboembolism (VTE) recurrence, with a low risk of major bleeding, in patients with provoked VTE and enduring risk factors, according to late-breaking research presented in a Hot Line session today at ESC Congress 2025 and simultaneously published in New England Journal of Medicine.

1 Sep 2025

Lubiprostone shows promise in slowing kidney disease progression

Chronic kidney disease (CKD) is a major health issue worldwide. Many patients end up requiring regular dialysis to avoid kidney failure and stay alive.

1 Sep 2025

Can oral bacteria make heart disease worse?

The presence of viridans streptococci in coronary plaques indicates a role in atherosclerosis, potentially influencing heart disease outcomes.

1 Sep 2025

New ESC guidelines introduce unified approach to improve myocarditis and pericarditis care

New ESC Guidelines to improve the diagnosis and care of patients with myocarditis and pericarditis, have been published today at ESC Congress 2025.

30 Aug 2025

New off-the-shelf immunotherapy for metastatic kidney cancer could help improve outcomes

UCLA researchers have developed a new kind of immunotherapy that uses specially engineered immune cells equipped with built-in weapons to attack kidney cancer tumors and reprogram their protective environment - all without the need to customize treatment for each individual patient.

29 Aug 2025

Constipation drug found to slow renal function decline in CKD patients

Chronic kidney disease (CKD) is a major health issue worldwide. Many patients end up requiring regular dialysis to avoid kidney failure and stay alive.

29 Aug 2025