Clinical Trial News and Research

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UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

In an effort to combat one of the most lethal forms of pediatric brain cancer, researchers at the UCLA Health Jonsson Comprehensive Cancer Center are launching a first-of-its-kind clinical trial to evaluate the safety and effectiveness of a cancer vaccine targeting H3 G34-mutant diffuse hemispheric glioma, a highly aggressive brain tumor that is typically found in adolescents and young adults.

5 Aug 2024

Quality-of-life measurements are essential in cancer care, study says

As novel cancer treatments continually emerge, it is essential to collect data on patients' quality of life along with how the treatment is working to extend survival.

5 Aug 2024

Cannabigerol shows promise in reducing anxiety and stress, study finds

Whether the phytocannabinoid cannabigerol impacted mood, stress, and anxiety and caused any related adverse effects of cognitive or motor impairment.

5 Aug 2024

Study finds fourfold increase in risk of overt hypothyroidism after diagnosis of gestational subclinical hypothyroidism

A new study has shown that subclinical hypothyroidism diagnosed before 21 weeks of pregnancy is associated with more than fourfold higher rates of overt hypothyroidism or thyroid replacement therapy within 5 years of delivery.

2 Aug 2024

FDA grants accelerated approval for first engineered T cell therapy to treat adults with synovial sarcoma

The U.S. Food and Drug Administration (FDA) has granted accelerated approval for the immunotherapy afamitresgene autoleuecel (Tecelra®, also known as afami-cel) for the treatment of adults with a rare soft tissue cancer called synovial sarcoma.

2 Aug 2024

Triptolide-based treatment prolongs symptom-free survival in preclinical medulloblastoma models

A drug that was developed to treat pancreatic cancer has now been shown to increase symptom-free survival in preclinical medulloblastoma models – all without showing signs of toxicity.

1 Aug 2024

Fish oil may benefit older adults with genetic Alzheimer's risk

A clinical trial at Oregon Health & Science University suggests that a subset of older adults with a genetic predisposition to Alzheimer's disease may benefit from fish oil supplements.

1 Aug 2024

FDA clears UAB startup's TIX100 for clinical trials

The University of Alabama at Birmingham startup TIXiMED, Inc., has obtained clearance from the United States Food and Drug Administration to proceed to clinical trials under an Investigational New Drug for TIX100, its novel oral Type 1 diabetes drug.

31 Jul 2024

Study finds cannabigerol effectively reduces anxiety, boosts memory recall

A lesser-known cannabinoid that is gaining in popularity Cannabigerol (CBG) effectively reduced anxiety in a clinical trial without the intoxication typically associated with whole plant cannabis.

31 Jul 2024

Medical device may aid stroke survivors during heart valve replacement procedure

Recently published research shows a medical device may be beneficial for patients who have previously had a stroke and are planning to undergo a transcatheter aortic valve replacement, a type of heart valve operation.

31 Jul 2024

2024 is shaping up to be “the year of iPSCs"

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From Axol Bioscience Ltd 31 Jul 2024

Researchers identify key genetic variants linked to ALS recovery

Though exceedingly rare, some people diagnosed with amyotrophic lateral sclerosis (ALS) partially or fully recover from the lethal neurodegenerative disease.

30 Jul 2024

New dual-chamber wireless pacemaker shows reliable performance in clinical trial

A dual-chamber wireless pacemaker provides reliable performance over three months, bolstering evidence for this new pacemaker option, according to results from a multi-center, international clinical trial co-led by a Weill Cornell Medicine and NewYork-Presbyterian investigator.

30 Jul 2024

Study reveals curcumin’s antidepressant effects in obese type 2 diabetes patients

A randomized clinical trial (RCT) to investigate the effectiveness of curcumin in lowering depression among obese individuals with diabetes mellitus type 2 (T2DM).

30 Jul 2024

Genetic variants associated with Parkinson's more common than estimated

New research has found that genetic variants associated with Parkinson's disease (PD) are more common than researchers previously believed. Investigators in the Parkinson's Foundation-backed PD GENEration study – which reached its goal of 15,000 participants ahead of schedule this spring – found that 13% of participants have a genetic form of PD, which is a significant observation compared to long-standing estimates. Results from the first 3.5 years of the study, which examined a broad North American cohort, were published in the peer-reviewed scientific journal Brain.

30 Jul 2024

Hospital-based addiction consult services show promise in improving opioid use disorder treatment uptake

Previous research has found that over 80 percent of people with opioid use disorder (OUD) do not receive evidence-based lifesaving medications.

29 Jul 2024

DNA repair gene mutations predict bladder cancer response to neoadjuvant chemotherapy

An analysis of pre-treatment tumor specimens from 105 patients with localized muscle-invasive bladder cancer found that the presence of a mutation in any one of three genes, all known to be involved in DNA damage repair, was associated with complete pathologic response to cisplatin-based neoadjuvant chemotherapy as measured by pathological downstaging at the time of bladder surgery.

29 Jul 2024

FDA-approved iron-chelating drug could provide a novel way to attack ovarian tumors

An iron-binding drug that is already approved for treatment of other diseases could provide a novel way to attack ovarian tumors, according to a new study led by Weill Cornell Medicine researchers.

29 Jul 2024

Lettuce found comparable to dock leaf for nettle sting relief

Rubbing a lettuce leaf on a nettle sting to ease the associated discomfort may be just as good as using the age-old folk remedy of a dock leaf, suggest the results of a small comparative study, published online in Emergency Medicine Journal.

29 Jul 2024

Overcoming cancer relapse with CAR-Enhancer therapy

Even as they have revolutionized the treatment of certain forms of cancer, CAR T-cell therapies have been shadowed by a significant limitation: many patients, including those whose cancer goes into full remission, eventually relapse. In a new study, Dana-Farber Cancer Institute researchers report on a technique with the potential to eliminate that problem.

29 Jul 2024

Clinical Trial News and Research

UCLA launches groundbreaking clinical trial for vaccine targeting aggressive pediatric brain cancer

Quality-of-life measurements are essential in cancer care, study says

Cannabigerol shows promise in reducing anxiety and stress, study finds

Study finds fourfold increase in risk of overt hypothyroidism after diagnosis of gestational subclinical hypothyroidism

FDA grants accelerated approval for first engineered T cell therapy to treat adults with synovial sarcoma

Triptolide-based treatment prolongs symptom-free survival in preclinical medulloblastoma models

Fish oil may benefit older adults with genetic Alzheimer's risk

FDA clears UAB startup's TIX100 for clinical trials

Study finds cannabigerol effectively reduces anxiety, boosts memory recall

Medical device may aid stroke survivors during heart valve replacement procedure

2024 is shaping up to be “the year of iPSCs"

Researchers identify key genetic variants linked to ALS recovery

New dual-chamber wireless pacemaker shows reliable performance in clinical trial

Study reveals curcumin’s antidepressant effects in obese type 2 diabetes patients

Genetic variants associated with Parkinson's more common than estimated

Hospital-based addiction consult services show promise in improving opioid use disorder treatment uptake

DNA repair gene mutations predict bladder cancer response to neoadjuvant chemotherapy

FDA-approved iron-chelating drug could provide a novel way to attack ovarian tumors

Lettuce found comparable to dock leaf for nettle sting relief

Overcoming cancer relapse with CAR-Enhancer therapy

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