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A new methodological approach to ease the synthesis of high structural complex molecules

The synthesis of complex molecules such as drugs requires a process that sometimes involves several phases that increase its cost and harden access to the product.

4 Nov 2020

Researchers investigate the effect of palm oil extract on mice liver cells

Palm oil contains abundant quantities of vitamin E compounds, which include tocopherols and tocotrienols.These compounds have anti-oxidant effects, which protect cells from damage from toxic chemical produced by metabolic processes.

4 Nov 2020

Discoverey of four SARS-CoV-2 Mpro inhibitors, boceprevir, calpain inhibitors II and XII and GC-376

A team of scientists from the United States has recently revealed that small molecule inhibitors of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) main protease exhibit potent antiviral activity. These inhibitors show better efficacy when used in combination with antiviral medicine Remdesivir. The study is currently available on the bioRxiv* preprint server.

3 Nov 2020

Novel molecules show potential for future cancer therapies

Cancers sometimes escape our immune defenses because of the over-activity of molecular signaling systems, called checkpoint processes. Now we may be able to fight back using a new range of molecules, researchers in China report in the European Journal of Medicinal Chemistry.

3 Nov 2020

Study proves how nitrate reduces blood pressure and improves oral health

The research team has patented one prebiotic compound and several probiotics with the identified molecules and bacteria.

3 Nov 2020

Engineers use electric fields to manipulate viruses in microfluidic device

The technique uses microfluidics -- the submillimeter control of fluids within a precise, geometric structure. On what is basically a tricked-out microscope slide, chemical engineers from Michigan Technological University have been able to manipulate viruses in a microfluidic device using electric fields.

3 Nov 2020

Root bacterium could provide a new approach for treatment of Alzheimer's

A bacterium found among the soil close to roots of ginseng plants could provide a new approach for the treatment of Alzheimer's.

2 Nov 2020

Novel MRI contrast agent offers hope for early detection of Alzheimer’s disease

Hong Kong Baptist University scientists have invented a novel contrast agent for magnetic resonance imaging, which enables real-time visualization and detection of the size and number of amyloid-beta in the brain, a main hallmark of Alzheimer’s disease.

2 Nov 2020

Socks coated in zinc oxide nanoparticles can prevent unpleasant foot odor

New research presented at the 29th EADV Congress, EADV Virtual, shows that socks coated in zinc oxide nanoparticles can prevent bromodosis and pitted keratolysis, reducing the negative impact this embarrassing condition has on quality of life.

2 Nov 2020

5-amino levulinic acid inhibits SARS-CoV-2 infection in vitro

Researchers tested 5-amino levulinic acid in vitro in human-derived cells and found it prevents severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. Because it is safe and ubiquitous in plants and animals, it could be a potential drug against SARS-CoV-2.

1 Nov 2020

Study: Toxins produced by tube-dwelling anemones have pharmacological potential

Researchers based in Brazil and the United States have completed the first-ever mapping exercise to profile the toxins produced by tube-dwelling anemones, or cerianthids, a family of marine animals belonging to the same phylum (Cnidaria) as sea anemones, jellyfish and corals.

30 Oct 2020

"Training" the immune system with β-glucan compound may improve immune recovery

Immunotherapies, such as checkpoint inhibitor drugs, have made worlds of difference for the treatment of cancer.Most clinicians and scientists understand these drugs to act on what's known as the adaptive immune system, the T cells and B cells that respond to specific threats to the body.

30 Oct 2020

Time machine suggests a drug testing approach for pancreatic cancer

Many patients with pancreatic cancer have only about a 10% chance of survival within five years of their diagnosis because they tend to become resistant to chemotherapy, past studies have indicated.

30 Oct 2020

Moscow scientists discover and explain the activity mechanism of new anti-cancer molecule

A group of Moscow scientists has discovered and explained the activity mechanism of a new anti-cancer molecule -- diphenylisoxazole.

29 Oct 2020

Structure and mechanisms of ribosomal frameshifting during SARS-CoV-2 translation

The structure of a 3’ stimulatory pseudoknot in the viral genome or by itself has been proposed recently. Researchers report the structure and mechanisms of mammalian ribosomes during translation of the -1 frameshifting of the SARS-CoV-2 viral genome in a new study published on the preprint server bioRxiv.

28 Oct 2020

Dietary 1H-NMR “Fingerprints” Could Help Fight Against Chronic Disease

Metabolic urine profiling could provide an approach to understand what people have been eating, without them needing to tell you. Here, researchers from Imperial College London, Prof Gary Frost, Prof Elaine Holmes, and Dr. Isabel Garcia-Perez, explain why this could be invaluable to both nutritional research and individuals.

From Bruker BioSpin Division 27 Oct 2020

Research shows wrinkled 'super pea' may reduce risk of type 2 diabetes

A type of wrinkled 'super pea' may help control blood sugar levels and could reduce the risk of type 2 diabetes, suggests a new study.

27 Oct 2020

New inhibitor of SARS-CoV-2 RNA translation

As the search for effective severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) inhibitors continues, a recent study by Yale University School of Medicine researchers published on the preprint server bioRxiv in October 2020 reports the inhibitory effect of the drug merofloxacin on frameshifting during SARS-CoV-2 replication.

26 Oct 2020

Molecular processes in kidney cells may increase diabetics' vulnerability to COVID-19 infection

People with diabetes -- especially the 20 to 40 percent with diabetic kidney disease -- are among the most at risk for serious complications and death from COVID-19.

23 Oct 2020

Researchers find a new therapeutic approach to combat leukemia

Leukemia frequently originates from the so-called leukemic stem cell, which resides in a tumor promoting and protecting niche within the bone marrow. Scientists from the Max Planck Institute of Biochemistry in Martinsried, Germany, have found a new way to make these cells vulnerable by specifically dislodging these cells from their niches.

23 Oct 2020