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RNAs emerge as major players in gene regulation

Tiny strands of genetic material called RNA - a chemical cousin of DNA - are emerging as major players in gene regulation, the process inside cells that drives all biology and that scientists seek to control in order to fight disease.

6 Jul 2008

Researchers reveal types of genes necessary for brain development

Researchers from Harvard Medical School and Brandeis University have successfully completed a full-genome RNAi screen in neurons, showing what types of genes are necessary for brain development. Details of the screen and its novel methodology are published July 4th in the open-access journal PLoS Genetics.

4 Jul 2008

New target for the potential treatment of tuberculosis

Scientists have uncovered a new target for the potential treatment of tuberculosis (TB), finally resolving a long-running debate about how the bacterial cell wall is built.

3 Jul 2008

Scientists shed new light into early mechanisms governing cardiovascular specification

The mature heart is composed by different cell types, including contractile cardiac cells, vascular cells, smooth muscle cells as well as pacemaker cells.

3 Jul 2008

Funding boost in fight against leukaemia

University of Manchester researchers have been awarded £1.6 million to study a group of genes identified as playing a key role in leukaemia.

From The University of Manchester 3 Jul 2008

Statins have unexpected effect on pool of powerful brain cells

Cholesterol-lowering drugs known as statins have a profound effect on an elite group of cells important to brain health as we age, scientists at the University of Rochester Medical Center have found. The new findings shed light on a long-debated potential role for statins in the area of dementia.

3 Jul 2008

New computational tool to study complex clusters of genes

Two Texas A&M University researchers have developed a computational tool that will help scientists more accurately study complex units of clustered genes, called operons, in bacteria.

3 Jul 2008

New insight into role of statins in dementia

3 Jul 2008

Genetic link between Crohn's and asthma discovered

Research into the genetic causes of Crohn's disease has revealed that the gene ORMDL3, known to be a risk factor for childhood asthma, is also associated with Crohn's disease, and in the process links between the condition and other diseases have been found.

2 Jul 2008

Mouse embryonic stem cells used to build heart parts

Researchers have shown that they can put mouse embryonic stem cells to work building the heart, potentially moving medical science a significant step closer to a new generation of heart disease treatments that use human stem cells.

2 Jul 2008

GILZ protein may have big role in making more bone and less fat

A small protein may have a big role in helping you make more bone and less fat, researchers say. "The pathways are parallel, and the idea is if you can somehow disrupt the fat production pathway, you will get more bone," says Dr. Xingming Shi, bone biologist at the Medical College of Georgia Institute of Molecular Medicine and Genetics.

1 Jul 2008

New technique produces genetically identical stem cells

Adult cells of mice created from genetically reprogrammed cells-so-called induced pluripotent stem (IPS) stem cells-can be triggered via drug to enter an embryonic-stem-cell-like state, without the need for further genetic alteration.

1 Jul 2008

Cancer cells revert to normal at specific signal threshold

Cancer starts when key cellular signals run amok, driving uncontrolled cell growth. But scientists at the Stanford University School of Medicine report that lowering levels of one cancer signal under a specific threshold reverses this process in mice, returning tumor cells to their normal, healthy state. The finding could help target cancer chemotherapy to tumors while minimizing side effects for the body's healthy cells.

1 Jul 2008

Electrostatic-based RNA assays technique could revolutionize medical diagnostics

The dream of personalized medicine - in which diagnostics, risk predictions and treatment decisions are based on a patient's genetic profile - may be on the verge of being expanded beyond the wealthiest of nations with state-of-the-art clinics.

30 Jun 2008

Scientists fortify the cassava plant - a day's nutrition in a single meal

Scientists have determined how to fortify the cassava plant, a staple root crop in many developing countries, with enough vitamins, minerals and protein to provide the poor and malnourished with a day's worth of nutrition in a single meal.

30 Jun 2008

Neural stem cell development may be linked to Autism

In a breakthrough scientific study published today in the Proceedings of the National Academy of Sciences, scientists at the Burnham Institute for Medical Research have shown that neural stem cell development may be linked to Autism.

30 Jun 2008

Zinc finger technology brings personalized HIV therapy a step closer

Researchers at the University of Pennsylvania School of Medicine and collaborators are using minute, naturally occurring proteins called zinc fingers to engineer T cells to one day treat AIDS in humans.

30 Jun 2008

NIAID announces grants to stimulate food allergy research

Twelve investigators have received grants totaling $5 million over two years to lead high-impact, innovative studies of food allergy, a significant public health concern.

30 Jun 2008

A global DNA barcode database

The idea of barcoding is familiar to many: in almost every supermarket the checkout operator shows the ticket labelled with a series of black bars to a laser scanner which responds with a beep; a computer analyses the code, identifies the product and the price is sent to the till.

30 Jun 2008

Growth hormone FGF21's link to starvation may be clue to increasing life span, researchers find

Researchers at UT Southwestern Medical Center have determined that starvation blocks the effects of growth hormone via a mechanism that may have implications in treating diabetes and extending life span.

30 Jun 2008