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The International Consortium Claims Medical Breakthrough in Malaria Research

An international consortium led by researchers in Sweden and Switzerland has conducted a genome-wide study that the team is calling a “medical breakthrough” in malaria research.

13 Jan 2020

Poor diet among infants' mothers linked to rise in Congenital Zika Syndrome cases

Congenital Zika Syndrome (CZS) refers to a collection of developmental malformations associated with Zika virus (ZIKV) congenital infection.

12 Jan 2020

Flash Radiotherapy could Deliver all the Radiation Needed in One Rapid Treatment

Researchers at the University of Pennsylvania have demonstrated that a new approach to delivering radiation could one day mean that cancer patients will be able to receive their entire course of radiotherapy within less than a second as opposed to several weeks.

10 Jan 2020

Siah2 Gene Control could Help Treat Melanomas More Effectively

To develop improved cancer immunotherapies, it is essential to understand how cancers shut down the natural immune response to foreign antigens. This current study demonstrates how mice lacking the Siah2 gene, fail to develop BRAF-mutation carrying melanoma from the corresponding cells, completely rejecting them. This could help in boosting the anticancer effect of existing specific immune checkpoint inhibitors, such as anti-PD-1 drugs.

10 Jan 2020

Sodium chloride nanoparticles offer potential for cancer therapies with fewer side effects

A new study at the University of Georgia has found a way to attack cancer cells that is potentially less harmful to the patient. Sodium chloride nanoparticles – more commonly known as salt – are toxic to cancer cells and offer the potential for therapies that have fewer negative side effects than current treatments.

9 Jan 2020

Researchers identify new prevention strategy for type 1 diabetes

A protein newly identified as important in type 1 diabetes can delay onset of the disease in diabetic mice, providing a new target for prevention and treatment in people, according to research led by scientists at the U.S. Department of Energy's Pacific Northwest National Laboratory and Indiana University School of Medicine.

9 Jan 2020

Targeting VEGFA signaling in the epidermis can prevent psoriasis development

Psoriasis is a frequent skin inflammatory disorder affecting 3% of the population. Psoriasis is characterized by hyperproliferation and defect of epidermal differentiation, leading to the scaly appearance of the skin. The psoriasis skin also presents an increase in blood vessels, leading to the redness of the skin lesions and is associated with immune infiltration.

9 Jan 2020

Researchers one step closer to developing vaccines that protect infants against infections

A new Penn Medicine study puts researchers within closer reach of vaccines that can protect infants against infections by overcoming a mother's antibodies, which are known to shut down immune defenses initiated by conventional vaccines.

9 Jan 2020

Cornell study details role of stem cell in deadly gastric cancer

A Cornell study provides important new insights into a common and deadly type of gastric cancer.

7 Jan 2020

Can FDA-approved flu shots be repurposed as treatments for cancer?

Changing the microenvironment of tumors to increase the immune system's response to them has been the goal of countless research and clinical studies including the most recent use of checkpoint inhibitory antibodies.

7 Jan 2020

Study shows the feasibility of using gene therapy to treat chronic traumatic encephalopathy

A new study shows the feasibility of using gene therapy to treat the progressive neurodegenerative disorder chronic traumatic encephalopathy.

3 Jan 2020

Study provides better understanding of mechanisms that limit cilia number in cells

One of the wonders of cell biology is its symmetry. Mammalian cells have one nucleus and one cell membrane, and most humans have 23 pairs of chromosomes.

30 Dec 2019

Plant-rich diet protects against foodborne pathogens, mice study shows

Mice fed a plant-rich diet are less susceptible to gastrointestinal infection from a pathogen such as the one currently under investigation for a widespread E. coli outbreak tied to romaine lettuce, UT Southwestern researchers report.

23 Dec 2019

Common immune cell linked to failure of checkpoint inhibitors in lung cancer patients

For many lung cancer patients, the best treatment options involve checkpoint inhibitors. These drugs unleash a patient's immune system against their disease and can yield dramatic results, even in advanced cancers.

19 Dec 2019

Study reveals new role for a triple-negative breast cancer target

Unlike almost every other organ, the mammary gland does not develop until after birth. And it's unusually dynamic, shape-shifting during menstrual cycles, puberty, pregnancy, and lactation.

19 Dec 2019

Scientists explore role of IgG4 Abs in IgG4-related disease

Autoimmune diseases are a medical conundrum. In people with these conditions, the immune system of the body, the designated defense system, starts attacking the cells or organs of its own body, mistaking the self-cells for invading disease-causing cells. Often, the cause for this spontaneous dysfunction is not clear, and hence, treatment of these diseases presents a major and ongoing challenge.

18 Dec 2019

Moffitt researchers develop efficient method for creating mouse models to study melanoma

Genetically engineered mouse models are often used by scientists to study how the addition, deletion or mutation of genes affects the development of disease and effects of drugs.

17 Dec 2019

Researchers identify novel genetic signature with prognostic value for certain breast cancers

Researchers have identified a genetic signature with prognostic value for certain kinds of breast cancer. The discovery also contributes to a better understanding of the molecular mechanisms of pathological angiogenesis, the aberrant proliferation of blood vessels that occurs during cancer and other diseases.

17 Dec 2019

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Investigators at the Case Western Reserve University School of Medicine discovered that blocking interleukin-1α (IL1α), a protein that controls inflammation in the gut, markedly decreases the severity of intestinal inflammation in a mouse model of Crohn's disease (CD).

17 Dec 2019

Penn researchers track defective sperm epigenome linked to male infertility

One out of eight couples has trouble conceiving, with nearly a quarter of those cases caused by unexplained male infertility. For the past decade, research has linked that infertility to defective sperm that fail to "evict" proteins called histones from DNA during development.

16 Dec 2019

Mouse Model News and Research

The International Consortium Claims Medical Breakthrough in Malaria Research

Poor diet among infants' mothers linked to rise in Congenital Zika Syndrome cases

Flash Radiotherapy could Deliver all the Radiation Needed in One Rapid Treatment

Siah2 Gene Control could Help Treat Melanomas More Effectively

Sodium chloride nanoparticles offer potential for cancer therapies with fewer side effects

Researchers identify new prevention strategy for type 1 diabetes

Targeting VEGFA signaling in the epidermis can prevent psoriasis development

Researchers one step closer to developing vaccines that protect infants against infections

Cornell study details role of stem cell in deadly gastric cancer

Can FDA-approved flu shots be repurposed as treatments for cancer?

Study shows the feasibility of using gene therapy to treat chronic traumatic encephalopathy

Study provides better understanding of mechanisms that limit cilia number in cells

Plant-rich diet protects against foodborne pathogens, mice study shows

Common immune cell linked to failure of checkpoint inhibitors in lung cancer patients

Study reveals new role for a triple-negative breast cancer target

Scientists explore role of IgG4 Abs in IgG4-related disease

Moffitt researchers develop efficient method for creating mouse models to study melanoma

Researchers identify novel genetic signature with prognostic value for certain breast cancers

Study: Blocking IL1α protein decreases severity of inflammation in Crohn's disease

Penn researchers track defective sperm epigenome linked to male infertility

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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