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Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging

Iron oxide nanoparticles have shown promise as agents for detecting tumors using magnetic resonance imaging (MRI), but such efforts have been limited by the relatively weak magnetic signal generated by these nanoparticles.

22 Jan 2007

Dendrimer-based targeted delivery of an apoptotic sensor in cancer cells

Taking a critical step toward the development of a multifunctional nanoscale anticancer agent that can detect cancer, treat it, and then report on the success or failure of that treatment, investigators at the University of Michigan have developed a nanoscale sensor of cell death.

22 Jan 2007

Microfluidics gives boost to protein crystallization

Proteins produced by cancer cells are among the common targets for anticancer agents, and thanks to efforts in proteomics and cancer genomics, the number of potential protein targets is increasing exponentially.

16 Jan 2007

Nanoparticles yield delivery tools for therapeutic nucleic acids

Cancer researchers hold great hope that nucleic acid-based therapeutics, such as anticancer genes, antisense oligonucleotides, and small interfering RNA (siRNA) molecules, will prove to be powerful antitumor agents.

16 Jan 2007

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles

Researchers at Montana State University have used an engineered form of ferritin, a cage-like iron storage protein, to both synthesize and deliver iron oxide nanoparticles to tumors.

16 Jan 2007

Biomimetic amplification of nanoparticle homing to tumors

A collaborative, multidisciplinary team of researchers has created nanoparticles that act much like a developing clot to target tumors.

16 Jan 2007

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme

Glioblastoma multiforme is among the most aggressive and difficult cancers to treat. Now, researchers at Penn State University have shown that a lipid-based nanoparticle, designed to bind to a specific receptor found on malignant brain cells but not healthy ones, improves the potency of a common anticancer drug and slows significantly the growth of glioblastoma in mice.

8 Jan 2007

A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability

In an accomplishment that represents a significant step toward an era of rapid, inexpensive, bedside testing for cancer, researchers at the University of Virginia have developed a microfluidic device that can process human blood samples and yield diagnostic results within an hour.

8 Jan 2007

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

By combining a quantum dot with a novel carrier of the magnetic resonance imaging (MRI) agent gadolinium, a team of investigators at the University of Maastricht, in The Netherlands, has developed a nanoparticle that can spot apoptosis, or programmed cell death, using both MRI and fluorescence imaging.

8 Jan 2007

Dendrimer-encapsulated camptothecins

With an eye toward developing a delivery vehicle for anticancer agents that are poorly soluble in water, a research team at Boston University and the Research Triangle Institute (RTI) has developed a biocompatible dendrimer that wraps itself around water-insoluble drugs.

8 Jan 2007

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

In the first experiment of its kind, investigators at the Center for Cancer Nanotechnology Excellence Focused on Therapy Response (CCNE-TR), based at Stanford University, have shown that single-walled carbon nanotubes (SWCNTs) wrapped in poly(ethylene glycol), or PEG, can successfully target tumors in living animals.

8 Jan 2007

Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA

Researchers from the Swiss Nanoscience Institute in Basel have developed a rapid method to detect the activity of a gene involved in controlling tumor growth.

18 Dec 2006

Characterizing the environmental, health, and safety implications of nanotechnology

A new analysis of the Federal government’s efforts to study the environmental, health, and safety (EHS) implications of nanotechnology concludes that sound management will play as important a role as good science when it comes to addressing these concerns.

18 Dec 2006

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

In an attempt to determine what factors make one nanoparticle better than another at targeting tumors, a team of investigators in Korea have conducted a systematic tumor-targeting study of a variety of self-assembling nanoparticles.

18 Dec 2006

Better magnetic nanoparticles

Using a polymer coating designed to resemble the outer surface of a cell membrane, a team of investigators led by Steve Armes, Ph.D., of the University of Sheffield in the United Kingdom, has created a highly stable, biocompatible magnetic nanoparticle expected to improve the sensitivity of magnetic resonance imaging (MRI).

18 Dec 2006

New X-ray microscope shows nanomaterials in 3D

Using a new x-ray microscope that can look at nanomaterials in three dimensions, an international research team has produced the first detailed atomic structure of a core-shell nanoparticle.

18 Dec 2006

Aptamer-capped nanocrystal quantum dots

Quantum dots, used increasingly as bright fluorescent markers in basic research and diagnostic assays, must be coated, or capped, with one of a wide variety of organic molecules in order to stabilize these nanocrystals and prevent them from aggregating when added to water.

18 Dec 2006

Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery

Though gene therapies hold great promise for treating cancer, it has proven difficult to deliver therapeutic genes efficiently into cancer cells.

18 Dec 2006

Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

In the first experiments of their kind, researchers have determined that carbon nanotubes injected directly into the bloodstream of research lab animals cause no immediate adverse health effects and circulate for more than one hour before they are removed by the liver.

18 Dec 2006

Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma

Nanoscale, inorganic fluorescent imaging agents such as quantum dots have become an important tool for researchers studying key biomolecules involved in cancer.

18 Dec 2006

Nanotechnology News and Research

Artificially engineered magnetic nanoparticles for ultra-sensitive molecular imaging

Dendrimer-based targeted delivery of an apoptotic sensor in cancer cells

Microfluidics gives boost to protein crystallization

Nanoparticles yield delivery tools for therapeutic nucleic acids

Targeting of cancer cells with ferrimagnetic ferritin cage nanoparticles

Biomimetic amplification of nanoparticle homing to tumors

Interleukin-13 receptor-targeted nanovesicles are a potential therapy for glioblastoma multiforme

A fully integrated microfluidic genetic analysis system with sample-in-answer-out capability

Optical and magnetic resonance imaging of cell death and platelet activation using annexin A5-functionalized quantum dots

Dendrimer-encapsulated camptothecins

In vivo biodistribution and highly efficient tumour targeting of carbon nanotubes in mice

Rapid and label-free nanomechanical detection of biomarker transcripts in human RNA

Characterizing the environmental, health, and safety implications of nanotechnology

In vivo tumor targeting and radionuclide imaging with self-assembled nanoparticles

Better magnetic nanoparticles

New X-ray microscope shows nanomaterials in 3D

Aptamer-capped nanocrystal quantum dots

Nanostructured calcium phosphates (NanoCaPs) for non-viral gene delivery

Mammalian pharmacokinetics of carbon nanotubes using intrinsic near-infrared fluorescence

Dual-mode nanoparticle probes for high-performance magnetic resonance and fluorescence imaging of neuroblastoma

Discover how SciY empowers scientists

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

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