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MED1 plays a central role in mediating tamoxifen resistance in breast cancer

A University of Cincinnati (UC) cancer biology team reports breakthrough findings about specific cellular mechanisms that may help overcome endocrine (hormone) therapy-resistance in patients with estrogen-positive breast cancers, combating a widespread problem in effective medical management of the disease.

3 Nov 2012

Researchers discover how tamoxifen-resistant breast-cancer cells grow and proliferate

A study by researchers at the Ohio State University Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute (OSUCCC - James) has discovered how tamoxifen-resistant breast-cancer cells grow and proliferate.

31 Oct 2012

Radiation therapy protocol deviations associated with increased risk of treatment failure and overall mortality

Radiation therapy protocol deviations in clinical trials are associated with increased risk of treatment failure and overall mortality, according to a study entitled, “Radiotherapy Protocol Deviations are Associated with Inferior Clinical Outcomes: A Meta-analysis of Cooperative Group Clinical Trials” to be presented today at the 54th annual meeting of the American Society for Radiation Oncology (ASTRO) in Boston, MA.

30 Oct 2012

AstraZeneca commences FASLODEX Phase III study for hormone receptor-positive metastatic breast cancer

AstraZeneca today announced the start of a Phase III study (FALCON), a global clinical trial which will involve 450 postmenopausal patients with hormone receptor-positive locally advanced or metastatic breast cancer who have not previously been treated with any hormonal therapy. The Phase III study is designed to evaluate the efficacy and tolerability of fulvestrant 500 mg compared to anastrozole 1 mg in this patient population.

29 Oct 2012

Study indicates that Firemaster 550 is an endocrine disruptor

The flame-retardant mixture known as "Firemaster 550" is an endocrine disruptor that causes extreme weight gain, early onset of puberty and cardiovascular health effects in lab animals, according to a new study spearheaded by researchers from North Carolina State University and Duke University.

25 Oct 2012

Northwestern scientists to request EPA to update guidelines for reproductive health research

A team of Northwestern University scientists will meet with Environmental Protection Agency (EPA) administrators in Washington D.C. Oct. 18 to advocate for important changes in the agency's guidelines for reproductive health research.

17 Oct 2012

Researchers identify critical mechanisms of epigenetic cell programming

A team of researchers at the IRCM, supervised by Dr. Jacques Drouin, reprogrammed the identity of cells in the pituitary gland and identified critical mechanisms of epigenetic cell programming.

17 Oct 2012

Resverlogix commences RVX-208 Phase 2 trial in pre-diabetes mellitus

Resverlogix Corp. today announced that it has initiated an exploratory Phase 2 clinical trial in patients with pre-diabetes mellitus to examine the effects of RVX-208 and ApoA-I production on glucose metabolism.

17 Oct 2012

Research roundup: Addressing disparities in cancer diagnosis time, Medicare open season awareness

Researchers tested the effectiveness of using patient navigation programs with women who have abnormal breast or cervical cancer screenings. These programs aim to facilitate treatment by such things as arranging financial support, transportation to appointments, child care or interpreter services.

13 Oct 2012

Protocol allows researchers to generate functional thyroid tissue from stem cells

The generation of functional thyroid tissue from stem cells could allow the treatment of patients, which suffer from thyroid hormone deficiency due to defective function, or abnormal development of the thyroid gland.

12 Oct 2012

Progress toward preventing initial and recurrent episodes of C. diff infection

Surgeons are making progress toward preventing initial and recurrent episodes of clostridium difficile colitis (C. difficile or C. diff), a vicious bacterial infection that is estimated to affect about 336,000 people each year, typically patients on antibiotics.

6 Oct 2012

Long-term education for patients may futher improve diabetes outcomes

Although there have been significant advances in the provision of diabetes education since 2000, further improvements are still needed, say researchers.

5 Oct 2012

Paper proposes novel mathematical models for injection of insulin in type 1 and 2 diabetes

Diabetes mellitus is a chronic disease in which individuals exhibit high levels of sugar in the blood, either due to insufficient production of insulin-the hormone that allows glucose to be absorbed by body cells-or the body's lack of response to insulin. Type 1 diabetes occurs due to loss or dysfunction of β-cells of the pancreas, the organ that produces insulin. Type 2 diabetes is caused by a defective glucose-insulin regulatory system.

5 Oct 2012

ADA, Wiley partner to publish latest book in ‘Practical Guide Series’

John Wiley & Sons, Inc., recently announced a collaboration with the American Dental Association (ADA) to publish the latest book in their "Practical Guide Series," The ADA Practical Guide to Patients with Medical Conditions.

4 Oct 2012

Prevalence of diabetic complications is race-specific

Diabetes is among the ten leading causes of death in both white and African American patients, but the prevalence of diabetic complications are race-specific, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

4 Oct 2012

BMI concerns raised for childhood stem cell transplantation survivors

Childhood survivors of hematologic malignancies treated with allogeneic hematopoietic stem cell transplantation should undergo long-term monitoring of their body mass index and lean body mass, US researchers recommend.

3 Oct 2012

Low vitamin D levels may increase death in African American and Caucasian older adults

Low levels of vitamin D and high levels of parathyroid hormone are associated with increased mortality in African American and Caucasian older adults, according to a new study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology and Metabolism (JCEM).

3 Oct 2012

Low serum levels of IGF-1 and IGFBP-3 associated with Alzheimer's in men

Low serum levels of insulin-like growth factor-1 (IGF-1) and insulin-like growth factor binding protein-3 (IGFBP-3) are associated with Alzheimer's Disease in men, but not women, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM).

3 Oct 2012

Study opens new door to more personalized treatment of advanced breast cancer

For the first time, researchers have conducted a large trial in which they tested the entire genome of individual breast cancers to help personalize treatment. They released their findings at the ESMO 2012 Congress of the European Society for Medical Oncology in Vienna.

1 Oct 2012

HR status defines two different subsets of HER2 positive cancers

Human epidermal growth factor (HER2) positive breast cancers are often treated with the same therapy regardless of hormone receptor status. New research published in BioMed Central's open access journal Breast Cancer Research shows that women whose HER2 positive cancer was also hormone (estrogen and progesterone) receptor (HR) negative had an increased risk of early death, and that their cancer was less likely to recur in bone than those whose cancer retained hormone sensitivity.

1 Oct 2012

Endocrine News and Research

MED1 plays a central role in mediating tamoxifen resistance in breast cancer

Researchers discover how tamoxifen-resistant breast-cancer cells grow and proliferate

Radiation therapy protocol deviations associated with increased risk of treatment failure and overall mortality

AstraZeneca commences FASLODEX Phase III study for hormone receptor-positive metastatic breast cancer

Study indicates that Firemaster 550 is an endocrine disruptor

Northwestern scientists to request EPA to update guidelines for reproductive health research

Researchers identify critical mechanisms of epigenetic cell programming

Resverlogix commences RVX-208 Phase 2 trial in pre-diabetes mellitus

Research roundup: Addressing disparities in cancer diagnosis time, Medicare open season awareness

Protocol allows researchers to generate functional thyroid tissue from stem cells

Progress toward preventing initial and recurrent episodes of C. diff infection

Long-term education for patients may futher improve diabetes outcomes

Paper proposes novel mathematical models for injection of insulin in type 1 and 2 diabetes

ADA, Wiley partner to publish latest book in ‘Practical Guide Series’

Prevalence of diabetic complications is race-specific

BMI concerns raised for childhood stem cell transplantation survivors

Low vitamin D levels may increase death in African American and Caucasian older adults

Low serum levels of IGF-1 and IGFBP-3 associated with Alzheimer's in men

Study opens new door to more personalized treatment of advanced breast cancer

HR status defines two different subsets of HER2 positive cancers

Industry Focus eBook - Neurology/Neuroscience - 2nd edition eBook

Improving healthcare sustainability through carbon data

Managing vibration in IVF laboratories

A New Approach to Preventing Bladder Cancer Recurrence

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