Malignant News and Research

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Johns Hopkins scientists discover earliest premalignant genetic changes that mark potential onset of lung cancer

Working with tissue, blood and DNA from six people with precancerous and cancerous lung lesions, a team of Johns Hopkins scientists has identified what it believes are among the very earliest “premalignant” genetic changes that mark the potential onset of the most common and deadliest form of disease.

23 Sep 2015

Researchers identify triple mechanism that prevents onset of chromosomal instability

Universitat Autònoma de Barcelona researchers have identified for the first time the triple mechanism that stops chromosome separation in response to situations that compromise the integrity of the genetic information. The loss of this response capacity is characteristic of cancerous cells.

18 Sep 2015

Gynaecological cancer still remains a taboo subject

They're thrown into menopause in their twenties, lose the possibility to have biological children, and struggle with their sex life.

18 Sep 2015

Using integrated molecular pathology to manage incidental pancreatic cysts: an interview with Dr Ananya Das

Pancreatic cystic neoplasms, or PCNs, are a subset of all pancreatic cysts that are found on the pancreas. PCNs are neoplastic cysts that span a biological spectrum from benign to malignant.

15 Sep 2015

Roflumilast drug could inhibit growth of brain tumor in children

Current drugs may stop working against the most common type of brain tumor in children, medulloblastoma, but the tumor could be targeted in a new way, according to Stanford University scientists.

15 Sep 2015

Researchers show how a cell surface protein can mobilize immune cells to attack malignant tumors

Revealing a biological combat strategy worthy of a five-star general, researchers from Houston Methodist Hospital, University of Chicago and Cornell University have shown how a cell surface receptor--a specialized protein which communicates signals between a cell and the outside world--can mobilize immune cells to attack, rather than protect, malignant tumors.

15 Sep 2015

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

Genetics researchers from Case Western Reserve School of Medicine have identified a novel long non-coding RNA (lncRNA), dubbed DACOR1, that has the potential to stymie the growth of tumor cells in the second-most deadly form of cancer in the U.S. — colorectal cancer.

14 Sep 2015

DelMar presents updated VAL-083 Phase I/II trial data at GBM2015 meeting

DelMar Pharmaceuticals, Inc., a biopharmaceutical company focused on the development and commercialization of new cancer therapies, today presented updated clinical data from its Phase I/II study of lead product candidate VAL-083 (dianhydrogalactitol), in patients with refractory glioblastoma multiforme (GBM), at GBM2015: 2nd International Symposium on Clinical and Basic Investigation in Glioblastoma in Toledo, Spain.

10 Sep 2015

New statistical model may help predict patients more likely to benefit from surgical treatment for mesothelioma

A new statistical model may help predict which patients are most likely to receive life-extending benefits from surgical treatment for malignant pleural mesothelioma (MPM), according to an article in the September 2015 issue of the Annals of Thoracic Surgery.

9 Sep 2015

UCSF researchers lead $10 million research project on pediatric cancer

Researchers at UC San Francisco are leading a five-year, $10 million research project dedicated to pediatric cancer, funded by the first grant of its kind to focus on a molecular pathway that underlies many cancers rather than on a cancer in a particular organ or tissue in the body.

9 Sep 2015

Common drug used for treating fungal infections in lung transplant recipients increases risk for skin cancer, death

Voriconazole, a prescription drug commonly used to treat fungal infections in lung transplant recipients, significantly increases the risk for skin cancer and even death, according to a new study by UC San Francisco researchers.

3 Sep 2015

Children's Hospital Los Angeles receives $2 million to spur research on brain, spinal cord tumors

A life-changing event for a Los Angeles family has resulted in their funding an endowment to support The Kort Family Foundation Brain and Spinal Cord Tumor Research Program in the Division of Neurosurgery at Children's Hospital Los Angeles.

3 Sep 2015

Treatment with life-saving medications increases in IHD but levels still suboptimal

Treatment with life-saving medications has increased over the past ten years in ischaemic heart disease but levels are still suboptimal, according to the first results of the Chronic Ischaemic Cardiovascular Disease (CICD) Pilot Registry presented today at ESC Congress 2015 and published in European Heart Journal.

2 Sep 2015

Altering protein recycling complexes in human cells may help overcome chemotherapy resistance

Altering the protein recycling complexes in human cells, including cancer cells, allows the cells to resist treatment with a class of drugs known as proteasome inhibitors, according to Whitehead Institute scientists.

2 Sep 2015

New statistical model may help predict patients most likely to benefits from surgical treatment for mesothelioma

1 Sep 2015

DAPT Study shows dual antiplatelet therapy reduces bleeding-related mortality

Fatal bleeding is rare with extended dual antiplatelet therapy, according to a secondary analysis of the DAPT Study presented for the first time today at ESC Congress. Bleeding-related mortality accounted for a minority of deaths in patients treated with dual antiplatelet therapy beyond one year.

1 Sep 2015

Carbonated beverage consumption associated with out-of-hospital cardiac arrests of cardiac origin

Carbonated beverages are associated with out-of-hospital cardiac arrests of cardiac origin, according to results from the All-Japan Utstein Registry presented for the first time today at ESC Congress.

1 Sep 2015

MACC1 gene can help predict better treatment options for patients with Klatskin carcinoma

Bile duct cancer is rare and is usually detected too late. Often only extensive liver surgery can help or, in rare cases, liver transplantation. But which patients will benefit from surgery and which will not, because their risk of cancer recurrence is too high? With the oncogene MACC1 as a biomarker, physicians for the first time have a tool to decide which treatment option is best for patients with Klatskin carcinoma, one type of bile duct cancer.

1 Sep 2015

After acute myocardial infarction, respiratory infection associated with increased risk of mortality

Respiratory infection is associated with a four-fold increased risk of in-hospital cardiovascular mortality after acute myocardial infarction (AMI), according to research presented at ESC Congress today by Dr Catarina Quina-Rodrigues, a cardiologist at Hospital de Braga in Portugal. The findings highlight the importance of diagnostic alertness for respiratory infections in AMI patients so that therapeutic measures can be promptly taken.

31 Aug 2015

Brain tumor is not always the death sentence

Only half of brain cancers actually start in the brain. The rest - as in the case of former president Jimmy Carter - are metastatic tumors from cancer that originated elsewhere in the body.

29 Aug 2015

Malignant News and Research

Johns Hopkins scientists discover earliest premalignant genetic changes that mark potential onset of lung cancer

Researchers identify triple mechanism that prevents onset of chromosomal instability

Gynaecological cancer still remains a taboo subject

Using integrated molecular pathology to manage incidental pancreatic cysts: an interview with Dr Ananya Das

Roflumilast drug could inhibit growth of brain tumor in children

Researchers show how a cell surface protein can mobilize immune cells to attack malignant tumors

Novel long non-coding RNA has potential to stymie growth of tumor cells in colon cancer

DelMar presents updated VAL-083 Phase I/II trial data at GBM2015 meeting

New statistical model may help predict patients more likely to benefit from surgical treatment for mesothelioma

UCSF researchers lead $10 million research project on pediatric cancer

Common drug used for treating fungal infections in lung transplant recipients increases risk for skin cancer, death

Children's Hospital Los Angeles receives $2 million to spur research on brain, spinal cord tumors

Treatment with life-saving medications increases in IHD but levels still suboptimal

Altering protein recycling complexes in human cells may help overcome chemotherapy resistance

New statistical model may help predict patients most likely to benefits from surgical treatment for mesothelioma

DAPT Study shows dual antiplatelet therapy reduces bleeding-related mortality

Carbonated beverage consumption associated with out-of-hospital cardiac arrests of cardiac origin

MACC1 gene can help predict better treatment options for patients with Klatskin carcinoma

After acute myocardial infarction, respiratory infection associated with increased risk of mortality

Brain tumor is not always the death sentence

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

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