Malignant News and Research

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Mayo Clinic study highlights LumaGEM MBI as cost-effective tool for detecting women with dense breast tissue

A recent study conducted by Mayo Clinic has determined that the addition of Molecular Breast Imaging (MBI) for women with dense breast tissue resulted in a lower cost per cancer detected than screening with mammography alone.

17 Aug 2015

Unituxin (dinutuximab) granted EC Marketing Authorisation for treatment of childhood neuroblastoma

United Therapeutics Corporation announced today that the European Commission (EC) has granted Marketing Authorisation for Unituxin (dinutuximab) for the treatment of high-risk neuroblastoma in patients aged 12 months to 17 years, who have previously received induction chemotherapy and achieved at least a partial response, followed by myeloablative therapy and autologous stem cell transplantation (ASCT).

17 Aug 2015

Researchers use advanced photodynamic therapy to combat ovarian cancer in laboratory animals

Researchers at Oregon State University have made a significant advance in the use of photodynamic therapy to combat ovarian cancer in laboratory animals, using a combination of techniques that achieved complete cancer cell elimination with no regrowth of tumors.

14 Aug 2015

New endoscopic system differentiates between malignant and benign tumors in gastrointestinal tract

Cancer or no cancer? This question can usually only be answered after a days-long wait for a histological examination. With the use of a mass spectrometric technique, the answer may soon be available in real time.

13 Aug 2015

New research could help develop precision medicine for primary aldosteronism

Each of your kidneys wears a little yellow cap that helps keep your blood pressure in check, and much more. But in some people, it starts running amok, pumping out a hormone that sends blood pressure sky-high.

13 Aug 2015

Risk of hepatobiliary cancer higher in women with intrahepatic cholestasis of pregnancy

In a new study of more than 125,000 pregnant women in Sweden, researchers at the Sahlgrenska Academy found that the risk of hepatobiliary cancer and immune-mediated and cardiovascular diseases later in life is higher in women with intrahepatic cholestasis of pregnancy (ICP) than in women without this condition.

12 Aug 2015

New review points to most promising areas for liposomes' further development

An international group of scientists, including Vladimir Chupin, head of the Biophysics Section at MIPT, and Vladimir Torchilin (Northeastern University, the USA), one of the world's leading experts in pharmacology, recently presented a review of liposomes, microscopic capsules widely used all over the world in the development of new drugs.

11 Aug 2015

Study reveals that miR-7 suppresses gastric cancer by inhibiting key signaling pathway

A study in The Journal of Cell Biology reveals that the microRNA miR-7 suppresses gastric (stomach) cancer by inhibiting a key signaling pathway, and that this protective mechanism is compromised by the cancer-causing bacterium H. pylori. Finding drugs capable of inducing miR-7 could therefore prove to be an effective treatment against the progression of gastric cancer.

11 Aug 2015

Investigational topical drug shows promise in patients with early stage cutaneous T cell lymphoma

Results of a phase one trial show that an investigational topical drug, resiquimod gel, causes regression of both treated and untreated tumor lesions and may completely remove cancerous cells from both sites in patients with early stage cutaneous T cell lymphoma (CTCL) - a rare type of non-Hodgkin lymphoma that affects the skin.

7 Aug 2015

Scientists develop biosensor to measure abnormal activity of cell 'fuel' carrier

To be able to function, cell mitochondria import "fuel" using a carrier, the Mitochondrial Pyruvate Carrier (MPC). In order to determine whether the MPC is still functional in malignant cells, the team of Professor Jean-Claude Martinou, at the University of Geneva, Switzerland, has just developed a biosensor to measure its live activity.

7 Aug 2015

Hedgehog blockade promising in myeloid malignancies

Phase I trial results published in The Lancet Haematology show that the hedgehog signalling pathway antagonist PF-04449913 is tolerable and has activity in patients with haematological cancers.

5 Aug 2015

New Tel Aviv University study sheds light on precise trigger of deadly melanoma

Skin cancer is the most common of all cancers, and melanoma, which accounts for 2% of skin cancer cases, is responsible for nearly all skin cancer deaths. Melanoma rates in the US have been rising rapidly over the last 30 years, and although scientists have managed to identify key risk factors, melanoma's modus operandi has eluded the world of medical research.

4 Aug 2015

Scientists successfully test new tumor diagnosis method

Scientists at the Helmholtz-Zentrum Dresden-Rossendorf, in cooperation with colleagues at the University of Zurich and the Ruhr-Universität Bochum, have for the first time successfully tested a new tumor diagnosis method under near-real conditions. The new method first sends out an antibody as a "spy" to detect the diseased cells and then binds to them.

4 Aug 2015

Combining chemotherapy and birinapant effective against high-grade serous ovarian cancer

High-grade serous ovarian cancer often responds well to the chemotherapy drug carboplatin, but why it so frequently comes back after treatment has been a medical mystery.

4 Aug 2015

Array Biopharma reports strong fourth quarter and full year 2015 financial results

Array BioPharma Inc. today reported results for the fourth quarter and full year of its fiscal year ended June 30, 2015.

3 Aug 2015

High levels of specific proteins in urine can accurately detect early-stage pancreatic cancer

A combination of three proteins found at high levels in urine can accurately detect early-stage pancreatic cancer, UK researchers have found.

3 Aug 2015

Intraoperative fluorescent imaging detects lung adenocarcinoma during pulmonary resection

More than 80,000 people undergo resection of a pulmonary tumor each year, and currently the only method to determine if the tumor is malignant is histologic analysis. A new study reports that a targeted molecular contrast agent can be used successfully to cause lung adenocarcinomas to fluoresce during pulmonary surgery.

30 Jul 2015

Vismodegib therapy effective against medulloblastoma

A targeted therapy already used to treat advanced skin cancer is also effective against the most common subtype of the brain tumor medulloblastoma in adults and should be considered for treatment of newly diagnosed patients, according to research led by St. Jude Children's Research Hospital.

30 Jul 2015

LMU researchers reveal role of mutations in development of Ewing's sarcoma

Researchers from Ludwig-Maximilians-Universitaet in Munich have elucidated at the molecular level how an otherwise innocuous inherited mutation that is quite common in European populations interacts with a spontaneous somatic mutation to promote the development of Ewing's sarcoma.

28 Jul 2015

New technique improves survival time for glioblastoma patients by 50%

The rapid spread of a common and deadly brain tumor has been slowed down significantly in a mouse model by cutting off the way some cancer cells communicate, according to a team of researchers that includes UF Health faculty.

28 Jul 2015

Malignant News and Research

Mayo Clinic study highlights LumaGEM MBI as cost-effective tool for detecting women with dense breast tissue

Unituxin (dinutuximab) granted EC Marketing Authorisation for treatment of childhood neuroblastoma

Researchers use advanced photodynamic therapy to combat ovarian cancer in laboratory animals

New endoscopic system differentiates between malignant and benign tumors in gastrointestinal tract

New research could help develop precision medicine for primary aldosteronism

Risk of hepatobiliary cancer higher in women with intrahepatic cholestasis of pregnancy

New review points to most promising areas for liposomes' further development

Study reveals that miR-7 suppresses gastric cancer by inhibiting key signaling pathway

Investigational topical drug shows promise in patients with early stage cutaneous T cell lymphoma

Scientists develop biosensor to measure abnormal activity of cell 'fuel' carrier

Hedgehog blockade promising in myeloid malignancies

New Tel Aviv University study sheds light on precise trigger of deadly melanoma

Scientists successfully test new tumor diagnosis method

Combining chemotherapy and birinapant effective against high-grade serous ovarian cancer

Array Biopharma reports strong fourth quarter and full year 2015 financial results

High levels of specific proteins in urine can accurately detect early-stage pancreatic cancer

Intraoperative fluorescent imaging detects lung adenocarcinoma during pulmonary resection

Vismodegib therapy effective against medulloblastoma

LMU researchers reveal role of mutations in development of Ewing's sarcoma

New technique improves survival time for glioblastoma patients by 50%

Advancing Intracellular Delivery with LumiPore®

How ELRIG Is Helping Mid-Career Scientists Navigate Leadership, Career Change and Redundancy

The role of UV-Vis in biopharma QC

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