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Vascular targeted nanoparticles for imaging and treatment of brain tumors

Combining two promising approaches to diagnosing and treating cancer, a multidisciplinary research team at the University of Michigan has created a targeted multifunctional polymer nanoparticle that successfully images and kills brain tumors in laboratory animals.

4 Dec 2006

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

Waiting a day or more to get lab results back from the doctor's office soon could become a thing of a past.

4 Dec 2006

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

In attempt to identify biological markers, or biomarkers, that can signal the presence of cancer and help oncologists determine the best course of therapy when cancer is present, teams of investigators are scouring stored tissue samples obtained from thousands of cancer patients.

4 Dec 2006

Nonlithographic fabrication of microfluidic devices

Typically, researchers create microfluidic devices using the same lithographic techniques and tools used to fabricate computer chips. Lithography is expensive and slow, factors that could limit the ultimate utility of microfluidic devices in clinical applications.

4 Dec 2006

Nanotechnology continues to advance anticancer gene therapy

Given that cancer is a disease in which genetic errors play a major role, it should come as no surprise that many experts envision a time when gene therapy will play an equally important role in the treatment of cancer.

20 Nov 2006

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Whether the goal is to separate different types of cells or molecules, methods that rely on the age-old principle of magnetism are a staple among researchers.

20 Nov 2006

Watching a tumor cell migrate

Using a microfluidics device designed to reproduce the physical microenvironment of small blood vessels and the spaces between cells, researchers at the National University of Singapore have imaged single tumor cells deforming as they migrate through the device.

20 Nov 2006

Templated self-assembly of quantum dots from aqueous solution using protein scaffolds

Quantum dots are rapidly becoming biomedical researchers' tool of choice for adding a fluorescent label to a wide variety of biomolecules.

20 Nov 2006

International plan to protect against counterfeit medicines

The World Health Organization (WHO) and more than 20 international partners are today launching a comprehensive package of measures to help national authorities safeguard their populations from the dangers of counterfeit medicines.

15 Nov 2006

Optical amplification of photothermal therapy with gold nanoparticles and nanoclusters

Gold nanoparticles, through their unique ability to convert light into heat, show great promise as miniature heaters capable of cooking cancer cells to death.

13 Nov 2006

Modified silicon-based surfaces provide good home to proteins

Silicon, whether in its elemental form as silicon wafers or in its oxidized form, known as silicon dioxide or silica, is proving to be a valuable material for biomedical nanotechnology, in large part because of the biocompatibility and chemical inertness of these substances.

13 Nov 2006

Polymer coating improves tumor-targeting nanoparticles

Adding a thin coating of the biocompatible polymer poly(ethylene glycol) (PEG) to the surface of sulfur-modified, or thiolated, nanoparticles designed to fall apart inside tumors, prolongs the time that the resulting nanoparticles remain in tumors.

13 Nov 2006

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

In a dramatic demonstration of the power of nanotechnology, a team of investigators has designed a nanoscale, polymeric drug delivery vehicle that when loaded with a widely used anticancer agent cures colon cancer in mice with a single dose.

13 Nov 2006

NIH is solicits suggestions for new initiatives under the aegis of the NIH Roadmap

The NIH is actively soliciting suggestions for new initiatives to be implemented under the aegis of the NIH Roadmap. The NIH intends to spend $30-50 million/year from within the currently projected Roadmap budget for approximately 5-8 new initiatives, beginning in FY2008.

6 Nov 2006

MRI technology breaks new ground in molecular imaging

Researchers with the U.S. Department of Energy's Lawrence Berkeley National Laboratory and the University of California at Berkeley have developed a new technique for magnetic resonance imaging (MRI) that allows for detection of signals from molecules present at 10,000 times lower concentrations than conventional MRI techniques.

6 Nov 2006

Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting

Cancer biologists are always on the lookout for new methods of studying the effects that drug therapy has on malignant cells.

6 Nov 2006

Nanoparticles for two-photon photodynamic therapy in living cells

Photodynamic therapy (PDT) uses a combination of ultraviolet or visible light and a light-sensitive chemical, or photosensitizer, to kill cancer cells using reactive oxygen.

6 Nov 2006

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

In an attempt to create a single device that can image and treat tumors simultaneously, researchers at the University of Texas Southwestern Medical Center at Dallas have successfully melded magnetic iron nanoparticles, the anticancer drug doxorubicin, and a polymer tagged with a tumor-targeted molecule into a stable nanoparticle that accumulates inside human tumor cells.

6 Nov 2006

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

Though researchers have made substantial progress in developing drug-ferrying nanoparticles that successfully target tumor cells in living animals, including humans, investigators have only now started the detailed work needed to identify formulation parameters that would optimize drug delivery to malignant cells.

6 Nov 2006

Lab-on-a-chip nanoscale array monitors cellular processes

Researchers at Tel-Aviv University in Israel have developed a lab-on-a-chip device that can incorporate enzymes and even living cells in a nanoscale array capable of monitoring electrochemical reactions.

30 Oct 2006

Nanotechnology News and Research

Vascular targeted nanoparticles for imaging and treatment of brain tumors

Biofunctional organic nanocrystals for quantitative detection of pathogen deoxyribonucleic acid

High throughput quantification of protein expression of cancer antigens in tissue microarray using quantum dot nanocrystals

Nonlithographic fabrication of microfluidic devices

Nanotechnology continues to advance anticancer gene therapy

Low-field magnetic separation of monodisperse Fe3O4 nanocrystals

Watching a tumor cell migrate

Templated self-assembly of quantum dots from aqueous solution using protein scaffolds

International plan to protect against counterfeit medicines

Optical amplification of photothermal therapy with gold nanoparticles and nanoclusters

Modified silicon-based surfaces provide good home to proteins

Polymer coating improves tumor-targeting nanoparticles

A single dose of doxorubicin-functionalized bow-tie dendrimer cures mice bearing C-26 colon carcinomas

NIH is solicits suggestions for new initiatives under the aegis of the NIH Roadmap

MRI technology breaks new ground in molecular imaging

Nanoparticle probes with surface enhanced Raman spectroscopic tags for cellular cancer targeting

Nanoparticles for two-photon photodynamic therapy in living cells

Multifunctional polymeric micelles as cancer-targeted, MRI-ultrasensitive drug delivery systems

Formulation of functionalized PLGA-PEG nanoparticles for in vivo targeted drug delivery

Lab-on-a-chip nanoscale array monitors cellular processes

Sensing a Healthier Future

Achieving and maintaining ISO/IEC 27001 and BS 10012 certifications

Expanding research and clinical options for children with cancer

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