Research News and Research

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Abraxane, first in a new class of albumin-bound nanotechnology for the treatment of metastatic breast cancer

Abraxane (paclitaxel protein-bound particles for injectable suspension), a next generation taxane, and the first in a new class of albumin-bound nanotechnology, was approved for the treatment of metastatic breast cancer.

9 Jan 2005

How consumers process negative food messages

No saturated fat. Less filling. No MSG added. No trans fats. No sugar added… Called negations, advertising messages that contain terms like 'not' or 'no' are meant to highlight some distinctive characteristic about the product being sold.

9 Jan 2005

Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Scientists in Brown Medical School, Providence, USA, have found that core promoter mutants of Hepatitis B Virus e Antigen replicate at up to 10-fold higher levels in transfected human hepatoma cells than the wild-type virus.

9 Jan 2005

Pegylated interferon alfa-2b offers the best treatment option for people with chronic hepatitis B infection

Harry Janssen (Erasmus University Medical Centre, Rotterdam, Netherlands) and colleagues assessed whether combination treatment with pegylated interferon alfa-2b and the antiviral agent lamivudine was more efficacious in treating chronic hepatitis B infection than pegylated interferon alfa-2b therapy alone.

7 Jan 2005

Diagnosis of tuberculosis in young children can be confirmed by a straightforward sputum test

Diagnosis of tuberculosis is difficult in infants and young children and can be complicated by HIV infection. Heather Zar (School of Child and Adolescent Health, University of Cape Town, South Africa) and colleagues studied 250 children aged 1 month to 5 years who were admitted for suspected pulmonary tuberculosis in Cape Town. Sputum induction and gastric lavage were done on three consecutive days according to a standard procedure.

7 Jan 2005

Promising new evidence for the optimal use of biologic therapies for rheumatoid arthritis

A major cause of pain and disability, rheumatoid arthritis (RA) is also potentially the most treatable form of chronic arthritis. Researchers, doctors, and patients agree that a group of drugs called disease-modifying antirheumatic drugs (DMARDs) can effectively reduce joint pain and stiffness.

7 Jan 2005

Strong association between high levels of hyaluronic acid and severe osteoarthritis

A chronic degenerative joint disease, osteoarthritis (OA) is a common cause of pain and disability among older Americans. OA of the knee affects up to 6 percent of the older population, while OA of the hip affects about another 3 percent. While treatments vary, there is hope that early intervention – before joint destruction can be clearly seen and measured on an X-ray image-will improve outcomes.

7 Jan 2005

Fallout from Vioxx and Celebrex market recall challenges industry

The pharmaceutical and biotechnology industries face further marketing and sales challenges in 2005 as the fallout from the Vioxx and Celebrex market recall and warning make it increasingly challenging for companies across the industry to reach physicians and consumers with effective campaigns without the distractions of the unfavorable press these recent events have generated.

7 Jan 2005

Injuries and deaths caused by unexploded ordnance in Afghanistan

Unexploded military material in Afghanistan cause more injuries and deaths than landmines especially among children, according to research published on bmj.com today.

7 Jan 2005

Financial barriers to a career in medicine are growing

The financial barriers to a career in medicine are growing, the BMA says today (Friday 7 January 2005), as new figures show the average fifth year medical student is in debt by £19,248 - 16% higher than last year - and many owe more than £30,000.

7 Jan 2005

First program to apply RNA interference (RNAi) technology to asthma

Sirna Therapeutics, Inc. has announced the first program to apply RNA interference (RNAi) technology to asthma, a highly prevalent, chronic disease accounting for an estimated $13 billion in healthcare costs in the United States, a number which is forecast to grow considerably by the end of the decade.

7 Jan 2005

New guidelines for treating diabetes

Every year, the American Diabetes Association (ADA) issues Clinical Practice Recommendations, a series of updated recommendations to help health care providers treat people with diabetes using the most current research available.

7 Jan 2005

New form of treatment for cancer of the larynx

Surgeons at Montefiore Medical Center are using a new form of treatment for cancer of the larynx that allows for quicker recovery and shorter hospital stays, and saves the voice box so patients retain the ability to speak.

7 Jan 2005

Peginterferon alfa-2b produced sustained responses in patients with chronic hepatitis B

Results from a large international clinical study reported in this week's issue of The Lancet showed that peginterferon alfa-2b produced sustained responses in patients with chronic hepatitis B. The investigator-initiated study is the largest clinical trial to date with peginterferon alfa-2b therapy for chronic hepatitis B.

7 Jan 2005

Now significantly easier to search long stretches of DNA for genetic changes associated with disease

The researchers developed a method called direct genomic selection that accelerates the transition between family or population-based studies of disease inheritance patterns and identification of genetic variations that may contribute to disease.

6 Jan 2005

Protein discovery with medical implications

It was a transforming moment. Researchers could barely believe their eyes. A molecular blob of a protein reshaped itself into a molecular Pacman in order to free new viruses from the inside of a bacterial cell.

6 Jan 2005

Discovery could lead to a screening test that identifies people who have a higher or lower susceptibility to HIV/AIDS

People with more copies of a gene that helps to fight HIV are less likely to become infected with the virus or to develop AIDS than those of the same geographical ancestry, such as European Americans, who have fewer copies of the gene, according to a study funded by the National Institute of Allergy and Infectious Diseases (NIAID).

6 Jan 2005

Single abnormal cell can duplicate to form cancerous tumors

Researchers at the University of Pittsburgh have identified how a single aberrant cell can duplicate to form cancerous tumors, suggesting a specific protein mechanism as a target for the treatment of cancer, they report in a paper titled "Spindle Multipolarity Is Prevented by Centrosomal Clustering," published in the Jan. 7 issue of Science.

6 Jan 2005

Adults with pre-diabetes can lose up to 3 percent of their body weight using diet

Adults with pre-diabetes can lose up to 3 percent of their body weight using diet, exercise and behavioral strategies, according to a systematic review of studies that analyzed weight-loss strategies for pre-diabetics.

6 Jan 2005

Mutated gene may provide better idea of how cancer develops and progresses

Scientists are taking the first steps to find out how a gene that is mutated in many cancer cells functions in healthy cells.

6 Jan 2005

Research News and Research

Abraxane, first in a new class of albumin-bound nanotechnology for the treatment of metastatic breast cancer

How consumers process negative food messages

Core promoter mutants of Hepatitis B Virus e Antigen associated with development of fulminant hepatitis and liver cancer

Pegylated interferon alfa-2b offers the best treatment option for people with chronic hepatitis B infection

Diagnosis of tuberculosis in young children can be confirmed by a straightforward sputum test

Promising new evidence for the optimal use of biologic therapies for rheumatoid arthritis

Strong association between high levels of hyaluronic acid and severe osteoarthritis

Fallout from Vioxx and Celebrex market recall challenges industry

Injuries and deaths caused by unexploded ordnance in Afghanistan

Financial barriers to a career in medicine are growing

First program to apply RNA interference (RNAi) technology to asthma

New guidelines for treating diabetes

New form of treatment for cancer of the larynx

Peginterferon alfa-2b produced sustained responses in patients with chronic hepatitis B

Now significantly easier to search long stretches of DNA for genetic changes associated with disease

Protein discovery with medical implications

Discovery could lead to a screening test that identifies people who have a higher or lower susceptibility to HIV/AIDS

Single abnormal cell can duplicate to form cancerous tumors

Adults with pre-diabetes can lose up to 3 percent of their body weight using diet

Mutated gene may provide better idea of how cancer develops and progresses

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