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Mice studies reveal new insights into neurons that cause symptoms of Rett syndrome

Two studies in mice from Baylor College of Medicine, Texas, reveal new insights into neurons that mediate symptoms typical of the postnatal neurological disorder Rett syndrome.

29 Jun 2016

Bioengineers develop 2-in-1 nanomedicine for treating cancer

For cancer therapy, treatment resistance poses a major hurdle. Even aggressive treatments such as immunotherapies or nanomedicines may fail to eliminate all cancer cells, allowing new mutations to develop that may cause relapse.

28 Jun 2016

Epclusa drug receives FDA approval for treating adult patients with chronic HCV

The U.S. Food and Drug Administration approved Epclusa to treat adult patients with chronic hepatitis C virus (HCV) both with and without cirrhosis (advanced liver disease).

28 Jun 2016

Researchers find new way for treating GBS infection in neonates

Researchers have discovered how the bacteria Group B streptococcus (GBS) avoids detection by the immune system during pregnancy.

28 Jun 2016

Study examines role of HOX genes in ovarian cancer resistance

A new UK study has identified a gene signature that predicts poor survival from ovarian cancer. The study also identified genes which help the cancer develop resistance to chemotherapy - offering a new route to help tackle the disease.

28 Jun 2016

Scientists develop novel bionic cardiac patch to treat heart problems

Scientists and doctors in recent decades have made vast leaps in the treatment of cardiac problems - particularly with the development in recent years of so-called "cardiac patches," swaths of engineered heart tissue that can replace heart muscle damaged during a heart attack.

28 Jun 2016

Experimental lipid-lowering drug improves glucose control in diabetic patients

High triglycerides -- a type of fat, or lipid, in the blood -- increase the risk of heart disease and perhaps type 2 diabetes. For the first time, it has been shown that profoundly lowering triglycerides in diabetics improves their insulin sensitivity over time, which helps them maintain healthy glucose - blood sugar -- levels.

28 Jun 2016

Deficiency in NMD could cause inflammatory myofibroblastic tumors

Inflammatory myofibroblastic tumors (IMTs) — masses of immune cells— are benign, but poorly understood. Current IMT treatments often have side effects and surgery is sometimes not an option due to the tumor's proximity to vital organs.

28 Jun 2016

Blocking c-Abl enzyme prevents Parkinson’s disease progression in mice

Researchers at Johns Hopkins say they have gleaned two important new clues in the fight against Parkinson's disease: that blocking an enzyme called c-Abl prevents the disease in specially bred mice, and that a chemical tag on a second protein may signal the disorder's presence and progression.

28 Jun 2016

'Novel' analysis addresses antiplatelet benefits in real-world CHD patients

Researchers demonstrate a means of gauging the effects of drugs tested in randomised trials in real-world patients.

28 Jun 2016

Jefferson researchers discover alternate pathway that helps heart keep pumping

About 5.7 million Americans have heart failure, half of whom will die from the disease within 5 years, according to the Centers for Disease Control and Prevention.

28 Jun 2016

Why does appetite loss occur during illness? An interview with Prof. Conti and Prof. Francesconi

Appetite, as a word, come from the Latin appetitus, meaning "desire for.” Therefore, appetite can be defined as a pleasurable sensation or the desire to eat. This sensation is coordinated by several brain areas associated with reward processing such amygdala, hippocampus, ventral pallidum, nucleus accumbens and striatum, and others.

28 Jun 2016

Study offers array of new insights into nature of Plasmodium vivax

A team of scientists has uncovered the global, evolving, and historic make-up of Plasmodium vivax, one of the five species of malaria that infect humans.

28 Jun 2016

Scientists explain how engineered anthrax toxin proteins could help eliminate cancerous tumors

Scientists from the National Institute of Allergy and Infectious Diseases, the National Institute of Dental and Craniofacial Research, and the National Heart, Lung and Blood Institute all parts of the National Institutes of Health, describe how combining engineered anthrax toxin proteins and existing chemotherapy drugs could potentially yield a therapy to reduce or eliminate cancerous tumors.

28 Jun 2016

Cisplatin-based chemotherapy may lead to hearing loss in many testicular cancer survivors

Many testicular cancer survivors experience hearing loss after cisplatin-based chemotherapy, according to researchers at Indiana University.

28 Jun 2016

Genomic techniques help scientists understand diversity of P.vivax parasites

While most malaria research has focused on the parasite Plasmodium falciparum, which is common in Africa, another parasite, Plasmodium vivax (P.vivax) is responsible for the majority of malaria infections outside this region, causing an estimated 15.8 million clinical malaria cases each year.

28 Jun 2016

New computer model shows how spleen filters misshapen red blood cells

Researchers, led by Carnegie Mellon University President Subra Suresh and MIT Principal Research Scientist Ming Dao, have created a new computer model that shows how tiny slits in the spleen prevent old, diseased or misshapen red blood cells from re-entering the bloodstream.

28 Jun 2016

Novel suite of computer algorithms can accurately predict behavior of gut microbiome

A team of investigators from Brigham and Women's Hospital and the University of Massachusetts have developed a suite of computer algorithms that can accurately predict the behavior of the microbiome - the vast collection of microbes living on and inside the human body.

28 Jun 2016

Anthrax capsule vaccine offers protection from deadly anthrax infection in monkeys

Vaccination with the anthrax capsule--a naturally occurring component of the bacterium that causes the disease--completely protected monkeys from lethal anthrax infection, according to a study published online this week in the journal VACCINE.

27 Jun 2016

HDAC inhibitors may help regulate alcoholism-induced anxiety

Epigenetics is the study of changes in organisms caused by modifying gene expression - by alcohol, for example - rather than alteration of the genetic code itself. Recent evidence suggests that alcohol can inhibit activity of an enzyme called histone deacetylase (HDAC) in the amygdala, a brain region that is crucial for storing memories and regulating fear, anxiety, and other emotions.

27 Jun 2016