Protein News and Research

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Proteins are complex molecules that are made up of amino acids. They can be found in every cell in the body, and carry out vital processes that keep human beings alive. Mutations in proteins can lead to a multitude of diseases, the most common being cancer.

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

AstraZeneca and Merck, known as MSD outside the United States and Canada, today announced that Japan's Pharmaceuticals and Medical Devices Agency has approved LYNPARZA tablets for use in patients with unresectable or recurrent BRCA-mutated, human epidermal growth factor receptor 2 -negative breast cancer who have received prior chemotherapy.

2 Jul 2018

Ocular Therapeutix resubmits NDA for DEXTENZA

Ocular Therapeutix™, Inc., a biopharmaceutical company focused on the formulation, development, and commercialization of innovative therapies for diseases and conditions of the eye, has announced the resubmission of the Company's New Drug Application to the U.S. Food and Drug Administration for its lead product candidate DEXTENZA™ 0.4mg, for the treatment of ocular pain following ophthalmic surgery.

30 Jun 2018

Study finds that several existing anti-cancer drugs may work in part by binding to RNA

Bolstering the notion that RNA should be considered an important drug-discovery target, scientists at Scripps Research have found that several existing, FDA-approved anti-cancer drugs may work, in part, by binding tightly to RNA, the regulators of the basic activities of life within cells.

30 Jun 2018

KU Cancer Center launches clinical trial to eliminate radiation therapy for HER2-positive breast cancer

Researchers at The University of Kansas Cancer Center have launched a clinical trial that eliminates radiation from the treatment protocol for an invasive type of breast cancer that accounts for one-fifth of all breast cancer patients.

30 Jun 2018

Timing may be key to evading destruction for bacteria facing antibiotics

For bacteria facing a dose of antibiotics, timing might be the key to evading destruction. In a series of experiments, Princeton researchers found that cells that repaired DNA damaged by antibiotics before resuming growth had a much better chance of surviving treatment.

30 Jun 2018

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

The California Institute for Regenerative Medicine board has awarded City of Hope $3.7 million to develop a phase 1 clinical trial for glioblastoma patients that will genetically engineer their stem cells to better tolerate chemotherapy's side effects, allowing them to receive higher doses of the therapy.

30 Jun 2018

Research shows why new cancer therapies fail to work on some patients

University of Otago research provides insights into an underlying mechanism that could explain why new cancer therapies to help treat metastatic melanoma do not always work on patients, paving the way for predicting which patients will benefit from certain drugs.

30 Jun 2018

Tau protein allows microtubules to grow and remain dynamic, shows study

A new study by researchers from Drexel University College of Medicine reverses the popular scientific dogma that the protein tau stabilizes microtubules within brain cells.

30 Jun 2018

Scientists focus on critical regulatory protein to find clues on cancer, neurodegenerative diseases

James McNew's and Michael Stern's biochemical hunt for the root cause of a rare, paralyzing genetic disorder is a 10-year quest that's taken an unexpected turn toward everyday killers such as Alzheimer's disease, cancer and aging.

30 Jun 2018

Enzyme TLK2 could serve as potential therapies for breast cancer, brain condition

In recent years, researchers have focussed on the enzyme TLK2 suspecting it of playing a main role in several diseases.

30 Jun 2018

Scientists discover how the flu virus resets its trap

For the first time, scientists have directly visualized in real-time structural changes in the surface protein of the influenza virus that may help the virus to fuse with and enter target cells before hijacking their functions.

29 Jun 2018

Modified natural killer cells may be new player in CAR-T immunotherapies

Emerging CAR-T immunotherapies leverage modified versions of patient's T-cells to target and kill cancer cells.

29 Jun 2018

Scientists provide clear picture of mysterious component of the inner ear

A few years ago, Ian Swinburne, HMS research fellow in systems biology, noticed something odd while conducting a time-lapse microscopy study of the inner ear of zebrafish. A tiny structure in the inner ear was pulsing like clockwork, inflating and deflating over and over.

29 Jun 2018

New mouse model could shed light on autism subtype

Researchers at the UC Davis MIND Institute have created a mouse model for maternal antibody- related (MAR) autism spectrum disorder that closely mimics the physiology and behaviors seen in people with this form of ASD.

29 Jun 2018

Human leukemia virus increases disease risk by changing the way DNA loops inside our cells

A human virus that causes a rare form of leukemia increases the risk of disease by changing the way DNA loops inside our cells.

29 Jun 2018

Researchers discover way to reverse drug resistance in some skin and mouth cancers

University of Queensland researchers have discovered how to reverse drug resistance in skin and mouth squamous cell carcinomas.

29 Jun 2018

Children's Colorado participates in cystic fibrosis triple combination therapy trials

Children's Hospital Colorado has announced that its Mike McMorris Cystic Fibrosis Research and Care Center, one of the largest cystic fibrosis clinical care centers in the U.S., is participating in one of two Phase Three clinical trials related to the development of a possible breakthrough therapy for people with CF.

29 Jun 2018

Hearing partially restored in deaf lab mice using novel therapy

A small molecule of a drug has been successfully used to treat an inherited form of hearing loss in laboratory mice.

28 Jun 2018

Molecular brake on cell proliferation prevents DNA damage and cancer development

Researchers at Karolinska Institutet, Sweden, and the University of Sussex, England, have discovered that the process of copying DNA generates a brake signal that stalls cell division.

28 Jun 2018

Study shows precision medicine improves outcomes in pancreatic cancer patients

A study published today by the Pancreatic Cancer Action Network, Perthera, Inc., and colleagues in the AACR journal Clinical Cancer Research found for the first time that precision medicine can improve outcomes and provide clinically meaningful information to pancreatic cancer patients.

28 Jun 2018

Protein News and Research

Further Reading

PMDA approves use of LYNPARZA in patients with BRCA-mutated breast cancer

Ocular Therapeutix resubmits NDA for DEXTENZA

Study finds that several existing anti-cancer drugs may work in part by binding to RNA

KU Cancer Center launches clinical trial to eliminate radiation therapy for HER2-positive breast cancer

Timing may be key to evading destruction for bacteria facing antibiotics

City of Hope receives $3.7 million from CIRM to develop phase 1 glioblastoma trial

Research shows why new cancer therapies fail to work on some patients

Tau protein allows microtubules to grow and remain dynamic, shows study

Scientists focus on critical regulatory protein to find clues on cancer, neurodegenerative diseases

Enzyme TLK2 could serve as potential therapies for breast cancer, brain condition

Scientists discover how the flu virus resets its trap

Modified natural killer cells may be new player in CAR-T immunotherapies

Scientists provide clear picture of mysterious component of the inner ear

New mouse model could shed light on autism subtype

Human leukemia virus increases disease risk by changing the way DNA loops inside our cells

Researchers discover way to reverse drug resistance in some skin and mouth cancers

Children's Colorado participates in cystic fibrosis triple combination therapy trials

Hearing partially restored in deaf lab mice using novel therapy

Molecular brake on cell proliferation prevents DNA damage and cancer development

Study shows precision medicine improves outcomes in pancreatic cancer patients

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