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Women suffering from blood clots can safely take hormone replacement therapy with anticoagulants

New research published online today in Blood, the Journal of the American Society of Hematology (ASH), is the first to demonstrate that women on blood thinners can take estrogen-containing contraception or hormone replacement therapy without an increased risk of blood clots or uterine bleeding.

23 Dec 2015

Baxalta announces initial results from ADYNOVATE Phase 3 trial for treatment of hemophilia patients

Baxalta Incorporated, a global biopharmaceutical leader dedicated to delivering transformative therapies to patients with orphan diseases and underserved conditions, today announced initial results from a Phase 3 clinical trial of ADYNOVATE [Antihemophilic Factor (Recombinant), PEGylated], an extended circulating half-life recombinant Factor VIII (rFVIII) treatment for hemophilia A based on ADVATE [Antihemophilic Factor (Recombinant)].

22 Dec 2015

CSL submits rIX-FP new drug application to Japan's Pharmaceuticals and Medical Devices Agency

Global biotherapeutics leader CSL Behring announced today that the company has submitted its new drug application to Japan's Pharmaceuticals and Medical Devices Agency for its investigational fusion protein linking recombinant coagulation factor IX with recombinant albumin (rIX-FP).

22 Dec 2015

New drug approved by FDA for treatment of von Willebrand disease

"VONVENDI [von Willebrand factor (Recombinant)]", the new drug from Baxalta Incorporated, a global biopharmaceutical company recently spun off from Baxter International, has just been approved by the United States Food and Drug Administration.

22 Dec 2015

IL obtains 510(k) clearance for ACL TOP Family 50 Series Hemostasis Testing Systems

Instrumentation Laboratory today announced the 510(k) clearance of their latest innovation, the ACL TOP Family 50 Series Hemostasis Testing Systems, by the US Food and Drug Administration.

21 Dec 2015

FDA approves Fenix Continence Restoration System to treat fecal incontinence

The U.S. Food and Drug Administration today approved the Fenix Continence Restoration System to treat fecal incontinence in patients who are not candidates for, or have previously failed, medical or other surgical options.

20 Dec 2015

Poor outlook for ICH associated with novel oral anticoagulants

Haematoma expansion, disability and death are common among patients who have intracerebral haemorrhage while taking novel oral anticoagulants, a study in JAMA Neurology shows.

18 Dec 2015

High testosterone levels in women may increase uterine fibroid risk

Women who have high levels of both testosterone and estrogen in midlife may face a greater risk of developing benign tumors on the uterus called uterine fibroids than women with low levels of the hormones, according to a new study published in the Endocrine Society's Journal of Clinical Endocrinology & Metabolism.

16 Dec 2015

Study: Preoperative use of blood-thinning drugs associated with decreased risk of blood clots

Among patients undergoing major cancer operations, the preoperative use of blood-thinning drugs such as heparin does not increase rates of major bleeding or transfusions, and is associated with a decreased risk of blood clots, according to new study results published online in the Journal of the American College of Surgeons ahead of print publication early next year.

16 Dec 2015

SLU researcher discovered world's first dengue vaccine

A vaccine to prevent dengue fever discovered by a Saint Louis University researcher in 1997 and now licensed worldwide by Sanofi Pasteur has been approved for use in Mexico. Dengvaxia is the world's first vaccine approved to prevent dengue fever, which is a virus spread by mosquitoes primarily in tropical and sub-tropical areas.

15 Dec 2015

New therapeutic target can prevent abnormal blood vessel growth that causes gastrointestinal bleeding

A study by IRB Barcelona and IDIBAPS reveals a therapeutic target to prevent the development of the many abnormal blood vessels that cause gastrointestinal bleeding—the main complication in cirrhosis.

12 Dec 2015

More than half of women may have vulvovaginal symptoms after menopause

After menopause, more than half of women may have vulvovaginal symptoms that have a big impact on their lifestyle, emotions, and sex life. What's more, the symptoms tend to travel with other pelvic troubles, such as prolapse and urinary and bowel problems. But many women aren't getting help, shows a study published online today in Menopause, the journal of The North American Menopause Society.

9 Dec 2015

Treatment with antiplatelet therapy does not reduce pain crises in children with sickle cell disease

Treatment with the antiplatelet agent prasugrel does not significantly reduce the rate of pain crises or severe lung complications in children with sickle cell disease, according to a report published in the New England Journal of Medicine describing one of the largest and most geographically diverse international clinical trials on sickle cell disease to date.

9 Dec 2015

FDA approves recombinant von Willebrand factor for treating bleeding episodes in adults with VWD

The U.S. Food and Drug Administration today approved Vonvendi, von Willebrand factor (Recombinant), for use in adults 18 years of age and older who have von Willebrand disease (VWD). Vonvendi is the first FDA-approved recombinant von Willebrand factor, and is approved for the on-demand (as needed) treatment and control of bleeding episodes in adults diagnosed with VWD.

8 Dec 2015

Researchers find new significant link between NPM protein and development of AML

A team of researchers from the National University of Singapore has found a new significant correlation between the protein nucleophosmin (NPM) and the development of an aggressive form of blood cancer called acute myeloid leukemia (AML).

8 Dec 2015

New technology may facilitate early detection of sickle cell disease for infants in developing countries

Researchers from Seidman Cancer Center at University Hospitals Case Medical Center and Case Western Reserve University School of Medicine presented new research findings this weekend at the 57th Annual Meeting of the American Society of Hematology in Orlando.

8 Dec 2015

WHO’s new checklist targets preventable causes of maternal, newborn deaths in healthcare settings

Worldwide, the majority of maternal and newborn deaths occur around the time of birth, typically within the first 24 hours after childbirth. Most of these deaths are preventable.

8 Dec 2015

FDA clears use of XSTAT 30 wound dressing to control severe bleeding in civilian population

Today, the U.S. Food and Drug Administration cleared the use of the XSTAT 30 wound dressing, an expandable, multi-sponge dressing used to control severe, life-threatening bleeding from wounds in areas that a tourniquet cannot be placed (such as the groin or armpit) in battlefield and civilian trauma settings.

8 Dec 2015

XARELTO reduces rates of major bleeding, recurrent blood clots in people with deep vein thrombosis

Janssen Pharmaceuticals, Inc. and its development partner, Bayer HealthCare, today announced the results from their real-world study XALIA showing that, in people with deep vein thrombosis (DVT), the rates of major bleeding and recurrent blood clots for XARELTO (rivaroxaban) in routine clinical practice were generally consistent with those observed in Phase 3 research.

7 Dec 2015

Gene therapy shows promise in children with Wiskott-Aldrich syndrome

Researchers reported promising preliminary outcomes for the first four children enrolled in a U.S. gene therapy trial for Wiskott-Aldrich syndrome (WAS), a life-threatening genetic blood and immune disorder, at the 57th annual meeting of the American Society of Hematology (abstract #260).

7 Dec 2015

Bleeding News and Research

Women suffering from blood clots can safely take hormone replacement therapy with anticoagulants

Baxalta announces initial results from ADYNOVATE Phase 3 trial for treatment of hemophilia patients

CSL submits rIX-FP new drug application to Japan's Pharmaceuticals and Medical Devices Agency

New drug approved by FDA for treatment of von Willebrand disease

IL obtains 510(k) clearance for ACL TOP Family 50 Series Hemostasis Testing Systems

FDA approves Fenix Continence Restoration System to treat fecal incontinence

Poor outlook for ICH associated with novel oral anticoagulants

High testosterone levels in women may increase uterine fibroid risk

Study: Preoperative use of blood-thinning drugs associated with decreased risk of blood clots

SLU researcher discovered world's first dengue vaccine

New therapeutic target can prevent abnormal blood vessel growth that causes gastrointestinal bleeding

More than half of women may have vulvovaginal symptoms after menopause

Treatment with antiplatelet therapy does not reduce pain crises in children with sickle cell disease

FDA approves recombinant von Willebrand factor for treating bleeding episodes in adults with VWD

Researchers find new significant link between NPM protein and development of AML

New technology may facilitate early detection of sickle cell disease for infants in developing countries

WHO’s new checklist targets preventable causes of maternal, newborn deaths in healthcare settings

FDA clears use of XSTAT 30 wound dressing to control severe bleeding in civilian population

XARELTO reduces rates of major bleeding, recurrent blood clots in people with deep vein thrombosis

Gene therapy shows promise in children with Wiskott-Aldrich syndrome

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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