Immune Response News and Research

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Study reveals improved immunogenicity and safety of bivalent Omicron-containing mRNA-1273.214 candidate booster vaccine

In a new study, a team of researchers assessed the safety and efficacy of a bivalent candidate vaccine containing spike messenger ribonucleic acids of the ancestral Wuhan-Hu-1 strain and the Omicron B.1.1.529 [BA.1] variant of SARS-CoV-2.

21 Sep 2022

Clinical and epidemiologic features of SARS-CoV-2 in companion animals

In a recent study posted to the Research Square* preprint server, researchers explored the clinical and epidemiologic characteristics of coronavirus disease 2019 (COVID-19) in dogs and cats.

21 Sep 2022

Combination of three existing drugs extends survival in mouse models of lethal brain cancer

A Ludwig Cancer Research study has identified a combination of three existing drugs that significantly extends survival in mouse models of the lethal brain cancer glioblastoma multiforme (GBM).

20 Sep 2022

Link between type 2 diabetes and UTIs explained

Lower immunity and recurring infections are common in type 1 and type 2 diabetes. Researchers at Karolinska Institutet in Sweden now show that the immune system of people with diabetes has lower levels of the antimicrobial peptide psoriasin, which compromises the urinary bladder's cell barrier, increasing the risk of urinary tract infection.

20 Sep 2022

Regular fish oil consumption found effective in preventing severe COVID-19 outcomes

In a new study, researchers investigated whether regular fish oil use decreased the risk of contracting severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

20 Sep 2022

COVID-19 during pregnancy damages the placenta's immune response to further infections

If a woman contracts COVID-19 during her pregnancy, the infection, even if it's mild, damages the placenta's immune response to further infections, a UW Medicine-led study has found.

19 Sep 2022

Needle-free jet injection of novel COVID-19 DNA vaccine shows promise in animal model

In a recent study posted to the bioRxiv* server, researchers at the United States Army Medical Research Institute of Infectious Diseases evaluated the immunogenicity of a severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) deoxyribonucleic acid (DNA) vaccine, nCOV-S(JET), in rhesus macaques

18 Sep 2022

Patients with autoimmune diseases at greater risk of complications after heart attack

In a recent study published in the Journal of the American Heart Association, researchers assessed midterm and management outcomes of acute myocardial infarction (AMI) among patients with rheumatic immune-mediated inflammatory diseases (IMIDs).

18 Sep 2022

An improved COVID-19 vaccine shows promise against Omicron in experimental models

In a recent study published in the journal Science Translational Medicine, researchers in the United States designed a bivalent coronavirus disease 2019 (COVID-19) vaccine on the messenger ribonucleic acid (mRNA) platform.

18 Sep 2022

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

This study is led by Dr. Ruifu Yang, Dr. Zongmin Du (State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology) and Dr. Fan Bai (Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University).

16 Sep 2022

New mechanism may prevent the natural aging of immune cells

A new mechanism that slows down and may even prevent the natural aging of immune cells – one of the nine 'hallmarks of aging' – has been identified by an international team led by UCL scientists.

15 Sep 2022

Disruption of actin cytoskeleton is key to triggering human immune response, research finds

Researchers from Cleveland Clinic's Florida Research and Innovation Center (FRIC) found that disruption of a cellular structure, known as the actin cytoskeleton, is a "priming signal" for the body to respond to a virus.

15 Sep 2022

New immunotherapy approach may lead to an effective treatment for fibrosis

Chronic diseases often lead to fibrosis, a condition in which organ tissue suffers from excessive scarring.

15 Sep 2022

Development of improved monoclonal antibodies against SARS-CoV-2

In a new study, researchers explored strategies for the development of effective monoclonal antibodies (mAbs) against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2).

15 Sep 2022

Vaccine-derived poliovirus 2 detected in environmental samples in the UK and USA

Over the last few months, poliovirus 2 derived from the strain used in the Sabin vaccine (oral polio vaccine) has been repeatedly detected in environmental samples in the USA as well as in the UK. What does this signify?

15 Sep 2022

Mechanism of action of different COVID-19 vaccines

In a recent study posted to the bioRxiv* preprint server, researchers at the University of Tuebingen and Imperial College London assessed humoral and cellular immune responses elicited by the recombinant adenoviral vector (rAdVV)- and messenger ribonucleic acid (mRNA)-based coronavirus disease 2019 (COVID-19) vaccines.

14 Sep 2022

High levels of mucosal antibodies in the airways reduce the risk of omicron infection

High levels of mucosal antibodies in the airways reduce the risk of being infected by omicron, but many do not receive detectable antibodies in the airways despite three doses of the SARS-CoV-2 vaccine.

14 Sep 2022

Study highlights the efficacy of MVA-BN booster vaccination in inducing durable B cell memory responses against monkeypox

In a new study, researchers assessed the immunogenicity, safety, and booster-efficacy of the Modified Vaccinia virus Ankara-Bavarian Nordic (MVA-BN) vaccine currently being used for immunization against monkeypox.

14 Sep 2022

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

A new study describes the changes in immune T cell profile over time following monkeypox infection.

14 Sep 2022

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

In a recent study published in the journal eBioMedicine, researchers in Denmark and Sweden administered a cationic liposome-adjuvanted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit vaccine as a subcutaneous (s.c.) prime-intranasal (i.n.) boost strategy to elicit mucosal immune responses among SARS-CoV-2-infected Syrian hamsters.

14 Sep 2022

Immune Response News and Research

Study reveals improved immunogenicity and safety of bivalent Omicron-containing mRNA-1273.214 candidate booster vaccine

Clinical and epidemiologic features of SARS-CoV-2 in companion animals

Combination of three existing drugs extends survival in mouse models of lethal brain cancer

Link between type 2 diabetes and UTIs explained

Regular fish oil consumption found effective in preventing severe COVID-19 outcomes

COVID-19 during pregnancy damages the placenta's immune response to further infections

Needle-free jet injection of novel COVID-19 DNA vaccine shows promise in animal model

Patients with autoimmune diseases at greater risk of complications after heart attack

An improved COVID-19 vaccine shows promise against Omicron in experimental models

Single-cell RNA sequencing reveals dynamic immune landscape during the early stages of bubonic plague

New mechanism may prevent the natural aging of immune cells

Disruption of actin cytoskeleton is key to triggering human immune response, research finds

New immunotherapy approach may lead to an effective treatment for fibrosis

Development of improved monoclonal antibodies against SARS-CoV-2

Vaccine-derived poliovirus 2 detected in environmental samples in the UK and USA

Mechanism of action of different COVID-19 vaccines

High levels of mucosal antibodies in the airways reduce the risk of omicron infection

Study highlights the efficacy of MVA-BN booster vaccination in inducing durable B cell memory responses against monkeypox

The kinetics of T cell response, the inflammatory profile, and the pox-specific T cell induction in monkeypox infection

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

Understanding the DNA Damage Response in Innate Immunity eBook

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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