Mouse Model News and Research

RSS

Researchers reveal ineffectiveness of some treatments in tackling early-stage lung cancer

Researchers from Tohoku University and Tohoku University Hospital have revealed why some existing cancer treatments are ineffective in tackling the early-stages of lung cancer. A team led by Professor Tetsuya Kodama investigated the ability of anti-cancer agents to affect early-stage lung metastatic tumors.

27 Nov 2019

FDA-approved anti-inflammatory drug delays onset of ALS in mice

The cause of amyotrophic lateral sclerosis (ALS)--a disabling neurodegenerative disease that affects nerve cells in the brain and spinal cord and leads to weakened muscles and early death--is not fully understood, but accumulating evidence suggests that inflammatory processes may play a role in the initiation and progression of the condition.

27 Nov 2019

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

Oligomerix, Inc., a privately held company pioneering the development of tau oligomer inhibitors for Alzheimer's disease and related neurodegenerative disorders, and the Feinstein Institutes for Medical Research announced today the publication of preclinical data demonstrating that an oral small molecule drug inhibits the formation of neurotoxic tau oligomers in an animal model of tau aggregation most relevant to AD.

26 Nov 2019

New way to thwart HIV infection at early stages

1.7 million. That's how many people are infected with the human immunodeficiency virus (HIV) each year worldwide. 1.7 million people who are condemned to lifelong antiretroviral therapy (ART) or risk developing fatal AIDS . Out of the 37.9 million people living with HIV (PLWH), 22.3 million have access to ART, allowing them to have an almost normal lifespan.

26 Nov 2019

Researchers find new way to protect against disease in MS model

Researchers have found a new and unexpected way of preventing disease in a preclinical model of multiple sclerosis (MS).

26 Nov 2019

Hops compounds may combat metabolic syndrome by changing the gut microbiome

Compounds from hops may combat metabolic syndrome by changing the gut microbiome and altering the metabolism of acids produced in the liver, new research at Oregon State University suggests.

26 Nov 2019

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

Charitharth Vivek Lal, M.D., and University of Alabama at Birmingham colleagues have used a novel and first-of-its-kind newborn mouse model to study the effect of high oxygen concentrations, or hyperoxia, on lung development of newborn mice that are germ-free -- meaning no microbes colonizing their lungs.

21 Nov 2019

Researchers elucidate role of inflammation resolution sensor in obesity and heart failure

After heart attack injury, several fatty-acid-derived bioactive molecules -- including one called resolvin D1 -- play an essential signaling role to safely clear inflammation and help repair heart muscle. The mechanism of how this resolution occurs is not well-understood.

20 Nov 2019

Cell factors decide if a cancer grows or dies, says new study

A new study published today in the journal Cell Reports by scientists at the German Cancer Research Center (DKFZ) shows that the direction taken by a cancer cell depends on the configuration of the cell itself as well as the activation of a universal cancer cell receptor called CD95.

19 Nov 2019

Dopamine may worsen lung inflammation in asthma

A new study on a mouse model of asthma shows that nerve cells producing dopamine, a neurotransmitter, signal T cells in the body to promote inflammation due to allergic reactions in the lungs during childhood but not in adult mice.

19 Nov 2019

Rutgers Cancer Institute researchers awarded $2.3 million in American Cancer Society grants

More than $2.3 million in Research Scholar Grants from the American Cancer Society have been awarded to three Rutgers Cancer Institute of New Jersey researchers to examine cell metabolism and tumor formation in forms of breast cancer, lung cancer and leukemia.

19 Nov 2019

Newly discovered cell involved in rheumatoid arthritis could serve as treatment target

Researchers have made a discovery about a class of cells involved in rheumatoid arthritis that could instigate new treatments.

18 Nov 2019

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated with the condition -- the leading genetic cause of cognitive disability and the most frequently diagnosed chromosomal disorder in the U.S. -- with drugs that target the body's response to cellular stresses.

15 Nov 2019

Research explains why immunotherapy fails against prostate cancer bone metastases

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that, in turn, thwarts the effectiveness of immune checkpoint inhibitors by blocking the development of T cells that are crucial to successful treatment, researchers from The University of Texas MD Anderson Cancer Center report in Cell.

14 Nov 2019

Inhaled nanoparticles can help treat lung cancer

Scientists have reported a new approach to treating lung cancer with inhaled nanoparticles developed at Wake Forest School of Medicine, part of Wake Forest Baptist Health.

14 Nov 2019

Promising method to identify aggressive breast cancers that will respond to immunotherapy

University of North Carolina Lineberger Comprehensive Cancer Center researchers have discovered a promising method to identify aggressive breast cancer tumors that will respond to drugs that unleash the immune system against cancer.

14 Nov 2019

Blocking metastasis-promoting enzyme can prevent spread of breast cancer

In a breakthrough with important implications for the future of immunotherapy for breast cancer, UC San Francisco scientists have found that blocking the activity of a single enzyme can prevent a common type of breast cancer from spreading to distant organs.

14 Nov 2019

UAB study suggests potential treatment target for IPF

Long-held dogma says lung fibrosis in diseases like idiopathic pulmonary fibrosis, or IPF, results from recurrent injury to alveolar epithelium that is followed by dysregulated repair.

12 Nov 2019

Scientists identify new mechanism for the development of Parkinson's disease

An international research team including scientists from the University of Cologne have identified a new mechanism for the development of Parkinson's disease, which could prove to be the starting point for the development of a more targeted therapy.

12 Nov 2019

Contraceptive drug effective in preventing and regressing cervical cancer in mice

A new study in The American Journal of Pathology, published by Elsevier, reports that medroxyprogesterone acetate (MPA), the active ingredient in the common contraceptive injection Depo-Provera, was effective in preventing the development of cervical cancer in mice with precancerous lesions.

12 Nov 2019

Mouse Model News and Research

Researchers reveal ineffectiveness of some treatments in tackling early-stage lung cancer

FDA-approved anti-inflammatory drug delays onset of ALS in mice

Oligomerix and Feinstein Institutes publish preclinical data of Alzheimer's disease treatment

New way to thwart HIV infection at early stages

Researchers find new way to protect against disease in MS model

Hops compounds may combat metabolic syndrome by changing the gut microbiome

Researchers study the effects of hyperoxia on the lung development of germ-free newborn mice

Researchers elucidate role of inflammation resolution sensor in obesity and heart failure

Cell factors decide if a cancer grows or dies, says new study

Dopamine may worsen lung inflammation in asthma

Rutgers Cancer Institute researchers awarded $2.3 million in American Cancer Society grants

Newly discovered cell involved in rheumatoid arthritis could serve as treatment target

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

Research explains why immunotherapy fails against prostate cancer bone metastases

Inhaled nanoparticles can help treat lung cancer

Promising method to identify aggressive breast cancers that will respond to immunotherapy

Blocking metastasis-promoting enzyme can prevent spread of breast cancer

UAB study suggests potential treatment target for IPF

Scientists identify new mechanism for the development of Parkinson's disease

Contraceptive drug effective in preventing and regressing cervical cancer in mice

Advancing Neuroscience Research Through Collaboration and Patient-Centered Innovation

The impact of vibration on microscopy

How Omics Technologies Are Transforming Biological Research and Drug Discovery

Latest News