OCT News and Research

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Pitt researchers to contribute to building an atlas of cellular senescence

Most cells throughout the body can divide and multiply to replace old cells and repair damaged tissue, but in response to certain stresses, cells can lose their ability to proliferate. These so-called senescent cells accumulate with age and may contribute to cancer and age-related disorders, such as chronic lung disease, cardiovascular disease, frailty and dementia, by pumping out signals that damage neighboring tissues.

21 Oct 2021

New system aims to maximize protection, minimize costs while planning epidemic interventions

A team of researchers has created a software system designed to model epidemics, with the aim of maximizing public-health protections while minimizing economic and social costs.

21 Oct 2021

Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension

By combining computational and experimental approaches, University of Pittsburgh School of Medicine and Prairie View A&M University researchers identified cancer drugs that show promise for treating pulmonary hypertension, or PH, a rare and incurable lung disease.

21 Oct 2021

Skeletal muscle in individuals with type 2 diabetes has a different circadian rhythm, research shows

Almost all cells regulate their biological processes over a 24-hour period, otherwise called a cell's circadian rhythm. To do so, cells use a biological clock that cycles different genes on and off throughout the day and night. Scientists already know that our metabolic health can suffer when our biological clock breaks down, due to shift work or sleep disorders, for example. However, it's unclear how exactly the biological clock of people with type 2 diabetes differs from healthy people.

21 Oct 2021

Research reveals the mechanisms of cardiac sex disparities at an early stage

Males and females differ in prevalence, treatment responses, and survival rates for a variety of diseases. For cardiac disease, women almost uniformly fare far worse than men. There are likely many reasons for this, and scientists at the University of North Carolina at Chapel Hill and Princeton University seemed to have found one deep inside cells before we're even born.

21 Oct 2021

Researchers challenge long-held assumption about ML trade-offs in public policy decisions

Carnegie Mellon University researchers are challenging a long-held assumption that there is a trade-off between accuracy and fairness when using machine learning to make public policy decisions.

21 Oct 2021

Interferon treatment coupled with bone marrow transplant reduces risk of leukemia recurrence

Researchers at the University of Michigan Health Rogel Cancer Center have identified a drug that, when given along with a bone marrow transplant, drops the risk of leukemia recurring by 20% among the high-risk patients.

21 Oct 2021

First-in-human study of DBS for post-stroke rehabilitation shows encouraging results

Targeting the dentate nucleus with deep brain stimulation (DBS) was safe and feasible for promoting post-stroke rehabilitation in a first-in-human study at Cleveland Clinic.

21 Oct 2021

Study reveals an alternative mechanism for muscle tissue repair after physiological damage

Muscle is known to regenerate through a complex process that involves several steps and relies on stem cells.

21 Oct 2021

Playing elite rugby may affect cognitive function in older age, study shows

Retired male elite rugby union players aged 50+ who suffered three or more rugby-related concussions during their career have no worse average cognitive function than those who had experienced no, one or two concussions, according to a new study in Alzheimer's & Dementia: The Journal of the Alzheimer's Association.

21 Oct 2021

UW Medicine receives NIH support to study aging cells

Efforts to understand aging cells in human tissues have received increased support from the National Institutes of Health.

20 Oct 2021

New discovery can pave the way to better diagnostics and therapeutics for asthma and COPD

Rutgers researchers have discovered that people with asthma and chronic obstructive pulmonary disease have a protein in their lungs that leaks a small molecule into their bloodstream that restricts their breathing instead of relaxing their airways.

20 Oct 2021

Discovery could lead to new treatments for axial spondyloarthritis

In a paper published today in the journal Science Translational Medicine, researchers at the Schroeder Arthritis Institute, part of University Health Network in Toronto, have made a discovery that could lead to new treatments for axial spondyloarthritis (SpA), a painful and debilitating form of arthritis which affects 1-2% of Canadians and causes inflammation in the spine, joints, eyes, gut and skin.

20 Oct 2021

Study offers clues to why calorie-restricted diet may slow tumor growth

In recent years, there has been some evidence that dietary interventions can help to slow the growth of tumors.

20 Oct 2021

Using hydrogel barriers to effectively prevent post-surgical adhesions

Following surgery within the abdominal or pelvic cavities, scar tissue often forms on the inner linings of these cavities and may adhere to the organs which are found within them.

20 Oct 2021

Depression, anxiety in pregnant women may increase the likelihood of cesarean deliveries

Depression and anxiety in pregnant women may be connected to the type of delivery they have, new research suggests.

20 Oct 2021

Researchers launch new project for improving the ability to predict, respond to future pandemics

A multidisciplinary national research team led by University of Utah Health scientists has launched a comprehensive review and analysis of data collected about COVID-19 in hopes of improving the nation’s ability to predict, detect, and respond to future pandemics.

20 Oct 2021

Researchers discover crucial role of glial cells in maintaining healthy gut immunity

Researchers at the Francis Crick Institute have uncovered a fundamental role of glial cells in the nervous system of the gut in maintaining a healthy intestine.

20 Oct 2021

Researchers identify new gene variants that may cause inherited retinal dystrophies

An international team of researchers, led by scientists at University of California San Diego and Shiley Eye Institute at UC San Diego Health, has broadened and deepened understanding of how inherited retinal dystrophies (IRDs) affect different populations of people and, in the process, have identified new gene variants that may cause the diseases.

20 Oct 2021

New approach to predict the enzyme activity using AI

Without enzymes, an organism would not be able to survive. It is these biocatalysts that facilitate a whole range of chemical reactions, producing the building blocks of the cells. Enzymes are also used widely in biotechnology and in our households, where they are used in detergents, for example.

20 Oct 2021

OCT News and Research

Pitt researchers to contribute to building an atlas of cellular senescence

New system aims to maximize protection, minimize costs while planning epidemic interventions

Researchers employ novel algorithm to identify candidate cancer drugs for pulmonary hypertension

Skeletal muscle in individuals with type 2 diabetes has a different circadian rhythm, research shows

Research reveals the mechanisms of cardiac sex disparities at an early stage

Researchers challenge long-held assumption about ML trade-offs in public policy decisions

Interferon treatment coupled with bone marrow transplant reduces risk of leukemia recurrence

First-in-human study of DBS for post-stroke rehabilitation shows encouraging results

Study reveals an alternative mechanism for muscle tissue repair after physiological damage

Playing elite rugby may affect cognitive function in older age, study shows

UW Medicine receives NIH support to study aging cells

New discovery can pave the way to better diagnostics and therapeutics for asthma and COPD

Discovery could lead to new treatments for axial spondyloarthritis

Study offers clues to why calorie-restricted diet may slow tumor growth

Using hydrogel barriers to effectively prevent post-surgical adhesions

Depression, anxiety in pregnant women may increase the likelihood of cesarean deliveries

Researchers launch new project for improving the ability to predict, respond to future pandemics

Researchers discover crucial role of glial cells in maintaining healthy gut immunity

Researchers identify new gene variants that may cause inherited retinal dystrophies

New approach to predict the enzyme activity using AI

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