Vascular News and Research

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Exploring the systemic infection of SARS-CoV-2 in a wild leopard in India

A new study focused on the pathomorphological and virological characterization of SARS-CoV-2 in naturally infected, wild Indian Leopard.

17 Jan 2022

Protein biomarkers in urine could be used to diagnose concussion and monitor recovery

Concussion can be frustratingly hard to diagnose and track. The injury doesn't show up on routine brain scans, and there is no definitive diagnostic test. It's usually diagnosed based on symptoms, and, in athletes, comparison with baseline testing if it was done. But concussion symptoms are non-specific, unreliable, and easily influenced by emotions.

17 Jan 2022

Genome editing in vascular endothelial cells made possible with a powerful new delivery system

Northwestern Medicine scientists developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which line blood vessel walls.

16 Jan 2022

Research could advance the understanding of links between heart disease and dementia

Heart disease can directly cause brain dysfunction early on which could lead to dementia and can treble the amount of an Alzheimer's protein in the brain, say scientists.

13 Jan 2022

Harmful effects of SARS-CoV-2 infection in pregnant women and their newborns

Pregnant women should get vaccinated to minimize the detrimental health effects COVID-19 has on the placenta, the fetus and the newborn, states Roberta L. DeBiasi, M.D., M.S., division chief of Pediatric Infectious Diseases at Children's National Hospital in an editorial published in The Journal of Infectious Diseases.

13 Jan 2022

Macrophages in the arteries can "sniff" out their surroundings and cause inflammation

An artery is not like a nose. Or is it? Scientists at La Jolla Institute for Immunology (LJI) have discovered that immune cells in arteries can "sniff" out their surroundings and cause inflammation.

13 Jan 2022

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

A new study reveals the existence of a powerful ally in the fight against cardiovascular disease, a protective subset of vascular macrophages expressing the C-type lectin receptor CLEC4A2, a molecule which fosters "good" macrophage behavior within the vessel wall.

11 Jan 2022

Researchers discover a potential depression biomarker and why it affects women and men differently

A team of Université Laval scientists may have discovered why severe depression affects women and men differently, according to a study published today in Nature Communications.

10 Jan 2022

Fewer than 1 in 5 U.S. adults with Type 2 diabetes meet targets to reduce heart disease risk

Fewer than 1 in 5 adults with Type 2 diabetes in the U.S. are meeting targets to reduce heart disease risk. Fortunately, available therapies can help when combined with new approaches that address social determinants of health and other barriers to care, according to a new American Heart Association scientific statement published today in the Association's flagship journal Circulation.

10 Jan 2022

Dual-receptors help widespread dissemination of SARS-CoV-2

Researchers demonstrate the role of integrins in the establishment of the SARS-CoV-2 infection.

9 Jan 2022

SARS-CoV-2 Omicron less pathogenic in hamsters

A new research paper posted as a preprint to the bioRxiv* server attempts to throw some light on this question by studying viral pathogenicity in golden hamsters, a valuable model for severe COVID-19 due to the development of reproducible weight loss and pneumonia after infection with the virus.

6 Jan 2022

Study estimates the global prevalence of dementia in 2050

The number of adults (aged 40 years and older) living with dementia worldwide is expected to nearly triple, from an estimated 57 million in 2019 to 153 million in 2050, due primarily to population growth and population aging.

6 Jan 2022

Researchers explore novel strategy to improve the reprogramming efficiency of human fibroblasts

Not too long ago the idea of taking, for instance a skin cell and transforming it into a muscle cell was unthinkable. About 10 years ago, however, revolutionary research showed that it is indeed possible to reprogram differentiated adult cells into other types fully capable of conducting new functions.

6 Jan 2022

Study finds all three proteins required for SARS-CoV-2 infection present in human glossopharyngeal and vagal nerves

Researchers explored the presence of coronavirus receptors in the glossopharyngeal and vagal cranial nerves.

6 Jan 2022

Melatonin found to inhibit SARS-CoV-2 entry into mice brains

New research recently unveiled the utility of melatonin and melatonin-derived medicines in reducing brain entry of severe acute respiratory syndrome coronavirus 2 and subsequently preventing long-term neurological consequences of coronavirus disease 2019.

6 Jan 2022

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

The LIVE-AIR phase 3 clinical trial is associated with early treatment of hyperinflammatory response with the humanized monoclonal antibody lenzilumab in COVID-19 patients with decreased oxygen saturation. The study results are posted to the medRxiv* preprint server.

6 Jan 2022

Change in glutathione reductase lowers inflammation in present-day humans

Very few proteins in the body have a change that makes them unique compared to the corresponding proteins in Neanderthals and apes.

5 Jan 2022

FAU researchers urge to prescribe aspirin based on benefit-to-risk not age

Recent guidelines have restricted aspirin use in the primary prevention of cardiovascular disease to patients under 70, and more recent guidance to patients under 60. Yet, the risks of heart attacks and strokes increase markedly with age.

5 Jan 2022

Study uncovers a harmful neutrophil behavior linked to cardiovascular disease

Scientists led by Dr. Andrés Hidalgo at the Centro Nacional de Investigadores Cardiovasculares have discovered that circulating neutrophils - a type of immune cell - acquire different behavior patterns during inflammatory processes.

5 Jan 2022

Erectile dysfunction medication found to intensify abdominal aortic aneurysms in mice

In a laboratory study in mice, sildenafil, a commonly used erectile dysfunction medication, was found to worsen abdominal aortic aneurysms, indicating additional research may be needed to determine if the medication may have the same effect on people, according to new research published today in the Journal of the American Heart Association, an open access, peer-reviewed journal of the American Heart Association.

5 Jan 2022

Vascular News and Research

Exploring the systemic infection of SARS-CoV-2 in a wild leopard in India

Protein biomarkers in urine could be used to diagnose concussion and monitor recovery

Genome editing in vascular endothelial cells made possible with a powerful new delivery system

Research could advance the understanding of links between heart disease and dementia

Harmful effects of SARS-CoV-2 infection in pregnant women and their newborns

Macrophages in the arteries can "sniff" out their surroundings and cause inflammation

Study finds a subset of vascular macrophages to be powerful ally in the fight against atherosclerosis

Researchers discover a potential depression biomarker and why it affects women and men differently

Fewer than 1 in 5 U.S. adults with Type 2 diabetes meet targets to reduce heart disease risk

Dual-receptors help widespread dissemination of SARS-CoV-2

SARS-CoV-2 Omicron less pathogenic in hamsters

Study estimates the global prevalence of dementia in 2050

Researchers explore novel strategy to improve the reprogramming efficiency of human fibroblasts

Study finds all three proteins required for SARS-CoV-2 infection present in human glossopharyngeal and vagal nerves

Melatonin found to inhibit SARS-CoV-2 entry into mice brains

LIVE-AIR trial demonstrates efficacy of Lenzilumab for treatment of COVID patients with decreased oxygen saturation

Change in glutathione reductase lowers inflammation in present-day humans

FAU researchers urge to prescribe aspirin based on benefit-to-risk not age

Study uncovers a harmful neutrophil behavior linked to cardiovascular disease

Erectile dysfunction medication found to intensify abdominal aortic aneurysms in mice

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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