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Applying deep neural networks to predict pharmacologic properties of drugs and drug repurposing

Deep learning, frequently referred to as artificial intelligence, a branch of machine learning utilizing multiple layers of neurons to model high-level abstractions in data, has outperformed humans in tasks including image, text and voice recognition, autonomous driving and others, and is now being applied to drug discovery and biomarker development.

28 May 2016

Researchers develop new drugs for melanoma

Finding new, more effective and personalised treatments for cancer is the challenge of many researchers. A challenge that has been successfully met by a team from Inserm led by Stéphane Rocchi, which has just synthesised and developed new drugs for melanoma.

28 May 2016

Brivaracetam drug shows no added benefit for epilepsy

Brivaracetam (trade name: Briviact) has been approved since January 2016 as add-on therapy for adolescents from the age of 16 years and adults with epileptic seizures. The German Institute for Quality and Efficiency in Health Care now examined in an early benefit assessment whether this drug offers an added benefit for patients in comparison with the appropriate comparator therapy.

28 May 2016

Study identifies potential new treatment for subset of gastric cancer patients

Testing cancers for 'addiction' to a gene that boosts cell growth can pick out patients who may respond to a targeted drug under development, a major new study reports.

28 May 2016

Increasing specific microRNA levels can restore chemotherapy sensitivity in pancreatic cancer cells

By increasing the level of a specific microRNA (miRNA) molecule, researchers have for the first time restored chemotherapy sensitivity in vitro to a line of human pancreatic cancer cells that had developed resistance to a common treatment drug.

27 May 2016

FDA finalizes new food safety rule to prevent wide-scale public health harm

The U.S. Food and Drug Administration today finalized a new food safety rule under the landmark, bipartisan FDA Food Safety Modernization Act that will help to prevent wide-scale public health harm by requiring companies in the United States and abroad to take steps to prevent intentional adulteration of the food supply.

27 May 2016

New understanding of neurotransmitter transporter mechanism gives hope for treating depression, addicition

When nerve cells have to communicate with each other in our brains, it involves release of small signal molecules, the so-called neurotransmitters, which act as chemical messengers in specific points of contact between nerve cells, called synapses.

27 May 2016

First buprenorphine implant for opioid dependence treatment gets FDA approval

The U.S. Food and Drug Administration today approved Probuphine, the first buprenorphine implant for the maintenance treatment of opioid dependence. Probuphine is designed to provide a constant, low-level dose of buprenorphine for six months in patients who are already stable on low-to-moderate doses of other forms of buprenorphine, as part of a complete treatment program.

27 May 2016

Novel way of directly activating Bak protein can trigger cell death

Melbourne researchers have discovered a new way of triggering cell death, in a finding that could lead to drugs to treat cancer and autoimmune disease.

27 May 2016

Drexel scientists identify how two new antimalarial drugs work

Drexel University scientists have discovered an unusual mechanism for how two new antimalarial drugs operate: They give the parasite's skin a boost in cholesterol, making it unable to traverse the narrow labyrinths of the human bloodstream.

27 May 2016

Small drug-like molecule that alters perception of food may hold key to extending human healthspan

Researchers at the Buck Institute have shown a new effect on aging via a small drug-like molecule that alters the perception of food in the nematode C. elegans. Publishing in Aging Cell, researchers "tricked" the worm's metabolism into a state of caloric restriction, extending the animal's lifespan by 50 percent.

27 May 2016

Researcher explores whether DBS can help improve life of bipolar disorder patients

Jennifer Sweet, MD, a neurosurgeon at University Hospitals Case Medical Center, recently opened a clinical research study to learn if there is a structural target in the brain for patients suffering from bipolar disorder and whether deep brain stimulation (DBS) can bring them relief.

27 May 2016

UPMC study gives better understanding of cardiac arrhythmia following lung transplantation

Cardiac arrhythmia is a common complication following lung transplantation, and one that has a significant negative impact on long-term patient survival, reports a team of UPMC researchers in the largest study of its kind to date.

27 May 2016

Study reveals males and females exhibit different stress responses

How does stress - which, among other things, causes our bodies to divert resources from non-essential functions - affect the basic exchange of materials that underlies our everyday life? Weizmann Institute of Science researchers investigated this question by looking at a receptor in the brains of mice, and they came up with a surprising answer.

27 May 2016

Accumulation of gut bacterial metabolite may lead to serious health problems in CKD patients

In patients with chronic kidney disease (CKD), the accumulation of a gut bacterial metabolite that's normally excreted in urine may contribute to serious health problems. The findings come from a study appearing in an upcoming issue of the Journal of the American Society of Nephrology.

27 May 2016

Drugs News and Research

Applying deep neural networks to predict pharmacologic properties of drugs and drug repurposing

Researchers develop new drugs for melanoma

Brivaracetam drug shows no added benefit for epilepsy

Study identifies potential new treatment for subset of gastric cancer patients

Increasing specific microRNA levels can restore chemotherapy sensitivity in pancreatic cancer cells

FDA finalizes new food safety rule to prevent wide-scale public health harm

New understanding of neurotransmitter transporter mechanism gives hope for treating depression, addicition

First buprenorphine implant for opioid dependence treatment gets FDA approval

Novel way of directly activating Bak protein can trigger cell death

Drexel scientists identify how two new antimalarial drugs work

Small drug-like molecule that alters perception of food may hold key to extending human healthspan

Researcher explores whether DBS can help improve life of bipolar disorder patients

UPMC study gives better understanding of cardiac arrhythmia following lung transplantation

Study reveals males and females exhibit different stress responses

Accumulation of gut bacterial metabolite may lead to serious health problems in CKD patients

Antimuscarinic drugs effective in improving OAB symptoms

Researchers find new clue to understanding 'chemo brain' in cancer patients

New tablet fabrication method can make personalized medicine cheaper, easier

Gene mutation linked to autism plays key role in formation, maturation of synapses

Integrative Body-Mind Training helps reduce smoking

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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