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Researchers use computer simulations to mimic DNA mess inside the nucleus

Almost three metres of tightly-coiled DNA strands fit into a cell's nucleus. As DNA replicates, the strands unwind and unfold and then re-package into chromosomes, the genetic blueprints of life - but what happens if this process becomes entangled?

15 Mar 2006

Capsaicin drives prostate cancer cells to kill themselves

Capsaicin, the stuff that turns up the heat in jalapeqos, not only causes the tongue to burn, it also drives prostate cancer cells to kill themselves, according to studies published in the March 15 issue of Cancer Research.

15 Mar 2006

Cells have a natural defense against HIV

Scientists here have discovered a previously unknown mechanism that cells use to fight off the human immunodeficiency virus (HIV), the cause of AIDS.

14 Mar 2006

Study reveals mechanisms behind Thiazolidinediones used to treat type 2 diabetes

Thiazolidinediones (TZD's) are drugs commonly prescribed to patients with type 2 diabetes, the most common form of diabetes. Current U.S. Food and Drug Administration-approved agents are known as Actos (pioglitazone) and Avandia (rosiglitazone).

13 Mar 2006

Smk-1 is the first known gene that regulates longevity without disrupting life-sustaining function

Within a hormone-triggered cascade of molecular signals that plays a crucial for a wide range of physiological functions, researchers for the very first time have identified a protein that functions specifically to extend lifespan and youthfulness - without disrupting fertility

13 Mar 2006

Nematode hormone discovery may aid fight against parasitic disease

New research at UT Southwestern Medical Center shows that on a biochemical level, hormone-like molecules in tiny worms called nematodes work similarly to the way in which certain hormones work in humans - findings that one day may help eradicate worm infections that afflict a third of the world's population.

9 Mar 2006

Novel device uses light to probe for early signs of cancer

A novel device that could use light to harmlessly and almost instantly probe for early signs of cancer has been developed by researchers at Duke's Pratt School of Engineering.

9 Mar 2006

ATF2 protein may play a crucial role in cancer's ability to resist chemotherapy and radiation treatment

Researchers at Purdue University have discovered a molecular mechanism that may play a crucial role in cancer's ability to resist chemotherapy and radiation treatment and that also may be involved in Alzheimer's and heart disease.

9 Mar 2006

Newly identified biomarkers may help reverse the ageing process

Lotions and potions that promise to remove wrinkles and other effects of aging crowd cosmetics aisle shelves, but do these treatments really work?

7 Mar 2006

Study provides new evidence of the importance of reward pathways in the brain

Deleting a specific gene in the brain has the same effect that antidepressants do in mice that have been conditioned to be depressed, report researchers at UT Southwestern Medical Center.

24 Feb 2006

Discovery of molecule that may hold key to learning and memory

Independent research teams from Harvard Medical School and Children's Hospital Boston have identified a master protein that sheds light on one of neurobiology's biggest mysteries--how neurons change as a result of individual experiences.

23 Feb 2006

Extract from Scutellaria Barbata may treat breast cancer

A new clinical formulation extracted from a botanical may provide physicians with a new tool in treating aggressive late-stage breast cancer.

21 Feb 2006

Removing a gene involved in repairing damaged DNA causes metabolic syndrome

Removing a gene involved in repairing damaged DNA causes mice to develop the metabolic syndrome, researchers at Oregon Health & Science University have discovered.

21 Feb 2006

Farnesyltransferase inhibitor may improve progeria

UCLA researchers found that an experimental cancer drug improves the signs of progeria in a mouse model. Progeria is a rare genetic disease causing accelerated aging and cardiovascular disease in children. The new UCLA findings help to define a new strategy for treating children with progeria.

17 Feb 2006

Taking aim at one of mankind's most common diseases

A detailed structural picture of a molecule that plays a key role in activating the Epstein Barr Virus in human cells has now been obtained by researchers at the European Molecular Biology Laboratory (EMBL) and the Institute of Molecular and Structural Virology (IVMS), associated with the University Joseph Fourier and the CNRS, in Grenoble.

16 Feb 2006

Gene therapy cures depressed mice

Researchers in the U.S. say that deleting a specific gene in the brain of mice that have been conditioned to be depressed, has the same effect as antidepressants.

13 Feb 2006

Cellular discovery suggests possibilities for drug therapy for kidney disease

Scientists at the University of California, Santa Barbara have reported a discovery at the cellular level that suggests possibilities for drug therapy for kidney disease.

13 Feb 2006

Cancer researchers find evolutionary change that occurred in a key developmental signalling pathway

Cancer researchers at the University of Helsinki, in trying to find a novel tumor suppressor gene, instead found an important evolutionary change that occurred in a key developmental signalling pathway. The finding suggests a potential mechanism for evolution of complex intercellular signalling pathways.

9 Feb 2006

Researchers find new mechanism potentially explaining evolution of signalling pathways

7 Feb 2006

FDA grants fast track status for ViroPharma's Maribavir

ViroPharma Incorporated has announced that the U.S. Food and Drug Administration (FDA) has granted fast track designation for maribavir, an oral antiviral drug candidate for the prevention of cytomegalovirus (CMV) infection in allogeneic bone marrow (stem cell) and solid organ transplant patients.

7 Feb 2006