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Newly identified mechanism may explain why women are more vulnerable to Alzheimer's disease

Case Western Reserve University researchers have identified a mechanism in brain tissue that may explain why women are more vulnerable to Alzheimer's disease - a finding that they say could help lead to new medicines to treat the disease.

4 Oct 2022

What are the challenges of COVID-19 vaccination and herd immunity?

A new study reviewed the challenges of coronavirus disease 2019 (COVID-19) vaccination and herd immunity.

4 Oct 2022

Spike-specific memory B cells develop resilience to SARS-CoV-2

In a recent study posted to the bioRxiv* preprint server, researchers explored the cross-reactivity, avidity, and kinetics of memory B-cells and serum antibodies in vaccinated and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infected individuals.

4 Oct 2022

How COVID-19 affects the female reproductive system

A new review in the Biology of Reproduction journal analyzed the relationship between the immune system and the female reproductive system while focusing on the effects of COVID-19-associated immune responses on the reproductive system. The study searched PubMed to identify peer-reviewed literature in English up to May 2022 and finally included 83 studies.

3 Oct 2022

Study reveals a promising therapeutic target for spinocerebellar ataxia type 14

Spinocerebellar ataxias are a group of neurodegenerative diseases characterized by the degeneration of Purkinje cells, a major class of neurons in the cerebellum.

3 Oct 2022

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

Stanford University researchers have discovered a rapid and sustainable way to synthetically produce a promising cancer-fighting compound right in the lab.

3 Oct 2022

ASU scientists discover an unusual RNA biogenesis pathway

For the very first time, a study led by Julian Chen and his group in Arizona State University's School of Molecular Sciences and the Biodesign Institute's Center for the Mechanism of Evolution, has discovered an unprecedented pathway producing telomerase RNA from a protein-coding messenger RNA (mRNA).

3 Oct 2022

Study provides new insights into the underlying physiology of mevalonate kinase deficiency

A new study from the Garvan Institute of Medical Research shows how rises in core body temperature may trigger the inflammatory flares in people with a rare genetic autoinflammatory disease.

3 Oct 2022

Enzyme found to play a crucial role in guiding cellular response to stress

An enzyme called Fic, whose biochemical role was discovered at UT Southwestern more than a dozen years ago, appears to play a crucial part in guiding the cellular response to stress, a new study suggests.

3 Oct 2022

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Researchers investigated the use of aminoadamantane nitrate compounds as anti-SARS-CoV-2 drugs.

3 Oct 2022

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Researchers evaluated the efficacy, immunogenicity, and safety of a novel SARS-CoV-2 linear deoxyribonucleic acid vaccine in ferret models delivered using intramuscular injection and electroporation.

3 Oct 2022

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

A recent Nature Reviews Immunology study has summarized the efficacy of neutralizing antibodies that target four main regions of the spike (S) protein of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), namely, the receptor-binding domain (RBD) in the S1 subunit, the fusion peptide region in the S2 subunit, the stem helix region, and the N-terminal domain.

2 Oct 2022

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

In a new study, researchers explored the crystalline structure of the monkeypox (MPX) virus (MPXV) and the complex of VP39, a 2′-O-RNA methyltransferase (MTase) and sinefungin, a pan-MTase inhibitor.

30 Sep 2022

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

In a new study, researchers reported severe acute respiratory syndrome coronavirus 2 (SARS-COV-2) spike (S) protein and S messenger ribonucleic acid (mRNA) nuclear co-translocation as a novel feature of SARS-CoV-2 pathogenesis.

30 Sep 2022

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

A new study demonstrated the efficacy of a newly engineered angiotensin-converting enzyme 2 (ACE2) based immunoadhesin against Omicron and other SARS-CoV-2 VOCs.

30 Sep 2022

DNA metagenomic analyses of clinical samples from Monkeypox virus-infected individuals

Researchers analyzed genomic sequences of MPXV obtained from 18 patients who contracted MPXV infection between June and July 2022.

30 Sep 2022

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

Scientists have identified lucidenic acid A, one of the bioactive compounds of Ganoderma lucidum, as a potential inhibitor of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) host cell entry. The study has recently been published in the journal Food and Chemical Toxicology.

29 Sep 2022

A novel method to identify spike stabilizing mutations for COVID-19 vaccine development

Researchers discuss a robust method to identify mutations that improve the expression and stabilize the conformation of the SARS-CoV-2 spike protein.

29 Sep 2022

“Mystery gene” matures a main component of the cell skeleton

"I'm a professional pin-in-a-haystack seeker," geneticist Thijn Brummelkamp responds when asked why he excels at tracking down proteins and genes that other people did not find, despite the fact that some have managed to remain elusive for as long as forty years.

29 Sep 2022

Researchers discover how cancer cells can turn off the immune system to help tumors grow

When cancer arises in the body, it starts with tumor cells that rapidly grow and divide and eventually spread.

29 Sep 2022

Enzyme News and Research

Newly identified mechanism may explain why women are more vulnerable to Alzheimer's disease

What are the challenges of COVID-19 vaccination and herd immunity?

Spike-specific memory B cells develop resilience to SARS-CoV-2

How COVID-19 affects the female reproductive system

Study reveals a promising therapeutic target for spinocerebellar ataxia type 14

Stanford researchers discover a sustainable way to produce cancer-fighting compound in the lab

ASU scientists discover an unusual RNA biogenesis pathway

Study provides new insights into the underlying physiology of mevalonate kinase deficiency

Enzyme found to play a crucial role in guiding cellular response to stress

Researchers report aminoadamantanes that block SARS-CoV-2 infection by S-nitrosylation of the host ACE2 protein

Novel linear DNA SARS-CoV-2 vaccine using electroporation-aided vaccine delivery reveals lower viral shedding in ferrets

Broadly neutralizing antibodies are the blueprint for variant-proof, pansarbecovirus vaccines

Structural analysis of monkeypox virus to guide the development of broad antiviral agents

SARS-CoV-2 spike protein and messenger ribonucleic acid found to translocate into the nucleus

Effectiveness of anti-SARS-CoV-2 immunoadhesin against omicron and other emerging variants

DNA metagenomic analyses of clinical samples from Monkeypox virus-infected individuals

Bioactive compounds derived from Ganoderma lucidum exhibit anti-SARS-CoV-2 activity

A novel method to identify spike stabilizing mutations for COVID-19 vaccine development

“Mystery gene” matures a main component of the cell skeleton

Researchers discover how cancer cells can turn off the immune system to help tumors grow

Measuring Drug-Target Residence Times with Biochemical Assays eBook

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