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Researchers examine p53-deficient colon cancer cells to identify how p53 impacts metabolic adaptation

Colon cancer cells deficient in p53, one of the most important control proteins in cell growth, activate a particular metabolic pathway to adapt to the lack of oxygen and nutrients inside the tumor. Statins, which are often prescribed to lower cholesterol, block this metabolic pathway and cause the cancer cells to die, as scientists from the German Cancer Research Center have now discovered.

12 Dec 2019

Researchers aim to improve oral delivery of insulin for diabetes patients

Diabetes is a chronic disease that occurs when the pancreas does not produce enough insulin -- a hormone that regulates blood sugar-- or the body cannot effectively use the insulin it produces.

12 Dec 2019

Dendritic cells could lead to better treatments for persistent infections, cancer

Autoimmune disorders such as rheumatoid arthritis, psoriasis, and Crohn's disease plague tens of millions of Americans and are the result of the body's immune system, whose role is to fight against disease-causing pathogens, turning against itself.

12 Dec 2019

Researchers making major inroads into finding the cause of different diseases

Australian researchers are making major inroads into finding the cause of heart disease, Alzheimer's, cancer, diabetes and other diseases after discovering a further 148 proteins affected by oxidative stress in the human body.

12 Dec 2019

Extensive tumor protein analysis reveals potential new players in cancer

Looking to gain a deeper understanding of cancer, a team led by researchers at Baylor College of Medicine conducted an extensive computational analysis of the similarities and differences in the entire set of proteins, called the proteome, of more than 500 cancers from five different tissue sites.

12 Dec 2019

Study suggests antiarrhythmic drug as potential treatment for pulmonary arterial hypertension

High blood pressure in the lungs, known as pulmonary arterial hypertension (PAH), is a potentially fatal disease caused by obstruction of blood flow in the lungs.

12 Dec 2019

Immune cells repair damaged gut in children with IBD

According to a new study published in the journal Gastroenterology, immune cells of a certain kind which regulate inflammatory processes and even help restore normal gut function after inflammation could be of great use to treat children with inflammatory bowel disease (IBD).

11 Dec 2019

Gut disease and gene analysis networks

Gut diseases are difficult to diagnose in many cases, and their underlying dysfunction is hard to understand in many cases. Now, a new study published in the journal Molecular Omics promises to uncover a better insight into how these conditions occur and their mechanisms, by providing a deeper look at how genes interact in complex ways in health and fail to do so in disease.

11 Dec 2019

Researchers develop new bio-platform to hear the beat of small clusters of cells

One of the tests that almost every patient must face before a surgery or other health intervention is an electrocardiogram.

11 Dec 2019

Epigenome editing could repair genetic brain disorder

A new study published in the journal Nature Communications shows that it may be possible to reverse gene mutations that cause brain disorders, using a very precisely targeted epigenome editing technique. This type of gene editing does not change the gene’s DNA sequence itself but is focused on correcting epigenome changes only. The condition that was corrected in the study is called the WAGR syndrome and is associated with obesity and intellectual disability in people.

11 Dec 2019

New drug combo promises help for triple negative breast cancer patients

A new preclinical study on triple negative breast cancer (TNBC) reports that an experimental polo-like kinase 1 (PLK1) inhibitor shrank tumor four times more powerfully when used along with standard drugs than alone. The study, reported in the journal PLOS ONE, opens up a new door of opportunity for patients with this disease.

11 Dec 2019

Study reveals mechanism that helps pancreatic cancer cells avoid starvation

A new study reveals the mechanism that helps pancreatic cancer cells avoid starvation within dense tumors by hijacking a process that pulls nutrients in from their surroundings.

11 Dec 2019

Light to moderate lifetime alcohol use raises cancer risk

There have been conflicting reports on health benefits and harm caused by drinking alcohol. A new study from Japanese researchers has proven that taking one drink a day for a decade or two drinks for five years can raise the risk of getting cancers by 5 percent. The study titled “Light to moderate amount of lifetime alcohol consumption and risk of cancer in Japan,” was published in the latest issue of the journal Cancer.

11 Dec 2019

New system enables real-time observations of individual cells in the colon

Biomedical engineers at Duke University have developed a system that allows for real-time observations of individual cells in the colon of a living mouse.

11 Dec 2019

Study could help improve GENUS to become a therapeutic approach for Alzheimer's disease

The sweeping extent to which increasing 40Hz "gamma" rhythm power in the brain can affect the pathology and symptoms of Alzheimer's disease in mouse models has been surprising, even to the MIT neuroscientists who've pioneered the idea. So surprising, in fact, they can't yet explain why it happens.

11 Dec 2019

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

Every organ in the body is capable, to some extent, of repairing itself after an injury. As part of this process, scar tissue forms and then recedes to make room for normal tissue when healing is complete.

11 Dec 2019

New therapy shows dramatic effect against worst types of leukaemias

A collaborative research effort by Australian and US scientists has led to the discovery of a promising new approach to treating some of the worst types of leukaemia, including an aggressive leukaemia that mostly affects babies.

11 Dec 2019

Researchers develop spray gel for frostbite injuries

Mountaineers and winter sports enthusiasts know the dangers of frostbite -- the tissue damage that can occur when extremities, such as the nose, ears, fingers and toes, are exposed to very cold temperatures. However, it can be difficult to get treated quickly in remote, snowbound areas.

11 Dec 2019

Study sheds light on the factors at play in neuroblastoma metastasis

Neuroblastoma can grow and spread in the body very aggressively, making it very difficult to treat. New research has shed important light on the factors at play in the metastasis of neuroblastoma, which could potentially lead to new treatment strategies.

11 Dec 2019

New research may help guide future treatment for non-alcoholic fatty liver disease

Edith Cowan University researchers have found that a chronic disease affecting up to 80 per cent of overweight people may be causing an iron deficiency that simply leaves them too tired to get off the couch.

11 Dec 2019

B Cell News and Research

Researchers examine p53-deficient colon cancer cells to identify how p53 impacts metabolic adaptation

Researchers aim to improve oral delivery of insulin for diabetes patients

Dendritic cells could lead to better treatments for persistent infections, cancer

Researchers making major inroads into finding the cause of different diseases

Extensive tumor protein analysis reveals potential new players in cancer

Study suggests antiarrhythmic drug as potential treatment for pulmonary arterial hypertension

Immune cells repair damaged gut in children with IBD

Gut disease and gene analysis networks

Researchers develop new bio-platform to hear the beat of small clusters of cells

Epigenome editing could repair genetic brain disorder

New drug combo promises help for triple negative breast cancer patients

Study reveals mechanism that helps pancreatic cancer cells avoid starvation

Light to moderate lifetime alcohol use raises cancer risk

New system enables real-time observations of individual cells in the colon

Study could help improve GENUS to become a therapeutic approach for Alzheimer's disease

Researchers develop 'scar in a dish' model to closely mimic progressive organ scarring

New therapy shows dramatic effect against worst types of leukaemias

Researchers develop spray gel for frostbite injuries

Study sheds light on the factors at play in neuroblastoma metastasis

New research may help guide future treatment for non-alcoholic fatty liver disease

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