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Quantum dot nanodevice that can detect and image apoptosis

Aiming to help researchers get a better handle on how - and if - anticancer agents are triggering cell death, investigators at the University of Twente in The Netherlands have developed a quantum dot nanodevice that can detect and image apoptosis, also known as programmed cell death.

5 Sep 2006

Scientists develop magnetic nanoparticles for medicine

Magnetic iron oxide nanoparticles have already proven their utility for imaging metastatic breast cancer lesions in sentinel lymph nodes, and numerous groups are attempting to use iron nanoparticles in other imaging applications.

5 Sep 2006

New method for attaching tumor-targeting antibodies to the surface of buckyballs

Hollow buckyballs, spherical molecules made of sixty carbon atoms linked to one another like the panels of a soccer ball, have the potential to ferry large doses of anticancer drugs or imaging agents to tumors.

5 Sep 2006

Targeted nanoparticles to improve Boron-Neutron capture therapy

Boron-neutron capture therapy (BNCT) is an experimental treatment for virulent brain cancer that aims to kill malignant cells by generating high-energy alpha particles inside tumors.

5 Sep 2006

New methods for screening nanoparticles and interaction with human cells

Scientists have developed a screening method to examine how newly made nanoparticles - particles with dimensions on the order of billionths of a meter - interact with human cells following exposure for various times and doses.

21 Aug 2006

Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung

Drug developers consider the lungs to be an excellent route through which to administer drugs.

21 Aug 2006

Dual-mode nanoscale imaging yields new details of cellular events

To create drugs capable of targeting malignancies, scientists must first decode exactly how a cell or a group of cells communicates with other cells and reacts to a broad spectrum of complex biomolecules surrounding it.

21 Aug 2006

Targeted magnetic nanoparticles may be useful in both detecting and treating metastatic breast cancer

An in-depth study of nanoparticle distribution in tumor-bearing mice has shown that targeted magnetic nanoparticles accumulate and cluster in both primary breast tumors and metastatic lesions that have developed in the lung.

21 Aug 2006

St. John's wort and polymeric nanoparticles to treat ovarian tumors using light

By combining a compound produced by the plant St. John's wort with polymeric nanoparticles, researchers at the University of Geneva in Switzerland have developed a promising method for treating ovarian tumors using light.

21 Aug 2006

Formation of an internal FDA Nanotechnology Task Force

Acting Commissioner of Food and Drugs Andrew C. von Eschenbach, M.D., today announced the formation of an internal FDA Nanotechnology Task Force.

9 Aug 2006

DNA overwinds when stretched

Most of us are familiar with the winding staircase image of DNA, the repository of a biological cell's genetic information. But few of us realize just how tightly that famous double helix is wound.

8 Aug 2006

Heat treatment may zap cancer cells

Scientists believe they have discovered a clue as to why so many men with testicular cancer survive against the odds.

26 Jul 2006

Herceptin-linked nanoparticles for targeted cancer therapy

Albumin nanoparticles have recently proven their mettle as anticancer agents with the 2005 approval of Abraxane to treat metastatic breast cancer.

17 Jul 2006

Diblock copolymer micellar nanoparticles decorated with annexin-A5 proteins

One of the banes of modern cancer therapy is that clinicians and patients must often wait months before they can tell if a given treatment is working.

17 Jul 2006

Self-illuminating quantum dots for in vivo imaging

Quantum dots have already proven themselves as powerful imaging probes that can enable researchers to track disease-related molecules inside cells and even within the body.

17 Jul 2006

Scientists develop piezoresponse force microscopy

A seminal early event in the history of nanotechnology was the development of the atomic force microscope (AFM), which used a nanoscale cantilever to image solid materials at the atomic level.

17 Jul 2006

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells

Various types of carbon-based nanomaterials, such as buckyballs and nanotubes, have shown promise as drug delivery tools and imaging agents, but reports of toxicity associated with some of these materials have raised questions about their ultimate utility in clinical oncology.

10 Jul 2006

Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates

Using a synthetic peptide modeled after the protein that the human immunodeficiency virus (HIV) uses to enter cells, a multi-institutional research team has created quantum dots that can penetrate the cell membrane and image internal structures in a cell.

10 Jul 2006

Nanoscale metal-organic frameworks as potential multimodal contrast enhancing agents

By combining the properties of inorganic and organic molecules in one material, researchers at the Carolina Center of Cancer Nanotechnology Excellence (CCNE) have developed a new class of nanomaterials that can be used to create multifunctional nanoparticles.

10 Jul 2006

Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas

Most attempts to develop imaging agents that can better distinguish tumors from healthy tissue focus on finding molecules that are more abundant on malignant cells than on normal cells and using those as cellular targets.

10 Jul 2006

Nanotechnology News and Research

Quantum dot nanodevice that can detect and image apoptosis

Scientists develop magnetic nanoparticles for medicine

New method for attaching tumor-targeting antibodies to the surface of buckyballs

Targeted nanoparticles to improve Boron-Neutron capture therapy

New methods for screening nanoparticles and interaction with human cells

Investigation of the proinflammatory potential of biodegradable nanoparticle drug delivery systems in the lung

Dual-mode nanoscale imaging yields new details of cellular events

Targeted magnetic nanoparticles may be useful in both detecting and treating metastatic breast cancer

St. John's wort and polymeric nanoparticles to treat ovarian tumors using light

Formation of an internal FDA Nanotechnology Task Force

DNA overwinds when stretched

Heat treatment may zap cancer cells

Herceptin-linked nanoparticles for targeted cancer therapy

Diblock copolymer micellar nanoparticles decorated with annexin-A5 proteins

Self-illuminating quantum dots for in vivo imaging

Scientists develop piezoresponse force microscopy

Functionalized carbon nanotubes are non-cytotoxic and preserve the functionality of primary immune cells

Proteolytic activity monitored by fluorescence resonance energy transfer through quantum-dot-peptide conjugates

Nanoscale metal-organic frameworks as potential multimodal contrast enhancing agents

Imaging pancreatic cancer with a peptide-nanoparticle conjugate targeted to normal pancreas

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