OCT News and Research

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Researchers identify brain circuitry involved in emotional aspects of chronic pain

Negative emotional states and physical pain are intimately connected. Numerous people who suffer from chronic, persistent pain also deal with negative emotions and loss of motivation.

18 Oct 2021

Watch: Going beyond the script of ‘Dopesick’ and America’s real-life opioid crisis

KHN and policy colleagues at our parent organization KFF teamed up with Hulu for a discussion of America’s opioid crisis, following the Oct. 13 premiere of the online streaming service's new series "Dopesick."

18 Oct 2021

Three new genetic variants linked to fibromuscular dysplasia

Three new genetic variants that regulate gene expression in the arteries are connected to fibromuscular dysplasia, an arterial disease that can cause dangerous consequences for the heart and vessels, according to a new study.

18 Oct 2021

UC Davis researchers publish the first atlas of metabolites in the mouse brain

The first atlas of metabolites in the mouse brain has been published by a team led by UC Davis researchers.

18 Oct 2021

Researchers report long-lasting effects of gene therapy in children with deadly immune disorder

Over a decade ago, UCLA physician-scientists began using a pioneering gene therapy they developed to treat children born with a rare and deadly immune system disorder.

18 Oct 2021

Coronavirus vaccines and prior infections can provide broad immunity against similar viruses

Northwestern Medicine scientists have shown for the first time that coronavirus vaccines and prior coronavirus infections can provide broad immunity against other, similar coronaviruses. The findings build a rationale for universal coronavirus vaccines that could prove useful in the face of future epidemics.

18 Oct 2021

Scientists pave the way for creating 'mini biological computers' in droplets

Scientists have worked out how to best get DNA to communicate with membranes in our body, paving the way for the creation of 'mini biological computers' in droplets that have potential uses in biosensing and mRNA vaccines.

18 Oct 2021

Study provides the most detailed analysis of England's SARS-CoV-2 genomic surveillance information

The Covid-19 crisis that gripped the UK between September 2020 and June 2021 can be thought of as a series of overlapping epidemics, rather than a single event, say researchers at the Wellcome Sanger Institute, EMBL's European Bioinformatics Institute (EMBL-EBI) and their collaborators.

18 Oct 2021

New method to study the nuclear pore complex directly inside cells

Context matters. It's true for many facets of life, including the tiny molecular machines that perform vital functions inside our cells.

18 Oct 2021

Researchers discover a new paradigm for how biological switches are regulated

Quantitative Biosciences Institute (QBI) researchers at UC San Francisco have discovered a new paradigm for how fundamental biological switches, proteins that can be turned on and off to control processes like cell differentiation, cell growth, and transport within a cell, are regulated at the molecular level, specifically by molecules binding at newly discovered sites far away from the main binding site, and the broader impacts these changes have on a cellular level.

18 Oct 2021

People with obesity overrepresented among COVID-19 patients receiving intensive care

People with obesity were overrepresented among adults in Sweden receiving intensive care for COVID-19 during the first wave of the pandemic. Just over 39 percent had obesity, compared with some 16 percent in the population.

18 Oct 2021

Machine learning can yield "proxy measures" for brain-related health issues

A study published today by an interdisciplinary collaboration, directed by Denis Engemann from Inria, demonstrates that machine learning from large population cohorts can yield "proxy measures" for brain-related health issues without the need for a specialist's assessment.

18 Oct 2021

Research reveals how daily circadian rhythms help to change heart function

A new study has shown how circadian rhythms in heart cells help to change heart function over the course of the day and may explain why shift workers are more vulnerable to heart problems.

18 Oct 2021

Study finds connection between austerity measures and increased mortality in England

Central government austerity measures since 2010 are linked to tens of thousands more deaths than expected, finds research published in the online journal BMJ Open on the joint impact of social care, public health, and healthcare spends on death rates before and after 2010.

18 Oct 2021

Study explores the likelihood of inappropriate decisions by physicians during delivery

Clinical decisions made in the delivery setting as to whether to employ vaginal delivery or cesarean section are often made under high pressure, and with great uncertainty, and have serious consequences for mother and baby.

18 Oct 2021

Pandemic-related grief associated with lower levels of mother-infant bonding

The emotional connection between a mother and her newborn baby can lay the foundation for the child's development and the family's outcomes.

15 Oct 2021

Children with cerebral palsy benefit most from higher doses of CIMT therapy

Children with cerebral palsy can gain greater use of an impaired arm and hand with larger doses of Constraint-Induced Movement Therapy (CIMT) – without increasing stress for parents, according to a new study by researchers at Virginia Tech's Fralin Biomedical Research Institute at VTC, UVA Children's, The Ohio State University, and Nationwide Children's Hospital.

15 Oct 2021

AI-based technology rapidly identifies genetic causes of rare disorders with high accuracy

An artificial intelligence (AI)-based technology rapidly diagnoses rare disorders in critically ill children with high accuracy, according to a report by scientists from University of Utah Health and Fabric Genomics, collaborators on a study led by Rady Children's Hospital in San Diego.

15 Oct 2021

Novel method for rapid incidence estimation from SARS-CoV-2 genomes

Daily counts of new COVID-19 cases remain a basis for evaluating the state of the pandemic and are vital for making informed decisions on public interventions.

15 Oct 2021

AI algorithm accurately detects disease-causing variants in infants with rare diseases

Fabric Genomics and Rady Children's Institute for Genomic Medicine today announced the publication of a retrospective study in Genome Medicine showing that across six leading genomic centers and hospitals, researchers were able to detect more than 90% of disease-causing variants in infants with rare diseases using the Fabric GEM AI algorithm and whole-genome and whole-exome data from previously diagnosed newborns and rare disease patients at Rady Children's Hospital - San Diego and other clinical sites.

15 Oct 2021

OCT News and Research

Researchers identify brain circuitry involved in emotional aspects of chronic pain

Watch: Going beyond the script of ‘Dopesick’ and America’s real-life opioid crisis

Three new genetic variants linked to fibromuscular dysplasia

UC Davis researchers publish the first atlas of metabolites in the mouse brain

Researchers report long-lasting effects of gene therapy in children with deadly immune disorder

Coronavirus vaccines and prior infections can provide broad immunity against similar viruses

Scientists pave the way for creating 'mini biological computers' in droplets

Study provides the most detailed analysis of England's SARS-CoV-2 genomic surveillance information

New method to study the nuclear pore complex directly inside cells

Researchers discover a new paradigm for how biological switches are regulated

People with obesity overrepresented among COVID-19 patients receiving intensive care

Machine learning can yield "proxy measures" for brain-related health issues

Research reveals how daily circadian rhythms help to change heart function

Study finds connection between austerity measures and increased mortality in England

Study explores the likelihood of inappropriate decisions by physicians during delivery

Pandemic-related grief associated with lower levels of mother-infant bonding

Children with cerebral palsy benefit most from higher doses of CIMT therapy

AI-based technology rapidly identifies genetic causes of rare disorders with high accuracy

Novel method for rapid incidence estimation from SARS-CoV-2 genomes

AI algorithm accurately detects disease-causing variants in infants with rare diseases

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