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Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Removing an immunomodulatory protein called osteopontin improves the symptoms of mice with muscular dystrophy by changing the type of macrophages acting on damaged muscle tissue, according to a paper published in The Journal of Cell Biology.

19 Apr 2016

Study describes precise mechanisms that enable TB bacteria to persist in the body

Bacteria that cause tuberculosis trick immune cells meant to destroy them into hiding and feeding them instead. This is the result of a study led by researchers from NYU Langone Medical Center and published online April 18 in Nature Immunology.

19 Apr 2016

SBRT for prostate cancer treatment offers higher cure rate than many traditional approaches

A five-year study shows that Stereotactic Body Radiation Therapy (SBRT) to treat prostate cancer offers a higher cure rate than more traditional approaches, according to researchers at UT Southwestern Medical Center Harold C. Simmons Comprehensive Cancer Center.

19 Apr 2016

Cyclodextrin offers potential new therapy for cardiovascular disease

An American mother's hunch might result in new treatments for patients who can't tolerate conventional cholesterol-lowering drugs.

19 Apr 2016

Newly discovered player in epigenetic regulation closely linked to known cancer promoters

If genes form the body's blueprint, then the layer of epigenetics decides which parts of the plan get built. Unfortunately, many cancers hijack epigenetics to modulate the expression of genes, thus promoting cancer growth and survival.

19 Apr 2016

Researchers examine neuropsychological effect in ecstasy users

Researchers from the University of Liverpool have conducted a study examining the effect ecstasy has on different parts of the brain.

19 Apr 2016

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Asthma is an enormous public health problem that continues to grow larger, in part because scientists don't fully understand how it is caused. Existing therapies don't cure the disease and often don't even significantly alleviate the symptoms. Now, scientists from the Perelman School of Medicine at the University of Pennsylvania and Rutgers University have identified a biological pathway that potentially explains why current asthma therapies don't work well in many cases—and might be targeted to help those patients.

19 Apr 2016

Researchers find way to attack a process that tumor cells use to escape effects of cancer drugs

Cancer cells often devise ways to survive even in the presence of toxic chemotherapy. Now, a research team led by investigators at Beth Israel Deaconess Medical Center has found a way to attack a process that tumor cells use to escape the effects of standard cancer drugs. The discovery is published online today in the journal Nature Cell Biology.

19 Apr 2016

New computer algorithm can better characterize functional context of genomic variations in cancer

Cancer is rarely the result of a single mutation in a single gene. Rather, tumors arise from the complex interplay between any number of mutually exclusive abnormal changes in the genome, the combinations of which can be unique to each individual patient.

19 Apr 2016

Inhibiting adrenaline receptors reduces breast cancer brain metastases

While we look to invent new medicines to treat cancer, a parallel approach to repurpose existing medicines may be highly effective. Stress, mediated by adrenaline, has been suspected to promote cancer growth and this research study shows that by blocking adrenaline receptors in breast cancers, they are less successful in spreading to and growing in the brain.

19 Apr 2016

High dietary saturated fat intake may lead to prostate cancer aggressiveness

Eating a diet higher in saturated fat, a type of fat found commonly in foods such as fatty beef and cheese, was linked to more aggressive prostate cancer, a study by University of North Carolina Lineberger Comprehensive Cancer Center researchers and collaborators has found. The preliminary results were presented Monday, April 18 at the American Association for Cancer Research Annual Meeting in New Orleans.

19 Apr 2016

Researchers devise method to stably internalize chemotherapy loaded microparticles into prostate cells

A collaborative Brigham and Women's Hospital and Johns Hopkins University co-led team has found proof-of-concept evidence for a potential cancer treatment that leverages microparticles and mesenchymal stem cells.

19 Apr 2016

Study: British adults agree to donate heart, kidney and lungs, but not eyes for transplant

Despite a shortage of corneas for transplant purposes, new research reveals that eyes are the one body part we are least likely to donate.

19 Apr 2016

Reducing hair loss during chemotherapy: an interview with Richard Paxman

The basic principle of chemotherapy is to damage the mitotic and metabolic processes in the cancer cells. The chemotherapy doesn't just target the cancer cells, it also targets the healthy cells, specifically ones that are rapidly dividing - our hair follicles are also rapidly dividing. We see damage to those hair cells, which then causes the hair to fall out.

From Paxman 19 Apr 2016

Georgetown researchers report first case of Alzheimer's disease diagnosed in HIV-positive individual

Georgetown University researchers are reporting the first case of Alzheimer's disease diagnosed in an HIV-positive individual. The finding in a 71-year-old man triggers a realization about HIV survivors now reaching the age when Alzheimer's risk begins to escalate.

18 Apr 2016

Existing cancer drugs may be able to help people with enlarged heart cells

UT Southwestern Medical Center cardiology researchers have identified molecular ties between the growth of cancer cells and heart cells that suggest existing cancer drugs may be able to help those with enlarged heart cells -- a condition that can lead to heart attacks and stroke.

18 Apr 2016

Medi-551 antibody treatment decreases number of cancer stem cells by half in multiple myeloma patients

An experimental antibody treatment decreased by half the number of cancer stem cells that drive the growth of tumors in nearly all patients with multiple myeloma, a cancer of the bone marrow and bone tissue, according to results of a preliminary clinical trial led by Johns Hopkins Kimmel Cancer Center scientists.

18 Apr 2016

First-ever nivolumab drug trial for rare, malignant SCCA shows positive results

A rare malignancy known as squamous cell carcinoma of the anal canal (SCCA) is on the increase, and now researchers have reported results of the first-ever phase II clinical trial results for treatment with the immunotherapy drug nivolumab.

18 Apr 2016

Mouse model can help identify new, more effective melanoma-preventing agents

Application of sun protection factor 30 (SPF30) sunscreen prior to exposure to ultraviolet-B (UVB) light delayed melanoma onset in a mouse model of the disease, according to data from a team at The Ohio State University Comprehensive Cancer Center Comprehensive Cancer Center - Arthur G. James Cancer Hospital and Richard J. Solove Research Institute. This data suggest that the mouse model can be used to identify new, more effective melanoma-preventing agents, according to principal investigator Christin Burd, PhD.

18 Apr 2016

Scientists develop innovative technique to deliver cancer drugs deep into tumour cells

Scientists at Nanyang Technological University (NTU Singapore) have invented a new way to deliver cancer drugs deep into tumour cells.

18 Apr 2016

Drugs News and Research

Removing immunomodulatory protein improves symptoms of muscular dystrophy in mice

Study describes precise mechanisms that enable TB bacteria to persist in the body

SBRT for prostate cancer treatment offers higher cure rate than many traditional approaches

Cyclodextrin offers potential new therapy for cardiovascular disease

Newly discovered player in epigenetic regulation closely linked to known cancer promoters

Researchers examine neuropsychological effect in ecstasy users

Researchers identify biological pathway that explains why current asthma therapies fail in many cases

Researchers find way to attack a process that tumor cells use to escape effects of cancer drugs

New computer algorithm can better characterize functional context of genomic variations in cancer

Inhibiting adrenaline receptors reduces breast cancer brain metastases

High dietary saturated fat intake may lead to prostate cancer aggressiveness

Researchers devise method to stably internalize chemotherapy loaded microparticles into prostate cells

Study: British adults agree to donate heart, kidney and lungs, but not eyes for transplant

Reducing hair loss during chemotherapy: an interview with Richard Paxman

Georgetown researchers report first case of Alzheimer's disease diagnosed in HIV-positive individual

Existing cancer drugs may be able to help people with enlarged heart cells

Medi-551 antibody treatment decreases number of cancer stem cells by half in multiple myeloma patients

First-ever nivolumab drug trial for rare, malignant SCCA shows positive results

Mouse model can help identify new, more effective melanoma-preventing agents

Scientists develop innovative technique to deliver cancer drugs deep into tumour cells

Event guide: 4th Extra-Hepatic Lipid-Based Nanoparticles Delivery Summit eBook

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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