Acute Lymphoblastic Leukemia News and Research

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Acute lymphoblastic leukemia (ALL) is a cancer of the white blood cells, the cells in the body that normally fight infections. There are two main types of white blood cells-lymphoid cells and myeloid cells. ALL affects lymphoid cells.

Almost half of all childhood cancer cases go undiagnosed

A new study estimates that almost half of all children in the world who have cancer are not diagnosed or treated, leaving them to “die at home.”

27 Feb 2019

Killer T cells may explain inability of immune cells to destroy cancer tumors

Scientists at the University of Virginia School of Medicine have discovered a defect in immune cells known as "killer T cells" that explains their inability to destroy cancer tumors. The researchers believe that repairing this defect could make the cells much better cancer killers.

26 Feb 2019

Moffitt researchers shed light on how CAR T cells function mechanistically

The scientific community has made great strides over the past decade in the development of a new class of cancer therapy called immunotherapy, a treatment that activates a patient's own immune system to target cancer cells.

15 Feb 2019

Genetic variations in a fourth gene associated with higher ALL risk in Hispanic children

St. Jude Children's Research Hospital scientists have identified genetic variations in a fourth gene that are associated with an increased risk of acute lymphoblastic leukemia in Hispanic children. The research appears today in the journal Blood.

15 Feb 2019

Study: Prolonged presence of precursor cells in thymus may give rise to leukemia

Acute T-cell lymphoblastic leukemia is a rare type of blood cancer that affects mostly children. This blood cancer appears from the precursor cells that produce T lymphocytes.

28 Jan 2019

Researchers identify multiple new subtypes of most common childhood cancer

Like cartographers completing a map, investigators have identified multiple new subtypes of the most common childhood cancer--research that will likely improve the diagnosis and treatment of high-risk patients.

14 Jan 2019

Research reviews role of protein tyrosine phosphatase in molecular biology

As the proteomics technology develops and human genomic analysis becomes easier to execute, molecules involved in the regulation of biochemical signaling pathways have become interesting subjects for researchers.

28 Dec 2018

CHLA researcher reveals how leukemia burrows within the bone marrow

Actually, cancer can hide. A researcher at Children's Hospital Los Angeles tells us exactly how leukemia burrows within bone marrow, where it is shielded from chemotherapy treatments.

21 Dec 2018

Genetic marker, predictor of early relapse in common childhood cancer discovered

Nova Southeastern University researchers recently discovered that by testing the level of NER (nucleotide excision repair) gene expression, pediatric oncologists can determine the likelihood of early relapse (less than three years) in their acute lymphoblastic leukemia patients.

14 Dec 2018

Physician-scientists present updated efficacy data on CAR T-cell gene immunotherapy

Physician-scientists from Children's Hospital of Philadelphia presented updated efficacy and safety data on Kymriah--the first-ever U.S. Food and Drug Administration approved personalized CAR T-cell gene immunotherapy for aggressive blood cancers at the 60th American Society of Hematology annual meeting, as well as first-of-its-kind research on overcoming CAR T-cell resistance.

5 Dec 2018

New strategies may improve performance of CAR-T cell therapy in treating cancer

Mayo Clinic researchers have developed two new strategies that may improve the performance of chimeric antigen receptor therapy in treating cancer. They are presenting results of their preclinical research at the 2018 annual meeting of the American Society of Hematology in San Diego.

3 Dec 2018

Research highlights ability of Bio-Rad's ddPCR in quantifying minimal residual disease

More than 30 abstracts presented at the 60th American Society of Hematology Annual Meeting & Exposition in San Diego, December 1-4, featured research highlighting the ability of Bio-Rad's Droplet Digital PCR to provide high sensitivity and accuracy in quantifying minimal residual disease -- those remaining cancer cells after therapy that are associated with relapse -- in blood diseases such as leukemia.

3 Dec 2018

SSB enters into collaboration with Immunochina to develop new immunotherapy equipment

Sartorius Stedim Biotech, a leading international supplier of the biopharmaceutical industry, through its China affiliate, and Beijing-based Immunochina Pharmaceuticals, announced today that both parties have entered into a collaboration.

3 Dec 2018

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

In an update to a global clinical trial stretching from Philadelphia to four continents, the chimeric antigen receptor (CAR) T cell therapy Kymriah (tisagenlecleucel, formerly CTL019) led to long-lasting remissions in patients with relapsed/refractory (r/r) diffuse large B-cell lymphoma (DLBCL).

3 Dec 2018

Triple combination cancer immunotherapy improves survival in mouse model of melanoma

Adoptive cell transfer is a promising cancer immunotherapy that involves isolating T cells from cancer patients that are capable of targeting their tumor, selecting the more active T cells and expanding those in the lab, and then transfusing them back into patients.

30 Nov 2018

Abramson Cancer Center becomes the 28th member institution of National Comprehensive Cancer Network

The Abramson Cancer Center (ACC) at the University of Pennsylvania announced today that it is joining the National Comprehensive Cancer Network (NCCN) as its 28th member institution.

20 Nov 2018

St. Jude Hospital announces availability of largest collections of leukemia samples

St. Jude Children's Research Hospital today announced the availability of one of the world's largest collections of leukemia samples from children and adults.

15 Nov 2018

Amgen announces presentation of new clinical data showcasing early oncology pipeline at ASH 2018

Amgen today announced that new clinical data will be presented at the 60th American Society of Hematology Annual Meeting & Exposition in San Diego, Dec. 1-4, 2018. Data across an array of malignancies will be featured in 45 abstracts, including nine oral presentations, from the Company’s broad portfolio andearly-stage pipeline.

From AMGEN 5 Nov 2018

Why patients with ALL relapse after CAR-T cell therapy

Researchers have made a new discovery about a rare mechanism that triggers the relapse of acute lymphoblastic leukemia (ALL) after CAR T cell therapy.

1 Oct 2018

Why patients with ALL relapse after CAR-T cell therapy

Researchers have made a new discovery about a rare mechanism that triggers the relapse of acute lymphoblastic leukemia (ALL) after CAR T cell therapy.

1 Oct 2018

Acute Lymphoblastic Leukemia News and Research

Further Reading

Almost half of all childhood cancer cases go undiagnosed

Killer T cells may explain inability of immune cells to destroy cancer tumors

Moffitt researchers shed light on how CAR T cells function mechanistically

Genetic variations in a fourth gene associated with higher ALL risk in Hispanic children

Study: Prolonged presence of precursor cells in thymus may give rise to leukemia

Researchers identify multiple new subtypes of most common childhood cancer

Research reviews role of protein tyrosine phosphatase in molecular biology

CHLA researcher reveals how leukemia burrows within the bone marrow

Genetic marker, predictor of early relapse in common childhood cancer discovered

Physician-scientists present updated efficacy data on CAR T-cell gene immunotherapy

New strategies may improve performance of CAR-T cell therapy in treating cancer

Research highlights ability of Bio-Rad's ddPCR in quantifying minimal residual disease

SSB enters into collaboration with Immunochina to develop new immunotherapy equipment

CAR T therapy can lead to long-lasting remissions in patients with r/r diffuse large B-cell lymphoma

Triple combination cancer immunotherapy improves survival in mouse model of melanoma

Abramson Cancer Center becomes the 28th member institution of National Comprehensive Cancer Network

St. Jude Hospital announces availability of largest collections of leukemia samples

Amgen announces presentation of new clinical data showcasing early oncology pipeline at ASH 2018

Why patients with ALL relapse after CAR-T cell therapy

Why patients with ALL relapse after CAR-T cell therapy

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