Acute Respiratory Distress Syndrome News and Research

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Dexamethasone shown to upregulate innate and adaptive immune responses in COVID-19 acute respiratory distress syndrome patients

In a new study, researchers used per protocol bronchoalveolar lavage fluid (BALF) samples after intubation to evaluate the transcriptomic profiles of the local pulmonary host responses during early-stage severe coronavirus disease 2019 (COVID-19) acute respiratory distress syndrome (CARDS), non-COVID-19 ARDS, and sepsis.

17 Jan 2022

New model to identify biological markers in patients with COVID-19 and other illnesses

Investigators who recently developed a mathematical model that indicated why treatment responses vary widely among individuals with COVID-19 have now used the model to identify biological markers related to these different responses.

17 Jan 2022

Genome editing in vascular endothelial cells made possible with a powerful new delivery system

Northwestern Medicine scientists developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which line blood vessel walls.

16 Jan 2022

Microbial characteristics of COVID-19

To better understand how the disease progresses, a recent paper in the journal Frontiers in Medicine discusses the role of the human microbiota in this condition.

13 Jan 2022

Role of leptin in immune modulation and pathophysiology of COVID-19

A recent review paper in the journal Frontiers in Physiology discusses the role of leptins in infection with SARS-CoV-2 that triggered the ongoing COVID-19 pandemic.

13 Jan 2022

Addition of wound care nurse to prone-positioning team reduces the odds of pressure injuries in patients

The addition of a certified wound and skin care nurse to a multiprofessional prone-positioning team at Penn Medicine Princeton Health significantly reduced the odds of patients with COVID-19 developing pressure injuries, according to a study published in American Journal of Critical Care.

5 Jan 2022

Unique nanoparticle can deliver genome editing technology to endothelial cells

The lab of Youyang Zhao, PhD, from Stanley Manne Children's Research Institute at Ann & Robert H. Lurie Children's Hospital of Chicago developed a unique nanoparticle to deliver genome editing technology, including CRISPR/Cas9, to endothelial cells, which are cells that line blood vessel walls.

4 Jan 2022

SARS-CoV-2 omicron variant may be less severe than the delta variant

A new study reveals that omicron infections in South Africa are associated with lower rates of hospital admissions and lower disease severity compared to beta and delta infections.

31 Dec 2021

An integrated computational methodology for COVID drug prioritization

Researchers recently published a study in the journal Briefings in Bioinformatics wherein they integrated multiple bioinformatics and cheminformatics-based methods to prioritize drugs for the treatment of COVID-19.

29 Dec 2021

Booster dose of mRNA vaccines found crucial in protecting against SARS-CoV-2 Omicron variants

A new study shows that Omicron is more infectious than any of the other variants and that booster vaccines, especially mRNA vaccines, are capable of neutralizing Omicron variants of pseudoviruses.

29 Dec 2021

Double-dose mRNA COVID vaccines effective among dialysis patients

Researchers assess the impact of lesser initial vaccine response and subsequent waning antibody levels on clinical outcomes among maintenance dialysis.

28 Dec 2021

Structural blueprint of nanoparticles developed to target neutrophils responsible for acute lung inflammation

The COVID-19 pandemic highlighted the devastating impact of acute lung inflammation (ALI), which is part of the acute respiratory distress syndrome (ARDS) that is the dominant cause of death in COVID-19.

28 Dec 2021

Exploring the Mediterranean diet as a potential strategy against SARS-CoV-2

A study found that the Mediterranean diet, when combined with non-smoking and regular physical activity, can lower susceptibility to SARS-CoV-2.

22 Dec 2021

Understanding SARS-CoV-2-induced systemic amyloidosis

A new study proposed that inflammation combined with aggregates of amyloidogenic peptides of SARS-CoV-2 S proteins might induce systemic amyloidosis.

21 Dec 2021

Study shows risk of long-term impact of COVID-19 on patients with cardiovascular diseases and diabetes mellitus

British researchers analyze the net effect of COVID-19 on cardiometabolic outcomes over one month, three months, and twelve months.

19 Dec 2021

Study suggests 2/3 of Dutch children < 12 years have been infected with SARS-CoV-2

Researchers conduct intensive and longitudinal monitoring of households with children of different ages for the presence of SARS-CoV-2.

19 Dec 2021

Hyperbaric oxygen treatment quickly resolves severe breathing difficulties in COVID-19 patients

High pressure (hyperbaric) oxygen resolves severe breathing difficulties in COVID-19 patients much more quickly than standard therapy, taking an average of 3 rather than 9 days, reveal the results of a small comparative clinical trial published online in Emergency Medicine Journal.

15 Dec 2021

Containing a Nipah virus outbreak amidst the COVID-19 pandemic

A new study deals with a single case of Nipah virus that occurred in 2021, with no discoverable chain of transmission, apparently ending with the death of the index patient in Kerala.

15 Dec 2021

Frequent cognitive impairments after 4-month follow-up in ICU COVID-19 patients

Results from a recent observational study published in the Journal Of The Neurological Sciences found that after a 4-month follow-up, ICU patients with severe COVID-19 illness were more likely to have mild cognitive impairment with features related to a diffuse encephalopathy than patients with mild infection who do not need a ventilator. Additionally, ICU patients experienced more significant impairment in executive function. All neurological deficits involve the peripheral nervous system.

14 Dec 2021

Sarcopenia and COVID-19

The present study attempts to investigate if sarcopenia, which is a condition where there is loss of skeletal muscle mass and function, may result in poor clinical outcomes in COVID-19 patients.

13 Dec 2021