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New mouse model for ovarian cancer

A new University of Michigan Medical School study sheds light on cell defects that lead to one common type of ovarian cancer and puts forth a promising new mouse model that already is being used for preclinical drug testing.

12 Apr 2007

Time, therapy spur recovery from sudden sensorineural hearing loss

A first-of-its-kind study into time-dependent treatments of sudden sensorineural hearing loss published in the February 2007 issue of Otolaryngology- Head and Neck Surgery has determined that a combination of time and oral corticosteroid therapy can play a key role in helping patients regain full hearing, often within a month of the initial loss of hearing.

29 Jan 2007

Self-assembling nanoparticle releases drug into cell cytoplasm

A growing body of research leaves no doubt that nanoparticles can transport drugs into cancer cells, but what is less clear is that the drug payload can exit the tiny endosomes that pull nanoparticles into cells.

30 Oct 2006

Closing in on lethal arrhythmogenic right ventricular dysplasia in young athletes

Johns Hopkins experts on the genetics of a potentially lethal heart rhythm defect that runs in families and targets young athletes report they have greatly narrowed the hunt for the specific genetic mutations that contribute to the problem.

7 Sep 2006

Hormones may affect how brain listens

From zebra fish to humans, reproductive hormones govern behavioral responses to courtship signals.

3 May 2006

Fibroblast research could lead to alternatives to implanted electronic pacemakers

In guinea pig experiments, Johns Hopkins scientists fused common connective tissue cells taken from lungs with heart muscle cells to create a safe and effective biological pacemaker whose cells can fire on their own and naturally regulate the muscle's rhythmic beat.

5 Dec 2005

Study provides first steps toward individualized treatment of serious injuries

A multi-institutional research collaborative has begun to decipher the complex interplay of genes that underlies the body's response to major injuries.

1 Sep 2005

Anti-cancer antibodies produced in chickens

A team of researchers have produced the first fully functional, human sequence monoclonal antibodies (mAbs) in chickens.

29 Aug 2005

Simple blood test can quickly identify type of congestive heart failure

A simple blood test can quickly identify what type of congestive heart failure (CHF) a patient has, improving diagnostic accuracy; eliminating the need for extensive diagnostic tests, such as heart muscle biopsy or exploratory surgery; and enabling the patient to be treated sooner, according to a study published in the June 7 Journal of the American College of Cardiology.

6 Jun 2005

Crucial to develop set of protections for women who donate eggs to stem cell research

Now that stem cell researchers have devised an efficient way of creating new human embryonic stem cell lines, biomedical ethicists at the Stanford University School of Medicine say it's crucial to develop a unique set of protections for the women who donate their eggs to make the research possible.

20 May 2005

Researchers generate patient-specific stem cells

Researchers have isolated the first human embryonic stem cell lines specifically tailored to match the nuclear DNA of patients, both males and females of various ages, suffering from disease or spinal cord injury.

20 May 2005

Brain region recovery possible in former methamphetamine users

Adaptive changes in chemical activity in certain regions of the brain of former methamphetamine users who have not used the drug for a year or more suggest some recovery of neuronal structure and function, according to an article in the April issue of Archives of General Psychiatry.

4 Apr 2005

KCP protein protects kidneys from damage caused by chronic renal disease and injury

University of Michigan scientists have identified a new and unusual protein that reduces, in laboratory mice, kidney damage caused by chronic renal disease and acute toxic injuries.

28 Mar 2005

Patients with chronic fatigue syndrome respond to placebos at a lower rate

Contrary to conventional wisdom, patients with chronic fatigue syndrome respond to placebos at a lower rate than people with many other illnesses, according to the first systematic review of the topic.

22 Mar 2005

Mountaineering doctors hike medicine to new heights with Xtreme Everest

Doctors working at the edge of extreme are set to climb the world’s tallest mountain to look death in the face – and take its pulse. The medical research team will make the first ever measurements of blood oxygen in the ‘death zone’, at altitudes above 8,000 metres where the human body has struggled - and frequently failed - to survive.

16 Mar 2005

Diabetes Busting Burgers!

Chemists with the U.S. Department of Agriculture recently presented a preliminary report to the 229th national meeting of the American Chemical Society, in which they say they have discovered a form of soluble cellulose that, if added to high-fat food. The new finding could soon benefit people who regularly eat fast-foods that are high in fat.

16 Mar 2005

Scientists have regenerated a damaged optic nerve

This achievement, which occurred in laboratory mice and is described in the March 1, 2005 issue of the Journal of Cell Science, holds great promise for victims of diseases that destroy the optic nerve, and for sufferers of central nervous system injuries.

24 Feb 2005

Gene protects against environmental pollutants and pulmonary emphysema

Researchers at the Johns Hopkins Bloomberg School of Public Health and other institutions have identified a “master gene” in mice that controls the action of 50 other genes whose products protect the lungs against environmental pollutants.

17 Nov 2004

Researchers find effective treatment for Unusual Fever Syndrome caused by cold exposure

Remember when Grandma used to say, "don’t go out in the cold; you’ll get sick”? It turns out that she was right for a small number of people who have a condition called familial cold autoinflammatory syndrome (FCAS)

16 Nov 2004

Sirolimus drug-coated stent causes less inflammation than bare metal stents

In the treatment of coronary artery disease, a sirolimus drug-coated stent causes less inflammation than bare metal stents, according to preliminary research presented at the American Heart Association annual meeting by Loyola University Health System, Maywood, Ill.

11 Nov 2004