Cadherin News and Research

RSS

Promoter hypermethylation is common in breast cancer

Cancer epidemiologists at the University at Buffalo have identified specific genes that are most likely to become cancer promoters when exposed to a process called DNA promoter hypermethylation.

17 May 2007

Primary tumors can chose different strategies to spread and form metastases

Primary tumors can spread towards distant organs as single cells, when they lose a protein called E-cadherin.

16 May 2007

Specific genes identified that are most likely to become cancer promoters when exposed to DNA promoter hypermethylation

Hypermethylation is a process that causes genes that promote normal cell growth to produce proteins that cause malignant behavior, or unregulated cell growth. Until now, data has been very limited regarding the mechanism and causes of hypermethylation, especially for hypermethylation in breast cancer.

15 May 2007

Leptin shown to significantly influence breast cancer development

Being obese increases the risk of breast cancer in post-menopausal women, shortens the time between return of the disease and lowers overall survival rates.

30 Apr 2007

KCI investigators present research findings on breast cancer-causing genes

Members from the laboratory of Stephen Ethier, Ph.D., deputy center director and director of basic science for the Barbara Ann Karmanos Cancer Institute, will present research findings on breast cancer-causing genes and how they operate at the American Association of Cancer Research Annual Meeting, April 13-18, in Los Angeles, CA.

16 Apr 2007

Researchers identify 221 genes possibly related to addiction vulnerability

Scientists supported by the National Institute on Drug Abuse (NIDA), part of the National Institutes of Health, have for the first time identified genes that might increase a person's ability to abstain from smoking.

4 Apr 2007

Breakthrough research finds genes which may help smoking cessation

2 Apr 2007

p120 catenin protein can stop metastasis or promote it

A protein known to be a key component of the glue that holds cells together also is involved in breaking them apart and promoting their movement when tumors begin to spread to other parts of the body, researchers at Mayo Clinic have found.

20 Sep 2006

Cathepsin inhibitors as cancer therapies

In the March 1 issue, Drs. Johanna Joyce (MSKCC), Douglas Hanahan (UCSF) and colleagues lend new insight into how broad-spectrum cysteine cathepsin inhibitors combat pancreatic cancer, and provide new data to help refine the design of more precisely targeted anti-cathepsin therapies.

17 Feb 2006

Genetics of human muscular dystrophy

Various forms of human muscular dystrophy result from mutations in genes encoding proteins of the nuclear envelope. A new paper in the February 15th issue of G&D reveals how.

17 Feb 2006

E-cadherin, that cellular touch so important in cancer

E-cadherin is a molecule involved in adhesion between epithelial cells that also seems to have a protective role in cancer, since its loss is associated with tumour progression and metastases formation in a series of different cancers.

16 Oct 2005

New data demonstrates how CA4P has anti-tumor and anti-angiogenic activity

Anti-angiogenic agents have been successful in the clinic for blocking the growth of solid tumors. However, these agents used in combination with chemotherapy have improved the survival of patients with cancers by only several months.

9 Oct 2005

Asymmetric cell divisions are essential for skin development

It took almost 10 years for Elaine Fuchs, Ph.D., a Howard Hughes Medical Institute investigator at Rockefeller University, to find a postdoctoral fellow who shared her curiosity for the direction of cell divisions in the skin.

18 Aug 2005

Potential new treatment strategy against metastatic cancer cells

A team of scientists at The Scripps Research Institute has identified a potential treatment strategy against metastatic cancer cells that has never been tried before.

25 Oct 2004

Discovery of key molecular step which allows cancer cells to move to different parts of the body

Researchers at The University of Texas M. D. Anderson Cancer Center have figured out a key molecular step by which a cancer cell can unhook itself from the mesh weave of other cancer cells in a tumor, and move away to a different part of the body - the process, known as metastasis, that makes cancer so dangerous.

27 Sep 2004

Discovery of molecule that is part of the machinery that mediates the sense of hearing

A group of scientists at The Scripps Research Institute, at the University of California in San Diego, and at the Oregon Hearing Research Center and Vollum Institute at Oregon Health & Science University have discovered a key molecule that is part of the machinery that mediates the sense of hearing.

28 Mar 2004

New treatment for heart attacks

A team led by scientists at The Scripps Research Institute has developed a potential new treatment for heart attacks. The therapy inhibits fluid leakage from cardiac blood vessels following a heart attack and thereby significantly prevents long-term heart damage and improves survival.

22 Mar 2004