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Expanded DepMap reveals new cancer vulnerabilities through 3D tumor models

For nearly a decade, the Cancer Dependency Map, or DepMap, at the Broad Institute has helped scientists uncover new cancer dependencies - the genetic changes some cancers need to thrive that can potentially be targeted by new cancer drugs.

5 Aug 2026

HMGCR emerges as a promising target for precision cancer therapies

A growing body of evidence is reshaping how scientists and clinicians understand the role of cancer metabolism, placing the enzyme HMGCR at the center of a rapidly evolving therapeutic landscape.

5 Aug 2026

Novel drug puts cancer cells under extreme metabolic stress

Cancer cells have a voracious appetite for sugar-using it to fuel their rapid growth. This is why many scientists have tried to develop drugs that block cancer cells' metabolism by cutting off their sugar supply.

5 Aug 2026

Newly discovered immune pathway prevents fatal fungal infections in mice

An immune pathway has been discovered which prevents a normally harmless fungus developing into a fatal infection.

5 Aug 2026

Tadalafil may increase glaucoma risk in men with enlarged prostates

An erectile dysfunction drug that is also used to treat symptoms like sudden urgency and frequency, which are associated with an enlarged prostate in men, may heighten the risk of the serious eye condition, glaucoma, finds a large comparative study published online in the British Journal of Ophthalmology.

4 Aug 2026

Malaria infection causes permanent damage to the spleen immune cells

Macrophages formed in the bone marrow can only assume the function of embryonal phagocytes, or "scavenger cells," to a certain degree according to a study by the University of Bonn and the Peter Doherty Institute for Infection and Immunity at the University of Melbourne.

4 Aug 2026

Cryo-EM study reveals dynamic structure of human norovirus

Human norovirus is the leading cause of acute gastroenteritis worldwide and is estimated to infect 600–700 million people each year.

4 Aug 2026

New 3D brain tissue model accelerates Alzheimer's drug development

How can Alzheimer's research be made faster, better, and more effective? After decades of intensive research worldwide and despite recent therapeutic advances, scientists have not managed to fully arrest the progress of the disease.

4 Aug 2026

Food may taste different on GLP-1 drugs, but taste may not be the reason

The review suggests that patient-reported “taste changes” during GLP-1RA treatment may reflect reduced food enjoyment and motivation rather than consistent impairment of basic taste. The authors propose a sensory-liking-wanting framework while emphasizing that current human evidence remains heterogeneous and largely indirect.

4 Aug 2026

'Me-too' drugs drive increased spending through higher prescribing

A long-running debate over prescription drug costs has centered on whether drug manufacturers are better rewarded for truly innovative medicines or so-called "me-too" drugs that may offer only incremental improvements over existing treatments but still command high prices.

3 Aug 2026

UCLA researchers find strategy to improve prostate cancer therapies

UCLA researchers have identified a promising strategy to make a new class of targeted cancer therapies more effective against one of the deadliest forms of prostate cancer, potentially overcoming treatment resistance that has limited their success.

3 Aug 2026

Five large corporations dominate Medicaid mental health care for adolescents

The United States is in the middle of a well-documented adolescent mental health crisis. Because Medicaid provides medical coverage for roughly half of all children in the country, the program has an essential role in responding to that crisis.

3 Aug 2026

RNA-based therapeutic strategy targets brain pathway behind cancer-associated cachexia

A new path has opened toward stopping cancer-associated cachexia, a devastating complication that gradually wastes patients away.

2 Aug 2026

Immune cell changes provide new insights into long COVID

Extreme fatigue, a racing pulse, shortness of breath, brain fog, aching joints-the symptoms of long COVID can vary widely, change unpredictably, and be difficult to even recognize as signs of the condition.

2 Aug 2026

New discovery advances sustainable production of plant-based medicines

Two plants that cause neurotoxicity and paralysis in the tiniest doses are also known to counter pain, malaria, cancer and pests.

31 Jul 2026

Ketamine boosts neuroplasticity through microglia in female brains

Doctors use ketamine on patients as general anesthesia before surgery. They also prescribe it in low doses for pain management, and more recently, it's been used for treatment-resistant depression where other drugs have failed.

31 Jul 2026

Study offers a potential strategy to make nanoparticle-based cancer drugs more effective

A new study led by researchers at The University of Texas MD Anderson Cancer Center has identified a way to reshape the gut microbiome that can enhance the delivery of certain chemotherapies to tumors, offering a potential strategy to make nanoparticle-based cancer drugs more effective.

31 Jul 2026