Pathophysiology News and Research

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Self-directed autoantibodies against certain chemokines may protect against long-COVID

A recent study published in the journal Nature Immunology discovered autoantibodies against chemokines following severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection.

8 Mar 2023

Analysis reveals an increasing trend in incidence of youth-onset type 1 and type 2 diabetes

New findings from researchers at Wake Forest University School of Medicine confirm that the rates of Type 1 and Type 2 diabetes continue to increase in children and young adults. Non-Hispanic Black and Hispanic children and young adults also had higher incidence rates of diabetes.

6 Mar 2023

Women’s heart disease pioneer receives the 2023 Master of the ACC Award

Noel Bairey Merz, MD, professor of cardiology and the director of the Barbra Streisand Women's Heart Center in the Smidt Heart Institute, will receive the 2023 Master of the ACC Award from the American College of Cardiology in honor of her pioneering contributions to the cardiovascular profession.

3 Mar 2023

Study identifies the essential genetic and immunologic perturbations occurring in patients with long COVID lung fibrosis

Researchers elucidated immunologic and genetic perturbations in long COVID patients with pulmonary fibrosis.

3 Mar 2023

Study identifies renalase as a novel independent predictor of COVID-19-related mortality

Researchers assessed the role of renalase as an independent predictor of COVID-19-related mortality.

2 Mar 2023

Role of phosphatidylinositol 3 kinase pathway in corneal damage due to blue light exposure

Researchers observe corneal damage by blue light exposure is due to PI3K/AKT pathway inhibition.

1 Mar 2023

Researchers use spatial single-cell transcriptome technique to examine immune signatures of SARS-CoV-2-infected lungs

The study findings demonstrate the power of spatial single-cell transcriptomics in studying COVID-19 lung pathology and other health and disease conditions.

1 Mar 2023

Study reveals synergistic impact of estrogen and intestinal dysbiosis on pulmonary fibrosis

In a recent study published in Cells, researchers evaluated idiopathic pulmonary fibrosis (IPF) pathophysiological differences by sex and intestinal microbiome.

1 Mar 2023

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

In a recent review published in Biomedicines, researchers explored extracellular vesicles (EVs), cell-penetrating peptides (CPPs), and micro ribonucleic acids (miRNAs) as therapies for neurodegenerative diseases such as Alzheimer’s disease (AD) and Parkinson’s disease (PD).

1 Mar 2023

An overview of the anti-inflammatory effects of nuts

Researchers summarize existing literature on the effects of consuming nuts on biomarkers of inflammation and oxidative stress.

28 Feb 2023

Natural product with grape seed extracts, lactic acid, and pea protein could effectively manage bacterial vaginosis

Researchers evaluate the efficacy of using a product comprising lactic acid, grape seed extract, and pea protein in managing bacterial vaginosis in vivo.

28 Feb 2023

Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall

Researchers assessed T-cell tolerance checkpoints observed in atherosclerosis.

27 Feb 2023

Study establishes new pre-clinical model to develop clinically relevant treatments for heart attacks

CÚRAM SFI Research Centre for Medical Devices researchers have published in Nature Communications a key study establishing a new pre-clinical model to develop clinically relevant treatments for heart attacks.

24 Feb 2023

Apolipoprotein E4 promotes the development of Alzheimer’s disease

Researchers characterize the effects of neuronal apolipoprotein E4 on Alzheimer’s disease-associated pathology.

23 Feb 2023

A growing burden of alcoholic hepatitis

A recent study published in the journal Medical Clinics of North America discussed the diagnosis, treatment, and pathophysiology of alcoholic hepatitis (AH).

21 Feb 2023

Research looks to determine prevalence of organ impairment in long-COVID patients

In a recent study published in the Journal of the Royal Society of Medicine, researchers assessed the association of long coronavirus disease (COVID) with multiple organ dysfunction.

16 Feb 2023

Delayed presentation of MIS-C following COVID-19

Researchers elucidate the pathophysiology of MIS-C and describe the probable reasons for the delayed presentation of the condition following COVID-19.

15 Feb 2023

New insights into the role of T-cells during long COVID

Researchers characterize the trajectory of long COVID in patients eight months after recovering from infection.

14 Feb 2023

Neuroprotectant linked to reduced death and disability among stroke patients

The neuroprotectant ApTOLL, a medication that may shield the brain from tissue damage, was linked to reduced death and disability among people being treated for stroke when used with standard treatments to restore blood flow, according to preliminary late-breaking science presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

Using blood pressure medications after endovascular treatment for stroke may not be safe or effective

Using blood pressure medications to lower the top number of blood pressure reading (systolic blood pressure) may not be safe or effective among people who have an acute ischemic stroke and undergo a successful mechanical clot removal — endovascular therapy, according to a phase-2 late-breaking clinical trial presented today at the American Stroke Association's International Stroke Conference 2023.

13 Feb 2023

Pathophysiology News and Research

Self-directed autoantibodies against certain chemokines may protect against long-COVID

Analysis reveals an increasing trend in incidence of youth-onset type 1 and type 2 diabetes

Women’s heart disease pioneer receives the 2023 Master of the ACC Award

Study identifies the essential genetic and immunologic perturbations occurring in patients with long COVID lung fibrosis

Study identifies renalase as a novel independent predictor of COVID-19-related mortality

Role of phosphatidylinositol 3 kinase pathway in corneal damage due to blue light exposure

Researchers use spatial single-cell transcriptome technique to examine immune signatures of SARS-CoV-2-infected lungs

Study reveals synergistic impact of estrogen and intestinal dysbiosis on pulmonary fibrosis

Exploring the neuroprotective potential of cell-penetrating peptides, extracellular vesicles, and micro ribonucleic acids

An overview of the anti-inflammatory effects of nuts

Natural product with grape seed extracts, lactic acid, and pea protein could effectively manage bacterial vaginosis

Study supports the concept of atherosclerosis as a T-cell autoimmune disease targeting the arterial wall

Study establishes new pre-clinical model to develop clinically relevant treatments for heart attacks

Apolipoprotein E4 promotes the development of Alzheimer’s disease

A growing burden of alcoholic hepatitis

Research looks to determine prevalence of organ impairment in long-COVID patients

Delayed presentation of MIS-C following COVID-19

New insights into the role of T-cells during long COVID

Neuroprotectant linked to reduced death and disability among stroke patients

Using blood pressure medications after endovascular treatment for stroke may not be safe or effective

Why use light scattering to analyze proteins and viral vectors?

Changing the landscape of R&D to build clinical success from the ground up

Sensing a Healthier Future

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