Spleen News and Research

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Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

In a recent study posted to the bioRxiv* preprint server, researchers evaluated responses of natural killer (NK) lymphocytes to VACV (vaccinia virus) infections in vivo.

16 Nov 2022

What is the role of macrophage origin, function, and heterogeneity in health and disease?

In a new study, researchers examined the wealth of information available regarding the heterogeneity of tissue macrophages.

14 Nov 2022

Novel branched ionizable lipid greatly increases the efficiency of mRNA delivery

Messenger RNA (mRNA) are biological molecules that transfer the information coded by genes in the nucleus to the cytoplasm for protein synthesis by ribosomes.

10 Nov 2022

Pioneering research identifies a promising treatment approach for myelofibrosis

Pioneering research into the chronic inflammation often seen in certain blood cancers has identified a promising treatment approach for myelofibrosis, a potentially deadly bone marrow cancer.

9 Nov 2022

Fermented dairy products can improve gut mucosal immunity

In a recent study published in the journal Immunology Letters, researchers assessed the role of fermented dairy products and dairy starters in modulating gut mucosal immunity.

3 Nov 2022

Avian influenza virus introduced from Europe to North America through Iceland

A new study indicated that Iceland was the stepping stone for the translocation of the highly pathogenic avian influenza virus (HPAIV) between North America and Europe.

25 Oct 2022

Newly identified brain molecule orchestrates the immune system's responses to Alzheimer's and MS

UVA Health researchers have discovered a molecule in the brain responsible for orchestrating the immune system's responses to Alzheimer's disease and multiple sclerosis (MS), potentially allowing doctors to supercharge the body's ability to fight those and other devastating neurological diseases.

17 Oct 2022

Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2

In a new study, researchers outlined the synthesis and the possible mechanism of action (MOA) of two potential severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) repurposing drug candidates.

17 Oct 2022

Did the diagnosis and management of Hodgkin lymphoma differ during the SARS-CoV-2 pandemic?

In a new study, researchers evaluated the impact of the SARS-CoV-2 pandemic on the diagnosis and treatment of classical Hodgkin lymphoma (cHL) patients in Istanbul, Turkey.

17 Oct 2022

Study provides new insights into the origin and development of B cells

B cells and the antibodies they produce play an important role in our immune system, protecting us from the microscopic enemies that make us ill.

11 Oct 2022

Study evaluates efficacy of a candidate SARS-CoV-2 subunit vaccine to protect endangered black-footed-ferrets

In a new study, researchers assessed the safety, efficacy, and immunogenicity of a candidate SARS-CoV-2 subunit vaccine in black-footed ferrets (BFF), and investigated the susceptibility of these endangered North American mammals to the virus.

7 Oct 2022

UAB study finds distinct kidney resident macrophage subpopulations located in spatially discrete microenvironments

Macrophages are immune cells that engulf and digest pathogens, cancer cells or cellular debris. The kidneys - like other tissues in the body - contain kidney resident macrophages, or KRMs, from the time of birth.

28 Sep 2022

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

In a recent study posted to the bioRxiv* preprint server, researchers in the United States assessed the role of two cytokines, interferon-gamma (IFN-γ) and interleukin-10 (IL-10), in regulating immune cell responses and inflammation early during severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection in rhesus macaques.

18 Sep 2022

Intranasal administration of liposomes displaying SARS-CoV-2 antigen induces mucosal immunity

A new study suggested that an intranasal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccine induced mucosal immune responses in mice.

14 Sep 2022

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

In a recent study published in the journal eBioMedicine, researchers in Denmark and Sweden administered a cationic liposome-adjuvanted severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike (S) protein subunit vaccine as a subcutaneous (s.c.) prime-intranasal (i.n.) boost strategy to elicit mucosal immune responses among SARS-CoV-2-infected Syrian hamsters.

14 Sep 2022

Mucosal vaccination triggers superior T cell response against SARS-CoV-2 variants

In a recent study posted to the bioRxiv* server, researchers in Singapore and the United States demonstrated that intranasal (I.N.) delivery of a mucosal severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccination triggered a superior T cell response compared to an equivalent dose of antigen delivered by the subcutaneous (S.C.) route.

12 Sep 2022

St. Baldrick's Scholar grant awarded to CU researcher for investigating new drug to treat infant leukemia

As part of its ongoing efforts to eradicate childhood cancers, the St. Baldrick's Foundation has awarded University of Colorado Cancer Center member Kelly Faulk, MD, a St. Baldrick's Scholar grant to investigate a new method for treating infant leukemia.

9 Sep 2022

Scientists identify genetic variants linked to an increased risk of developing Hodgkin lymphoma

Why did my child get cancer? Clinicians have longed for a way to help answer this question. Doctors knew Hodgkin lymphoma sometimes occurs in families, but why this happens has been a mystery. Scientists at St. Jude Children's Research Hospital have now helped solve it.

9 Sep 2022

Case report describes clinical manifestation of monkeypox, SARS-CoV-2, and HIV coinfection

Scientists have recently presented the first documented case of coinfection with monkeypox virus, SARS-CoV-2, and HIV.

23 Aug 2022

Insights into the biology of the monkeypox virus

Researchers provided insights into monkeypox virus structural characteristics, epidemiology, transmission, zoonotic reservoirs, pathogenesis, and clinical management.

23 Aug 2022

Spleen News and Research

Study of natural killer lymphocytes transcriptionally reprogrammed by vaccinia virus

What is the role of macrophage origin, function, and heterogeneity in health and disease?

Novel branched ionizable lipid greatly increases the efficiency of mRNA delivery

Pioneering research identifies a promising treatment approach for myelofibrosis

Fermented dairy products can improve gut mucosal immunity

Avian influenza virus introduced from Europe to North America through Iceland

Newly identified brain molecule orchestrates the immune system's responses to Alzheimer's and MS

Study reviews hydroxychloroquine and remdesivir antiviral potency against SARS‐CoV‐2

Did the diagnosis and management of Hodgkin lymphoma differ during the SARS-CoV-2 pandemic?

Study provides new insights into the origin and development of B cells

Study evaluates efficacy of a candidate SARS-CoV-2 subunit vaccine to protect endangered black-footed-ferrets

UAB study finds distinct kidney resident macrophage subpopulations located in spatially discrete microenvironments

Research examines the roles of cytokines during SARS-CoV-2 infection in rhesus macaques

Intranasal administration of liposomes displaying SARS-CoV-2 antigen induces mucosal immunity

Parenteral-prime mucosal boost an effective strategy to protect against SARS-CoV-2

Mucosal vaccination triggers superior T cell response against SARS-CoV-2 variants

St. Baldrick's Scholar grant awarded to CU researcher for investigating new drug to treat infant leukemia

Scientists identify genetic variants linked to an increased risk of developing Hodgkin lymphoma

Case report describes clinical manifestation of monkeypox, SARS-CoV-2, and HIV coinfection

Insights into the biology of the monkeypox virus

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

Expanding access to NMR with the Fourier 80 Duo

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