Clinical Trial News and Research

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Empowering older adults: Wearable tech made easier with personalized support

A new review in the Journal of Medical Internet Research, published by JMIR Publications, found that community-dwelling older adults are more likely to continue using wearable monitoring devices (WMDs), like trackers, pedometers, and smartwatches, if they receive support from health care professionals or peers.

21 Jun 2024

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Insilico Medicine ("Insilico"), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, announces that the co-CEOs of the company – Alex Zhavoronkov, PhD, and Feng Ren, PhD – will be attending the 15th Annual Meeting of the New Champions, also known as Summer Davos hosted by the World Economic Forum, in Dalian, China, from 25 to 27 June 2024.

21 Jun 2024

Anakinra shows promise in reducing symptoms in patients with Sanfilippo syndrome

As a neurodegenerative disease characterized by childhood onset dementia, Sanfilippo syndrome causes immense suffering in many ways, including pain, loss of speech, extreme agitation, and distress, gastrointestinal symptoms, and profound sleep disturbance.

21 Jun 2024

Repurposing anti-retroviral medications for brain tumor treatment: The RETREAT trial

Drugs developed to combat HIV and AIDS are being trialed for the first time in patients with multiple brain tumors.

21 Jun 2024

GLP-1 agonists linked to reduced dementia risk in type 2 diabetes patients

People with type 2 diabetes who are treated with GLP-1 agonists have a decreased risk of developing dementia, according to a new study from Karolinska Institutet in Sweden published in the journal eClinicalMedicine.

20 Jun 2024

Combining JAK inhibitors with checkpoint inhibitors improves cancer immunotherapy response

Because not all cancer patients respond to a leading type of cancer immunotherapy drug, known as an immune checkpoint inhibitor, scientists explored whether adding janus kinase (JAK) inhibitors – drugs that treat chronic inflammation – could help.

20 Jun 2024

Role of SMIM1 gene in obesity uncovered

Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese.

20 Jun 2024

JAK inhibitor ruxolitinib enhances immunotherapy in Hodgkin lymphoma patients

Checkpoint inhibitor therapies can be thought of as the molecular "brake release" for the immune system.

20 Jun 2024

Walking reduces recurrence of low back pain, study finds

Adults with a history of low back pain went nearly twice as long without a recurrence of their back pain if they walked regularly, a world-first study has found.

20 Jun 2024

Non-chemotherapy treatment regimen achieves full remission in aggressive B-cell lymphoma

Researchers at the National Institutes of Health (NIH) have developed a non-chemotherapy treatment regimen that is achieving full remissions for some people with aggressive B-cell lymphoma that has come back or is no longer responding to standard treatments.

19 Jun 2024

FDA approves a clinical trial to test the effectiveness of new brain sensor array

The Federal Drug Administration approved a clinical trial to test the effectiveness of an electronic grid that records brain activity during surgery, developed by engineers at the University of California San Diego.

19 Jun 2024

Improving stroke survivor health outcomes through home safety interventions

Researchers at Washington University School of Medicine in St. Louis have found that safety interventions - such as walkers, grab bars, ramps and other home modifications - allow many stroke survivors to keep living independently in their homes and may reduce their risk of death.

19 Jun 2024

Study shows effects of year-long heavy resistance training on vital leg strength

Twelve months of heavy resistance training - exercise that makes muscles work against a force - around retirement preserves vital leg strength years later, show the follow up results of a clinical trial, published online in the open access journal BMJ Open Sport & Exercise Medicine.

19 Jun 2024

Study: Anti-inflammatory drug celecoxib benefits PIK3CA-mutated colon cancer patients

An analysis of data from a randomized clinical trial for patients with stage 3 colon cancer found that those with PIK3CA mutations who took celecoxib, an anti-inflammatory drug, after surgery lived significantly longer and had longer disease-free survival compared to those without the mutation.

18 Jun 2024

GPT-4 enhances clinical trial screening accuracy and cuts costs

Researchers evaluated the RECTIFIER system, a RAG-enabled GPT-4, which showed high accuracy and efficiency in screening clinical trial participants for heart failure, outperforming traditional methods in certain aspects.

18 Jun 2024

Oral semaglutide proves effective for type 2 diabetes and weight loss in Dutch study

A recent study from the PIONEER REAL Netherlands trial demonstrated that oral semaglutide effectively manages type 2 diabetes and supports weight loss in adults.

18 Jun 2024

Nicotinamide riboside boosts walking endurance in peripheral artery disease

The over-the-counter supplement nicotinamide riboside, a form of vitamin B3, increased the walking endurance of patients with peripheral artery disease, a chronic leg condition for which there are few effective treatments.

18 Jun 2024

Older women are different than older men. Their health is woefully understudied.

Medical research has shortchanged women for decades. This is particularly true of older women, leaving physicians without critically important information about how to best manage their health.

18 Jun 2024

New research explores maternal influence on brain biomarkers

A new study by investigators from Mass General Brigham suggests that whether a person inherits risk of Alzheimer's disease from their mother or father influences risk of biological changes in the brain that lead to disease. By evaluating 4,400 cognitively unimpaired adults ages 65-85, the team found those with a history of Alzheimer's disease (AD) on either their mother's side or both parents' sides had increased amyloid in their brains. Their results are published in JAMA Neurology.

18 Jun 2024

New AI tool could revolutionize clinical trial efficiency and cost

Generative Artificial Intelligence (Gen AI) can rapidly and accurately screen patients for clinical trial eligibility, according to a new study from Mass General Brigham researchers. Such technology could make it faster and cheaper to evaluate new treatments and, ultimately, help bring successful ones to patients.

17 Jun 2024

Clinical Trial News and Research

Empowering older adults: Wearable tech made easier with personalized support

Insilico Medicine leadership team shares insights on AI-powered healthcare innovation

Anakinra shows promise in reducing symptoms in patients with Sanfilippo syndrome

Repurposing anti-retroviral medications for brain tumor treatment: The RETREAT trial

GLP-1 agonists linked to reduced dementia risk in type 2 diabetes patients

Combining JAK inhibitors with checkpoint inhibitors improves cancer immunotherapy response

Role of SMIM1 gene in obesity uncovered

JAK inhibitor ruxolitinib enhances immunotherapy in Hodgkin lymphoma patients

Walking reduces recurrence of low back pain, study finds

Non-chemotherapy treatment regimen achieves full remission in aggressive B-cell lymphoma

FDA approves a clinical trial to test the effectiveness of new brain sensor array

Improving stroke survivor health outcomes through home safety interventions

Study shows effects of year-long heavy resistance training on vital leg strength

Study: Anti-inflammatory drug celecoxib benefits PIK3CA-mutated colon cancer patients

GPT-4 enhances clinical trial screening accuracy and cuts costs

Oral semaglutide proves effective for type 2 diabetes and weight loss in Dutch study

Nicotinamide riboside boosts walking endurance in peripheral artery disease

Older women are different than older men. Their health is woefully understudied.

New research explores maternal influence on brain biomarkers

New AI tool could revolutionize clinical trial efficiency and cost

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