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JAK2 inhibitor ruxolitinib shows promise in treating CMML patients

Chronic myelomonocytic leukemia (CMML) is a rare type of myelodysplastic, myeloproliferative neoplasm characterized by increased numbers of peripheral monocytes and less than 20 percent blasts. CMML has few treatment options and patients only survive on average for 12 to 24 months.

29 May 2015

Researchers identify chemical pathway associated with seizures, shorter survival in patients with malignant glioma

Researchers at the University of Alabama at Birmingham have identified a chemical pathway that may be associated with seizures and shorter patient survival in some patients with malignant glioma, the most common and deadly form of brain tumor. In findings published May 27 in Science Translational Medicine, the researchers suggest that a transporter known as SXC is responsible for boosting levels of glutamate in the brains of some glioma patients.

28 May 2015

Removing accumulated mutant p53 protein regresses tumors, increases cancer survival

Removing accumulated mutant p53 protein from a cancer model showed that tumors regress significantly and survival increases. This finding, by an international team of cancer researchers led by Ute Moll, MD, Professor of Pathology at Stony Brook University School of Medicine, is reported in a paper published advanced online May 25 in Nature.

26 May 2015

nTMS analysis of motor areas improves prognosis of patients with malignant brain tumors

A method known as navigated transcranial magnetic stimulation (nTMS) has been gaining importance in neurosurgery for some time now.

22 May 2015

Nanoparticle-based therapy effective in treating mice with multiple myeloma

Researchers have designed a nanoparticle-based therapy that is effective in treating mice with multiple myeloma, a cancer of immune cells in the bone marrow.

21 May 2015

Researchers reveal molecular steps that allow pancreatic cancer to spread to the liver

An international team led by Weill Cornell Medical College investigators has illuminated the precise molecular steps that enable pancreatic cancer to spread to the liver -- the event that makes the most common form of the disease lethal. By understanding this process, investigators say their discovery can lead to targeted treatments that delay metastasis, and could offer clinicians a new biomarker to test for the earliest signs of pancreatic cancer.

19 May 2015

Studies support use of ThyraMIR and ThyGenX to improve detection of benign/malignant thyroid nodules

Data will be presented at both Digestive Disease Week (DDW) and the American Association of Clinical Endocrinologists (AACE) annual medical meetings.

18 May 2015

Researchers make major step toward finding target to combat drug-resistant neuroblastoma

Researchers at Children's Hospital Los Angeles have made an important step toward finding a target in the fight against drug-resistant neuroblastoma (NBL), the most common solid malignancy found, outside of the skull, in children.

14 May 2015

Loyola study examines survival outcomes in patients with mesenchymal chondrosarcoma

Among the deadliest cancers is a rare malignancy called mesenchymal chondrosarcoma, which begins in cartilage around bones and typically strikes young adults.

13 May 2015

Sheffield Hospitals shortlisted for record number of national Patient Safety awards

Sheffield Teaching Hospitals NHS Foundation Trust has been shortlisted for a record number of national Patient Safety Awards in recognition of outstanding practice in the field...

13 May 2015

Research paves way for development of individualized immunotherapy for treating cancer

Mainz-based researchers have made significant advances with regard to the development of individualized immunotherapy strategies for treating cancer. They have managed to identify the relevant genetic changes or mutations associated with various types of cancer and have determined their individual blueprints.

13 May 2015

Raising lupus awareness: an interview with Professor Ramsey-Goldman, MD

Lupus is a chronic, autoimmune disease, with many different symptoms so it is hard to diagnose. It affects each person differently and it has an unpredictable disease course with flare ups and quiet time. Some patients describe lupus as if they are riding a roller coaster with blinders on because they cannot always tell when they will feel well or sick...

11 May 2015

Quantitative phosphoproteomic approach to identify targeted cancer therapy

Winner of the Louise Eisenhardt Traveling Scholarship Award, Teresa Purzner, MD, presented her research, Quantitative Phosphoproteomics for Targeted Cancer Therapy.

7 May 2015

Cardiff scientists develop novel anti-cancer stem cell compound

Cardiff University scientists have developed a novel anti-cancer stem cell agent capable of targeting aggressive tumour forming cells common to breast, pancreas, colon and prostate cancers.

7 May 2015

Stanford University professor named recipient of 2015 ECOG-ACRIN Young Investigator Award

Heather Wakelee, MD, is the recipient of the 2015 ECOG-ACRIN Young Investigator Award, the ECOG-ACRIN Cancer Research Group announced today. Dr. Wakelee is associate professor of medicine in the Division of Oncology at the Stanford University School of Medicine in Stanford, Calif.

7 May 2015

Weston Park Hospital offers two cutting-edge treatments for rare cancer tumours, prostate cancer

TWO cutting-edge cancer treatments using targeted radioactive therapy injections to destroy cancer cells are now being offered to patients with rare neuroendocrine tumours and patients with prostate cancer at Weston Park Hospital.

6 May 2015

Study shows that periodontal treatment can reduce symptoms of prostatitis

Treating gum disease reduced symptoms of prostate inflammation, called prostatitis, report researchers from Case Western Reserve University School of Dental Medicine and the Departments of Urology and Pathology at University Hospitals Case Medical Center.

6 May 2015

Scientists grow miniature human myelomas in shell-less chicken eggs to study multiple myeloma

Multiple myeloma is an incurable cancer of the bone marrow. To date, no screening systems have been available to examine the effects of new drugs in a 3D environment. Researchers on the EU project OPTATIO might now fill this gap. They succeeded in growing miniature human myelomas in shell-less chicken eggs in order to screen new marine compounds for anti-myeloma activity.

5 May 2015

No evidence for cancer risk with growth hormone therapy

There is no evidence that growth hormone (GH) therapy increases the likelihood of neoplasms in children with no additional risk factors, says the Pediatric Endocrine Society Drug and Therapeutics Committee.

1 May 2015

Thyroid ultrasound ‘not highly accurate’ for malignancy in children

Ultrasound has only limited value for diagnosing thyroid cancer in children, say the authors of a meta-analysis.

1 May 2015

Malignant News and Research

JAK2 inhibitor ruxolitinib shows promise in treating CMML patients

Researchers identify chemical pathway associated with seizures, shorter survival in patients with malignant glioma

Removing accumulated mutant p53 protein regresses tumors, increases cancer survival

nTMS analysis of motor areas improves prognosis of patients with malignant brain tumors

Nanoparticle-based therapy effective in treating mice with multiple myeloma

Researchers reveal molecular steps that allow pancreatic cancer to spread to the liver

Studies support use of ThyraMIR and ThyGenX to improve detection of benign/malignant thyroid nodules

Researchers make major step toward finding target to combat drug-resistant neuroblastoma

Loyola study examines survival outcomes in patients with mesenchymal chondrosarcoma

Sheffield Hospitals shortlisted for record number of national Patient Safety awards

Research paves way for development of individualized immunotherapy for treating cancer

Raising lupus awareness: an interview with Professor Ramsey-Goldman, MD

Quantitative phosphoproteomic approach to identify targeted cancer therapy

Cardiff scientists develop novel anti-cancer stem cell compound

Stanford University professor named recipient of 2015 ECOG-ACRIN Young Investigator Award

Weston Park Hospital offers two cutting-edge treatments for rare cancer tumours, prostate cancer

Study shows that periodontal treatment can reduce symptoms of prostatitis

Scientists grow miniature human myelomas in shell-less chicken eggs to study multiple myeloma

No evidence for cancer risk with growth hormone therapy

Thyroid ultrasound ‘not highly accurate’ for malignancy in children

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