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Newborn mouse model yields clues to cause of devastating gut disease in anemic preemies

Physicians have long suspected that red blood cell transfusions given to premature infants with anemia may put them in danger of developing necrotizing enterocolitis, or NEC, a potentially lethal inflammatory disease of the intestines.

From Johns Hopkins Medicine 13 Aug 2019

Negative memory hippocampal engrams could underlie cognitive symptoms of depression

Physical manifestations of negative memories in the hippocampus could underlie cognitive symptoms of depression, according to research in mice published in JNeurosci. Inhibiting these manifestations could be a future treatment route.

From Society for Neuroscience 13 Aug 2019

Longer-lived, but less toxic drug may work better for pancreatic cancer

Unlike many other cancers, most pancreatic tumors are rock hard.

9 Aug 2019

Study shows how cigarette smoke drives tumor aggressiveness in head and neck cancer

Head and neck cancer is the sixth most common cancer in the world. The vast majority of cases are head and neck squamous cell carcinoma, a type of cancer that arises in the outer layer of the skin and mucous membranes of the mouth, nose and throat.

8 Aug 2019

New improved model for cancer wasting syndrome cachexia

A new model of cancer-related cachexia promises to help scientists understand why patients with cancer show severe wasting, which in turn may drive the development of better therapies.

7 Aug 2019

New mouse model could lead to a better understanding of cachexia syndrome

A study published in Cell Reports Aug. 6 describes the generation of a new mouse model developed at Hollings Cancer Center that could lead to a better understanding of the cachexia syndrome. This wasting condition, characterized by excessive weight loss, has one of the highest incidences in pancreatic cancer patients.

6 Aug 2019

New nanovaccine for deadly skin cancer

Tel Aviv scientists have published their version of a vaccine against the deadly skin cancer malignant melanoma, which arises from the pigment producing cells of the skin. This is the most feared form of skin cancer, with a high tendency to metastasize to distant parts of the body, including the brain.

6 Aug 2019

Whole body vibration helps reduce inflammation, thanks to the gut microbiome

Whole body vibration appears to improve many symptoms of type II diabetes mellitus, wherein glucose and destructive inflammation shoots up. The procedure helps the body use glucose as an energy source, and at the same time, modify the microbiome to fight inflammation, a new study says.

6 Aug 2019

Tel Aviv researchers develop a nano-vaccine for the most aggressive skin cancer

Researchers at Tel Aviv University have developed a novel nano-vaccine for melanoma, the most aggressive type of skin cancer.

5 Aug 2019

Whole body vibration adjusts the microbiome and immune cells to deter inflammation in diabetes

In the face of diabetes, a common condition in which glucose and levels of destructive inflammation soar, whole body vibration appears to improve how well our body uses glucose as an energy source and adjust our microbiome and immune cells to deter inflammation, investigators report.

5 Aug 2019

Discovery of distinct lung cancer pathways could help future patients

Known for its poor prognosis, lung adenocarcinoma is the most common type of lung cancer, responsible for about 4 of 10 diagnoses, according to the National Cancer Institute.

2 Aug 2019

Mice brain study reveals secrets about Alzheimer’s

Researchers from University of California, Irvine have found the key responses of brain cells to Alzheimer’s disease (AD) and say that this could help them understand the chronic debilitating and progressive neurodegenerative disease better in future.

1 Aug 2019

Harnessing anti-inflammatory function of macrophages holds great potential for treating diseases

Researchers at the University of Illinois at Chicago have identified a molecular switch that causes immune cells called macrophages to clean up cellular debris caused by infections instead of contributing to inflammation and tissue injury.

31 Jul 2019

Researchers unlock the key to clearly identifying diseased beta cells in type 2 diabetes

Researchers at Joslin Diabetes Center, an affiliate of Harvard Medical School, have unlocked the key to clearly identifying diseased beta cells in type 2 diabetes. This discovery has both research and therapeutic implications.

30 Jul 2019

'Digital twins' of individual patients may help find best medication to each patient

Advanced computer models of diseases can be used to improve diagnosis and treatment. The goal is to develop the models to "digital twins" of individual patients.

30 Jul 2019

Combination therapy could be a promising treatment for late-stage acute lymphoblastic leukemia

Acute lymphoblastic leukemia accounts for one in five adult leukemias, and is the most common pediatric cancer in the United States.

29 Jul 2019

Asthma drug can inhibit changes in early stages of diabetic retinopathy

In a study published July 26 online in the journal Diabetes, physician-researchers from University Hospitals Rainbow Babies and Children's Hospital and Case Western Reserve University School of Medicine found that the asthma medication montelukast (brand name Singulair) can inhibit early changes in diabetic retinopathy, the eye disease which develops due to diabetes, in a mouse model of type 1 diabetes.

29 Jul 2019

Scientists reverse social traits associated with autism in mouse model

Research has been ongoing in the field of genetic mutations and changes and brain and other neural disorders including Autism Spectrum Disorders (ASD) and a new study in mice models of autism has shown a possible link between mutations or deletions of the SHANK3 gene and a rare disorder called Phelan-McDermid syndrome and ASD.

29 Jul 2019

Scientists discover novel mechanism of action for NK cells in checkpoint inhibitor for cancer

PD-L1 checkpoint inhibitors are a powerful and growing form of immunotherapy used to treat melanoma, kidney cancer, head and neck cancers, Hodgkin's lymphoma and other cancers.

27 Jul 2019

Australian researchers discover gene that plays key role in aggressive childhood cancer

Neuroblastoma accounts for 15% of total childhood cancer deaths. The survival rate of high-risk neuroblastoma patients is 50%.

27 Jul 2019

Mouse Model News and Research

Newborn mouse model yields clues to cause of devastating gut disease in anemic preemies

Negative memory hippocampal engrams could underlie cognitive symptoms of depression

Longer-lived, but less toxic drug may work better for pancreatic cancer

Study shows how cigarette smoke drives tumor aggressiveness in head and neck cancer

New improved model for cancer wasting syndrome cachexia

New mouse model could lead to a better understanding of cachexia syndrome

New nanovaccine for deadly skin cancer

Whole body vibration helps reduce inflammation, thanks to the gut microbiome

Tel Aviv researchers develop a nano-vaccine for the most aggressive skin cancer

Whole body vibration adjusts the microbiome and immune cells to deter inflammation in diabetes

Discovery of distinct lung cancer pathways could help future patients

Mice brain study reveals secrets about Alzheimer’s

Harnessing anti-inflammatory function of macrophages holds great potential for treating diseases

Researchers unlock the key to clearly identifying diseased beta cells in type 2 diabetes

'Digital twins' of individual patients may help find best medication to each patient

Combination therapy could be a promising treatment for late-stage acute lymphoblastic leukemia

Asthma drug can inhibit changes in early stages of diabetic retinopathy

Scientists reverse social traits associated with autism in mouse model

Scientists discover novel mechanism of action for NK cells in checkpoint inhibitor for cancer

Australian researchers discover gene that plays key role in aggressive childhood cancer

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