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New NIH funding will accelerate progress in TB vaccine development

Seattle Children's Research Institute is one of three recipients of $30 million in first-year-funding provided by the National Institute of Allergy and Infectious Diseases, part of the National Institutes of Health, to establish centers for immunology research to accelerate progress in tuberculosis vaccine development.

15 Nov 2019

HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

Adolescents and young adults who were born to mothers with HIV but remained uninfected themselves still face a greatly heightened risk of obesity and asthma-like symptoms, researchers from Massachusetts General Hospital have found.

15 Nov 2019

Newly identified antibody has potential to stop, reverse pulmonary arterial hypertension

Scientists at the University of Sheffield, working in collaboration with drug and vaccine developer Kymab Ltd, Cambridge, have identified a novel antibody that has the potential to become a new treatment for pulmonary arterial hypertension (PAH).

15 Nov 2019

Study uncovers how the molecule-sorting station in our cells is formed and maintained

The cells in our body are workshops that continuously operate to produce and process substances to keep us going. When a substance enters a cell for processing, it is surrounded by a portion of the cell's outer membrane to form a sac.

15 Nov 2019

New way to promote insulin production in pre-diabetes phase discovered

Nanyang Technological University, Singapore scientists have discovered that a type of immune cell known as 'pancreatic islet macrophages' is capable of promoting insulin production during the pre-diabetes phase.

15 Nov 2019

UCI researchers develop new cell therapy to improve memory, prevent seizures after TBI

Researchers from the University of California, Irvine developed a breakthrough cell therapy to improve memory and prevent seizures in mice following traumatic brain injury.

15 Nov 2019

Mining 'darkest' parts of the genome in cancer cells yields gold

Mining the rich uncharted territory of the genome or genetic material of a cancer cell has yielded gold for Princess Margaret scientists: new protein targets for drug development against prostate cancer.

15 Nov 2019

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

In a surprising finding using the standard animal model of Down syndrome (DS), scientists were able to correct the learning and memory deficits associated with the condition -- the leading genetic cause of cognitive disability and the most frequently diagnosed chromosomal disorder in the U.S. -- with drugs that target the body's response to cellular stresses.

15 Nov 2019

Lab Innovations 2019 achieves record breaking numbers

Lab Innovations celebrated its 8th edition on 30 & 31 October 2019, trumping all records for the event. Attracting 3,860 attendees - an impressive 24% increase on the previous year - this makes it the largest Lab Innovations to date.

From Lab Innovations 15 Nov 2019

Study unravels how insulin interacts with its receptor

Since the discovery of insulin nearly 100 years ago, scientists have explored how it interacts with its receptor with the goal of improving the ability of therapeutic insulins to mimic the way insulin works in the body.

14 Nov 2019

Gut microbes may alter the aging process, study finds

An international research team led by Nanyang Technological University, Singapore (NTU Singapore) has found that microorganisms living in the gut may alter the aging process, which could lead to the development of food-based treatment to slow it down.

14 Nov 2019

Research shows how bacteria associated with Crohn's disease tolerate antibiotics

Bacteria associated with Crohn's disease rely on multiple stress responses to survive, multiply, and tolerate antibiotics within white blood cells called macrophages, according to a study published November 14 in the open-access journal PLOS Pathogens by Olivier Espéli of the College de France and PSL Research University in Paris, France, and colleagues.

14 Nov 2019

Non-coding enhancer DNA may be key for identifying genetic risk in neurological conditions

One might think that the primary cause of most genetically linked diseases comes from mutations in coding DNA -- alterations in coding regions of the genome that can lead directly to changes in the expression of particular proteins important for a healthy body.

14 Nov 2019

Research explains why immunotherapy fails against prostate cancer bone metastases

Prostate cancer that spreads to the bone triggers the destruction of bone tissue that, in turn, thwarts the effectiveness of immune checkpoint inhibitors by blocking the development of T cells that are crucial to successful treatment, researchers from The University of Texas MD Anderson Cancer Center report in Cell.

14 Nov 2019

Altering malarial parasite genes to prevent malaria

Malaria is a mosquito-borne disease caused by the parasitic organism called Plasmodium, of which there are several types that cause the different kinds of malarial fever. This age-old infection still kills over 400,000 people every year, all over the world. A new study published in the journal Cell on November 14, 2019, shows how a simple tweaking of the genes of this organism could quite conceivably lead to the elimination of this disease altogether.

14 Nov 2019

Lithium corrects radiation damage to brain in young cancer patients

A new study on mice, published online in the journal Molecular Psychiatry, on November 14, 2019, shows that the intermittent use of lithium, which is widely used to stabilize the mood in conditions such as bipolar disorder, can correct memory and learning losses due to radiation therapy to the brain in very young animals, even when the lithium is given long after the injury.

14 Nov 2019

Study sheds light on how Zika virus causes microcephaly in newborns

A new study led by researchers at Baylor College of Medicine revealed how in utero Zika virus infection can lead to microcephaly in newborns. The team discovered that the Zika virus protein NS4A disrupts brain growth by hijacking a pathway that regulates the generation of new neurons.

14 Nov 2019

B Cell News and Research

New NIH funding will accelerate progress in TB vaccine development

HIV-exposed but uninfected individuals at risk of obesity and asthma-like symptoms

Newly identified antibody has potential to stop, reverse pulmonary arterial hypertension

Study uncovers how the molecule-sorting station in our cells is formed and maintained

New way to promote insulin production in pre-diabetes phase discovered

UCI researchers develop new cell therapy to improve memory, prevent seizures after TBI

Mining 'darkest' parts of the genome in cancer cells yields gold

Scientists reverse learning and memory deficits with drugs in animal model of Down syndrome

Lab Innovations 2019 achieves record breaking numbers

Study unravels how insulin interacts with its receptor

Gut microbes may alter the aging process, study finds

Research shows how bacteria associated with Crohn's disease tolerate antibiotics

Non-coding enhancer DNA may be key for identifying genetic risk in neurological conditions

Research explains why immunotherapy fails against prostate cancer bone metastases

Altering malarial parasite genes to prevent malaria

Lithium corrects radiation damage to brain in young cancer patients

Study sheds light on how Zika virus causes microcephaly in newborns

Inhaled nanoparticles can help treat lung cancer

Understanding how pressure is regulated in the eye could lead to new treatments for glaucoma

Dopamine D2 receptor modulates Wnt expression, controls cell proliferation

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