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NIH-funded investigators develop therapeutic compound effective against malaria

An international team that includes NIH-funded researchers at Stanford University has developed a therapeutic compound that is effective in inhibiting Plasmodium falciparum, one of five species of parasite that infects people with malaria, and the strain which causes the highest number of malaria deaths.

13 Mar 2016

FDA approves Xalkori (crizotinib) to treat patients with ROS-1 positive NSCLC

The U.S. Food and Drug Administration today approved Xalkori (crizotinib) to treat people with advanced (metastatic) non-small cell lung cancer (NSCLC) whose tumors have an ROS-1 gene alteration. Xalkori is the first and only FDA approved treatment for patients with ROS-1 positive NSCLC.

13 Mar 2016

Lots of 'good' cholesterol may be bad

Recent research has identified a genetic mutation that prevents high-density-lipoprotein (HDL) cholesterol from being taken up by cells.

11 Mar 2016

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

microRNAs (miRs) are small endogenous noncoding RNA molecules (20–23 nucleotides) derived from imperfectly paired hairpin RNA structures naturally encoded in the genome that act specifically as triggering molecules to control translational repression or mRNA degradation.

11 Mar 2016

Negative cancer clinical trials have long-term impact on research

Cancer clinical trials with negative results don't make an immediate splash in the scientific literature, but they do have a long-term impact on cancer research, according to a new study by SWOG, the federally funded international clinical trials network.

11 Mar 2016

New drug combination treatment makes breast cancer tumours disappear in just 11 days

Approximately a quarter of women with HER2 positive breast cancer, who were treated with a combination of the targeted drugs lapatinib and trastuzumab before surgery and chemotherapy, saw their tumours shrink significantly or even disappear, according to results from a clinical trial.

11 Mar 2016

Breast cancer can be more aggressive in obese people

An international team of researchers, with the participation of the University of Granada, has revealed new data on why breast cancer has a higher incidence and is more aggressive in obese people. The reason is that peritumoral fat (the fat around the tumor) facilitates the expansion and invasion of cancer stem cells (CSCs), which are responsible of the onset and growth of the tumor.

11 Mar 2016

Mucus may hold key to better cancer treatment

What do cancer cells and a runny nose have in common? The answer is mucus; and researchers at the Stephenson Cancer Center at the University of Oklahoma have shown it may hold the key to making cancer treatment better.

11 Mar 2016

Wake Forest Baptist offers DigniCap scalp cooling system to breast cancer patients undergoing chemotherapy

Wake Forest Baptist Medical Center is the first medical center in the United States to offer the FDA-cleared DigniCap scalp cooling system to patients undergoing chemotherapy for breast cancer.

11 Mar 2016

Patients with early-stage NSCLC and low SMARCA4 expression may benefit from platinum-based chemotherapy

The activity level of a particular gene in lung tumors might identify lung-cancer patients who will likely be helped by a particular chemotherapy regimen given to prevent recurrence after surgery.

11 Mar 2016

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Malfunctioning mitochondria — the power plants in cells — are behind the damage caused by strokes, heart attacks, and neurodegenerative diseases, but little has been known about how to stop these reactors from melting down, destroying cells and tissue. Mitochondria also take up calcium, which regulates energy production.

11 Mar 2016

Phase 3 study: Sarilumab monotherapy meets primary endpoint in active rheumatoid arthritis patients

Regeneron Pharmaceuticals, Inc. and Sanofi today announced that a Phase 3 monotherapy study met its primary endpoint demonstrating that sarilumab was superior to adalimumab (marketed by AbbVie as HUMIRA) in improving signs and symptoms in patients with active rheumatoid arthritis (RA) at Week 24.

11 Mar 2016

Researchers reveal how butterfly disease patients develop cutaneous squamous cell carcinomas

Fragile skin that blisters easily: 90 percent of the patients that suffer from the skin condition recessive dystrophic epidermolysis bullosa (RDEB) develop rapidly progressing cutaneous squamous cell carcinomas, a type of skin cancer, by the age of 55. 80 percent of these patients will die due to metastasis within five years after the cancer has been first detected.

11 Mar 2016

STING agonists developed to induce cellular death in B cell malignancies

In almost every mammalian cell, you will find the endoplasmic reticulum, a network of continuous membranes responsible for controlling metabolism as well as the folding, assembly and secretion of proteins.

11 Mar 2016

Researchers develop new process for synthesis of potent anti-cancer agents

A team led by Rice University synthetic organic chemist K.C. Nicolaou has developed a new process for the synthesis of a series of potent anti-cancer agents originally found in bacteria.

10 Mar 2016

CYP3A7 gene may over-activate metabolism, reduce effectiveness of cancer treatments

Some patients with breast cancer, lung cancer and leukaemia seem to fare poorly after treatment because of the effects of a particular gene, a new study finds.

10 Mar 2016

New procedure allows kidney transplants from incompatible donors

Researchers have found a way to stop patients rejecting kidneys that have come from incompatible donors, potentially slashing the waiting time for thousands of people in desperate need of the procedure.

10 Mar 2016

Popular kidney cancer drugs do not reduce incidence of recurrence

Two widely used targeted therapy drugs approved by the FDA for the treatment of metastatic kidney cancer—sorafenib and sunitinib—are no more effective than a placebo in preventing return of the disease to increase life spans of patients suffering from advanced kidney cancer after surgery, according to a new multi-institutional study in the Lancet led by a researcher at the Abramson Cancer Center (ACC) of the University of Pennsylvania.

10 Mar 2016

Scientists discover molecular switch that can burn off excess pounds

The number of overweight people is increasing worldwide -- and thus the risk of developing diabetes or cardiovascular disease.

10 Mar 2016

Secretory capacity of human gut does not decline with age, shows study

A breakthrough in basic research and the first comprehensive study on the secretory activity of the human intestine: over a period of eight years, Dr. Dagmar Krüger of the Department of Human Biology at TU Munich has examined more than 2200 specimens from around 450 patients with bowel disease.

10 Mar 2016

Drugs News and Research

NIH-funded investigators develop therapeutic compound effective against malaria

FDA approves Xalkori (crizotinib) to treat patients with ROS-1 positive NSCLC

Lots of 'good' cholesterol may be bad

Delivering microRNAs in cancer treatment: an interview with Dr Conde and Prof Artzi

Negative cancer clinical trials have long-term impact on research

New drug combination treatment makes breast cancer tumours disappear in just 11 days

Breast cancer can be more aggressive in obese people

Mucus may hold key to better cancer treatment

Wake Forest Baptist offers DigniCap scalp cooling system to breast cancer patients undergoing chemotherapy

Patients with early-stage NSCLC and low SMARCA4 expression may benefit from platinum-based chemotherapy

Findings offer novel way for creating drugs to stop mitochondria from destroying cells during stress

Phase 3 study: Sarilumab monotherapy meets primary endpoint in active rheumatoid arthritis patients

Researchers reveal how butterfly disease patients develop cutaneous squamous cell carcinomas

STING agonists developed to induce cellular death in B cell malignancies

Researchers develop new process for synthesis of potent anti-cancer agents

CYP3A7 gene may over-activate metabolism, reduce effectiveness of cancer treatments

New procedure allows kidney transplants from incompatible donors

Popular kidney cancer drugs do not reduce incidence of recurrence

Scientists discover molecular switch that can burn off excess pounds

Secretory capacity of human gut does not decline with age, shows study

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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