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MDI Biological Laboratory discover mechanisms underlying regeneration of heart tissue

The MDI Biological Laboratory has announced new discoveries about the mechanisms underlying the regeneration of heart tissue by Assistant Professor Voot P. Yin, Ph.D., which raise hope that drugs can be identified to help the body grow muscle cells and remove scar tissue, important steps in the regeneration of heart tissue.

10 Mar 2016

Bullied young children not at higher risk of substance abuse later in life

Being bullied can hurt young children in many ways, but a new UT Dallas study found that it does not lead to later substance abuse.The research by three criminologists in UT Dallas' School of Economic, Political and Policy Sciences discovered that students who were bullied in third grade did not have a greater risk of using drugs or alcohol by ninth grade.

10 Mar 2016

Small, sensitive biosensors could help personalize treatment for Alzheimer's disease

A portable biosensor that could show how disease is progressing in patients with Alzheimer's could greatly improve people's quality of life in the future, according to a new review published in Biosensors and Bioelectronics.

10 Mar 2016

CWRU researcher to customize tobacco mosaic virus to treat human cancers

A Case Western Reserve University researcher has been awarded more than $3 million in federal and foundation grants to turn common plant viruses into cancer sleuths and search-and-destroy emissaries.

10 Mar 2016

Dihydroartemisinin-piperaquine effective in treating malaria in pregnant women

Pregnant women can be protected from malaria, a major cause of prematurity, low birth weight and death in infants in Africa, with dihydroartemisinin-piperaquine , an artemisinin combination therapy that is already widely used to treat malaria in adults, according to a study by researchers at UC San Francisco and in Uganda.

10 Mar 2016

Early childhood intervention guide can help prevent substance use disorders

An online guide about interventions in early childhood that can help prevent drug use and other unhealthy behaviors was launched today by the National Institute on Drug Abuse, part of the National Institutes of Health.

10 Mar 2016

Vanderbilt investigators isolate human antibodies against H7 bird flu

Researchers at Vanderbilt University Medical Center have isolated human antibodies against a type of bird flu that has killed more than 200 people in China since 2012 and which may pose a worldwide pandemic threat.

10 Mar 2016

New vaccine delays effects of nicotine within first 10 minutes after injection

Many people who smoke want to quit, but the urge to light up is often irresistible. An effective vaccine to help people kick the habit once and for all has been elusive. But now, scientists report in ACS' Journal of Medicinal Chemistry a new vaccine design that could help achieve this goal.

10 Mar 2016

Research could pave way for new generation of anti-cancer drugs

New research has identified a first step in the design of a new generation of anti-cancer drugs that include an agent to inhibit resistance to their effectiveness.

9 Mar 2016

Scientists discover brain mechanisms that separate food consumption from cravings

Researchers investigating eating disorders often study chemical and neurological functions in the brain to discover clues to overeating. Understanding non-homeostatic eating -- or eating that is driven more by palatability, habit and food cues -- and how it works in the brain may help neuroscientists determine how to control cravings, maintain healthier weights and promote healthier lifestyles. Scientists at the University of Missouri recently discovered the chemical circuits and mechanisms in the brain that separate food consumption from cravings. Knowing more about these mechanisms could help researchers develop drugs that reduce overeating.

9 Mar 2016

New software takes ensemble approach to determine presence of chemical structure in drug molecule

A computer program that can predict whether or not a given pharmaceutical will have worrying side effects has been developed by researchers in the USA. Md Jamiul Jahid and Jianhua Ruan of the Department of Computer Science, at the University of Texas at San Antonio, have developed the "in silico" testing system for drugs in the early stage of drug development.

9 Mar 2016

Novel nanoparticle technology can decipher protein structures and help access drug targets

Researchers at Karolinska Institutet, Sweden, have developed a nanoparticle technology that can be used to stabilise membrane proteins so that their structure can be studied in a lipid environment. The method, described in Nature Methods, makes it possible to access drug targets that previously could not be investigated and therefore potentially allows for the development of novel drugs, therapeutic antibodies and vaccines.

9 Mar 2016

Clinical review examines benefit of RT in breast cancer patients with BRCA1, BRCA2 mutations

In light of conflicting and inconclusive clinical data on the benefit of radiation therapy in cancer patients with the BRCA1 and BRCA2 mutation, a clinical review examined the current status of data regarding BRCA1 and BRCA2 deficiency and radiation therapy sensitivity and a potential strategy to intensify the effects of radiation therapy (RT) by poly(ADP-ribose) polymerase inhibitors (PARPi), the pharmacologic drugs under investigation as monotherapy for the treatment of breast cancer in patients with BRCA1 and BRCA2 mutations.

9 Mar 2016

Alcohol worst of all drugs that affect fetal health

The Centers for Disease Control and Prevention set off a firestorm of controversy this month when they suggested that women stop drinking alcohol if they are trying to get pregnant, or could get pregnant. Some people took this advice as the CDC prioritizing hypothetical, yet-to-be-conceived children over real women, which has brought up a number of issues from female autonomy to access to birth control—but how clear is the science about what causes fetal alcohol syndrome and related fetal alcohol spectrum disorders.

9 Mar 2016

Thermo Fisher exhibits new UHPLC-MS workflow solutions for biopharmaceutical characterization at Pittcon 2016

Biopharmaceutical companies can now achieve advanced levels of specificity, sensitivity and speed with specialized analytical workflow solutions for the characterization and quantification of proteins.

From Thermo Fisher Scientific Inc. 9 Mar 2016

Study: 2.3 million people living with HIV co-infected with HCV

An estimated 2.3 million people living with HIV are co-infected with hepatitis C virus (HCV) globally, a new study by the University of Bristol and the London School of Hygiene & Tropical Medicine has found.

9 Mar 2016

Metabolic syndrome treatment benefits MS patients

Oral antidiabetic medications have beneficial anti-inflammatory effects in patients with multiple sclerosis and metabolic syndrome, providing support for a link between metabolism and autoimmunity, researchers report.

9 Mar 2016

Antidepressants may play role in dental implant failure

Antidepressants, commonly used to treat anxiety, pain and other disorders, may play a role in dental implant failure, according to a new pilot study by University at Buffalo researchers.

8 Mar 2016

New possibilities in malaria drug development

Bringing three powerful chemical groups together offers new possibilities in drug development.A new chemical route for potential antimalarial compounds has been pioneered by chemists at KAUST. It offers hope for improved treatment of malaria, a disease that kills more than a million people each year

8 Mar 2016

Drug-incorporated nanoparticle platforms allow for selective targeting of cancer cells

Cancer is a group of diseases characterized by the uncontrolled growth and spread of abnormal cells. It is a leading cause of death and the burden is expected to grow worldwide due to the growth and aging of the population, mainly in less developed countries, in which about 82% of the world's population resides. By 2030, the global burden is expected to grow to 21.7 million new cancer cases and 13 million cancer deaths simply due to the growth and aging of the population. Current cancer therapy approaches are based in surgery, radiotherapy and chemotherapy, being the chemotherapy the one that shows the greater efficiency for cancer treatment, mainly in more advanced stages. A major problem with this conventional chemotherapy is its toxicity and it also destroys healthy tissues resulting in systemic toxicity besides beneficial characteristics of killing cancer cells. Anticancer drugs also destroy healthy tissues resulting in systemic toxicity.

8 Mar 2016

Drugs News and Research

MDI Biological Laboratory discover mechanisms underlying regeneration of heart tissue

Bullied young children not at higher risk of substance abuse later in life

Small, sensitive biosensors could help personalize treatment for Alzheimer's disease

CWRU researcher to customize tobacco mosaic virus to treat human cancers

Dihydroartemisinin-piperaquine effective in treating malaria in pregnant women

Early childhood intervention guide can help prevent substance use disorders

Vanderbilt investigators isolate human antibodies against H7 bird flu

New vaccine delays effects of nicotine within first 10 minutes after injection

Research could pave way for new generation of anti-cancer drugs

Scientists discover brain mechanisms that separate food consumption from cravings

New software takes ensemble approach to determine presence of chemical structure in drug molecule

Novel nanoparticle technology can decipher protein structures and help access drug targets

Clinical review examines benefit of RT in breast cancer patients with BRCA1, BRCA2 mutations

Alcohol worst of all drugs that affect fetal health

Thermo Fisher exhibits new UHPLC-MS workflow solutions for biopharmaceutical characterization at Pittcon 2016

Study: 2.3 million people living with HIV co-infected with HCV

Metabolic syndrome treatment benefits MS patients

Antidepressants may play role in dental implant failure

New possibilities in malaria drug development

Drug-incorporated nanoparticle platforms allow for selective targeting of cancer cells

Bringing real-time analytics to downstream bioprocess monitoring

Designing fluidic architecture for scalable diagnostic platforms

Evaluating new approaches for rare disease genomics

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