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Ageing slows brain protein clearance and shifts synaptic waste to microglia

Ageing slows neuronal protein degradation in mice, leading to widespread accumulation and aggregation of long-lived proteins, particularly at synapses. As neuronal clearance declines, microglia selectively accumulate synaptic proteins, suggesting a compensatory but potentially strained proteostasis pathway in the ageing brain.

22 Jan 2026

Trojan horse immunotherapy opens tumors to immune system attack

Scientists at the Icahn School of Medicine at Mount Sinai have developed an experimental immunotherapy that takes an unconventional approach to metastatic cancer: instead of going after cancer cells directly, it targets the cells that protect them.

22 Jan 2026

New partnership aims to expand global access to sickle cell gene therapy

Caring Cross, a 501(c)(3) non-profit dedicated to improving access to advanced therapies, and Boston Children's Hospital today announced a collaboration to provide a sustainable, affordable pathway for patients to access stem cell gene therapies for the treatment of Sickle Cell Disease (SCD).

22 Jan 2026

Cancer vaccines enter a new era of personalized immunotherapy

A new comprehensive review from researchers at the Icahn School of Medicine at Mount Sinai details how decades of cancer vaccine research are converging into a new era of more precise, personalized, and effective immunotherapies, particularly when combined with other cancer treatments.

22 Jan 2026

Study explores how shared cells influence health across generations

During pregnancy, maternal and fetal cells migrate back and forth across the placenta, with fetal cells entering the mother's bloodstream and tissues.

22 Jan 2026

Targeted uterine mRNA treatment boosts fertility outcomes in mice

Researchers from the Wilmer Eye Institute, Johns Hopkins Medicine Center for Nanomedicine - which designs nanotechnology-based platforms for clinical translation across specialties - developed a strategy for delivering therapeutic messenger RNA (mRNA) to the inner lining of the uterus (endometrium) in mice via modified lipid nanoparticles (LNPs), which are small capsules made of fatty molecules.

22 Jan 2026

Brain cell precursors show constant myelin-making drive

In experiments with mice, Johns Hopkins Medicine scientists report new evidence that precursors of myelin-producing cells - one of the few brain cell types that continue to be produced in the adult brain - undergo differentiation widely and at a constant pace, rather than "as needed" in response to injury or advancing age.

22 Jan 2026

Moffitt researchers develop a new way to predict how cancer cells evolve

Researchers at Moffitt Cancer Center have developed a new way to predict how cancer cells evolve by gaining and losing whole chromosomes, changes that help tumors grow, adapt and resist treatment.

22 Jan 2026

Discovery explains why people with IBD have higher risk of colorectal cancer

A chain of immune reactions in the gut—driven by a key signaling protein and a surge of white blood cells from the bone marrow—may help explain why people with inflammatory bowel disease (IBD) have a higher risk of colorectal cancer, according to a preclinical study by Weill Cornell Medicine investigators.

22 Jan 2026

Facial wound secrets revealed for scarless repair

Tweaking a pattern of wound healing established millions of years ago may enable scar-free injury repair after surgery or trauma, Stanford Medicine researchers have found.

22 Jan 2026

Alterations in liver metabolism experienced by individuals with Down syndrome

Researchers at the University of Colorado Anschutz Linda Crnic Institute for Down Syndrome (Crnic Institute) have uncovered compelling evidence that individuals with Down syndrome experience significant alterations in liver metabolism, including elevated levels of bile acids in the bloodstream and other biomarkers of liver dysfunction.

22 Jan 2026

Methionine: A dietary key to surviving infection

As soon as you are wounded-whether from grabbing a hot pan or contracting the flu-you begin a unique journey through variable symptoms toward either recovery or death.

22 Jan 2026

Age-related changes in the gut microbiota impair intestinal stem cell function

A new study led by Hartmut Geiger at the University of Ulm, Germany, and Yi Zheng and Kodandaramireddy Nalapareddy, Cincinnati Children's Hospital Medical Center (CCHMC), USA reveals that age-related changes in the gut microbiota directly impair intestinal stem cell (ISC) function and that restoring a youthful microbial environment can reverse this decline.

22 Jan 2026

Researchers decipher a key mechanism that controls pancreatic cancer growth

Could this mark a shift in how we think about cancer therapy? At least in the laboratory, evidence suggests it may be.

22 Jan 2026

New ISSCR guidance charts path for pluripotent stem cell therapies

The International Society for Stem Cell Research (ISSCR) today announced the upcoming release of "Charting the Translational Pathway: ISSCR Best Practices for the Development of Pluripotent Stem Cell (PSC)-Derived Therapies," a new paper highlighting some of the most critical aspects of the ISSCR's breakthrough interactive resource designed to transform how PSC-derived therapies are developed, evaluated, and advanced toward clinical and commercial success.

22 Jan 2026

Researchers propose a new framework for understanding neutrophils

Researchers from Universidad Carlos III de Madrid (UC3M), the National Center for Cardiovascular Research (CNIC), and Yale University (USA) have published a comprehensive review article in the journal Cell that proposes a new framework for understanding neutrophils, the most abundant cells of the immune system.

22 Jan 2026

Unfolding the role of Hsp70 chaperones in neurodegeneration

Neurodegenerative diseases such as Alzheimer's, Parkinson's, Huntington's, and amyotrophic lateral sclerosis (ALS) affect millions of people worldwide, yet treatments remain largely limited to symptom management.

22 Jan 2026

Super-enhancers: Cancer's double-edged sword of growth and DNA damage

New study shows that cancer damages its own DNA by pushing key genes to work too hard. Researchers found that the most powerful genetic "on switches" in cancer cells, called super-enhancers, drive unusually intense gene activity.

22 Jan 2026

Study identifies a powerful strategy to overcome drug resistance in breast cancer

A new preclinical study from researchers at The University of Texas MD Anderson Cancer Center, published today in Nature Communications, identifies a powerful strategy to overcome drug resistance in breast cancer by simultaneously targeting two key cell-cycle regulators, CDK2 and CDK4/6.

22 Jan 2026